Methyltrifluoropyruvate

Figueroa, Ruth; Hsung, Richard P.; Li, Gang; Yang, Jin

doi:10.1002/047084289x.rn00769

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2019

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“…Some of them are well known and were considered in several reviews or book chapters. These examples include ethyl 4,4,4-trifluoroacetoacetate [16], methyl 3,3,3-trifluoropyruvate and its imines [17], ,unsaturated trifluoromethylketones [18,19] [24], 1-polyfluoroalkyl-2-iodoalkanes and 3-fluoro-3-polyfluoroalkyl acrylates [12].…”

Section: Introductionmentioning

confidence: 99%

New Approaches to the Synthesis of CF2X-substituted Heterocyclic Antitumor Cytostatic Agents

Чкаников¹,

Golubev²,

Belyaeva³

2019

INEOS OPEN

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This review summarizes recent investigations on the synthesis of fluorine-containing heterocyclic cytostatic agents starting from highly electrophilic unsaturated compounds: CF3or CF2X-containing cyanoethylenes, nitroalkenes, and acetoacetic esters. The possibility of introduction of diethoxyphosphoryl groups along with the fluorine-containing substituents into heterocycles is studied extensively. The examples of directed syntheses of fluorine-containing analogs of natural heterocyclic cytostatic agents are considered. The cytotoxic activities of the resulting compounds against several human cancer cell lines are discussed.

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