Metoprolol induces oxidative damage in common carp (Cyprinus carpio)

Martínez-Rodríguez, Héctor; Donkor, Kingsley K.; Brewer, Sharon; Galár-Martínez, Marcela; SanJuan-Reyes, Nely; Islas-Flores, Hariz; Sánchez-Aceves, Livier Mireya; Elizalde-Velázquez, Armando; Gómez-Oliván, Leobardo Manuel

doi:10.1016/j.aquatox.2018.02.012

Cited by 15 publications

(11 citation statements)

References 48 publications

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“…A wide diversity of aquatic species (n=80 taxa) were affected by exposure to PPCPs, consistent with Daughton and Ternes (1999) and Boxall (2004), even at low concentrations, as noted by De Lange et al ( 2006), Kohidai (2012), andMartinez-Rodriguez et al (2018). These effects include behavioural alterations, histological changes, biochemical responses, genotoxicity, and/or cytotoxicity (Boxall et al 2012).…”

Section: Summary Assessment Of Sublethal Effects Of Ppcps On Aquatic supporting

confidence: 77%

“…These PPCPs cause a significant increase in activity of antioxidant enzymes, including catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (Gred), and superoxidase dismutase (SOD) in tissues of gill, intestine, liver, and muscle in aquatic organisms (Kim et al 2009;Li et al 2009;Zhang et al 2012;Liu et al 2013;Liu et al 2014;Lin et al 2014;Huang et al 2016;Rodrigues et al 2016;Almeida et al 2017;Kuzikova et al 2017;Magini et al 2017;Morales et al 2018;Pan et al 2018;Wang et al 2018;Liu et al 2019;Parenti et al 2019;Wang et al 2019). These PPCPs also cause a significant increase in lipid peroxidation, elevation of hydroperoxide content (HPC), and significant inhibition in activity of acetylcholinesterase (AChE) in tissues of different organs (Li 2008;Oliveira et al 2009;Rhee et al 2013;Liu et al 2014;Li et al 2016a;Chen et al 2017;Liu et al 2017;Aguirre-Martinez et al 2018;Martinez-Rodriguez et al 2018;Sahu et al 2018;Liu et al 2019).…”

Section: Summary Assessment Of Sublethal Effects Of Ppcps On Aquatic mentioning

confidence: 99%

“…24 h Significant elevation of HPC in brain after exposure to 10 and 10000 μg/L. Significant elevation of HPC in gills after exposure to 0.01 and 10 μg/L (Martinez-Rodriguez et al 2018) Cyprinus carpio 48 h Significant elevation of HPC in brain after exposure to 0.01, 10 and 10000 μg/L (Martinez-Rodriguez et al 2018).72 h Significant elevation of HPC in brain after exposure to 10 mg/L(Martinez-Rodriguez et al 2018).96 hSignificant elevation of HPC in brain after exposure to 0.01 and 10 μg/L(Martinez-Rodriguez et al 2018).…”

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confidence: 99%

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Pharmaceuticals and personal care products and their sublethal and lethal effects in aquatic organisms

2021

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Pharmaceutical and personal care products (PPCPs) include over-the-counter and prescription drugs, veterinary drugs, fragrances, and cosmetics. PPCPs have been detected in aquatic environments at low concentrations and are emerging as contaminants of concern. PPCPs are primarily released into aquatic environments via untreated sewage, wastewater treatment plants, landfill leachate and can affect aquatic life through persistence, bioaccumulation, and toxicity. However, there are limited reviews of lethal and sublethal effects of PPCP exposures on aquatic organisms. To understand PPCP toxicity on aquatic organisms, a literature review was conducted which identified aquatic organisms known to be affected by PPCPs; concentrations of PPCPs reported as producing sublethal and lethal effects in aquatic organisms; and research gaps on PPCP aquatic toxicity. Twelve PPCPs were selected from three seminal studies for review, including bisphenol A, carbamazepine, erythromycin, fluoxetine, linear alkylbenzene sulfonate, metoprolol, naproxen, nonylphenol, ofloxacin, sertraline, sulfamethoxazole, and triclosan. Many aquatic species were affected by PPCPs at sublethal and lethal exposures, including sublethal effects at environmentally relevant concentrations. Because lethal effects were seldom observed at environmentally relevant concentrations, many studies considered PPCPs non-toxic. Few studies have compared effects of PPCPs on the same organisms for identical exposure parameters (time and concentration), resulting in wide variation in reported toxicity levels with limited consensus in the academic literature. Consensus in lethal concentrations was reported for Daphnia magna with 48 h exposure for bisphenol A and triclosan and Vibrio fischeri with 15 min exposure to carbamazepine. Environmentally relevant sublethal concentrations were higher than water quality guidelines developed for Canada and predicted no-effect concentrations derived globally. Species sensitivity distributions for some PPCPs show that aquatic species are affected lethally at environmentally relevant concentrations. More studies on indirect, and long-term ecological effects along with testing chronic toxicity of PPCPs at environmentally relevant concentrations, is recommended. These will help guide future research to determine extent and magnitude of PPCP concentrations in aquatic environments and help inform management decisions to reduce sources of PPCPs into the environment. Future management requires effective monitoring strategies regarding use, disposal, occurrence, and impacts at different life cycle stages of PPCPs in the environment.

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Section: Summary Assessment Of Sublethal Effects Of Ppcps On Aquatic supporting

confidence: 77%

Section: Summary Assessment Of Sublethal Effects Of Ppcps On Aquatic mentioning

confidence: 99%

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confidence: 99%

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Pharmaceuticals and personal care products and their sublethal and lethal effects in aquatic organisms

2021

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“…15,16 Recently, metoprolol has been demonstrated to induce oxidative stress in the liver and gills of common carp at 10 ng/L and histological alterations in rainbow trout at 1 μg/L, suggesting that the adverse effects occurred at environmentally relevant concentrations. 17,18 However, the occurrences and hazards of other types and newer generations of cardiovascular and lipid-lowering drugs and their metabolites are rarely explored.…”

Section: ■ Introductionmentioning

confidence: 99%

“…However, different from other pharmaceuticals such as antibiotics and steroid hormones, which were extensively studied, most of the present studies concerning cardiovascular drugs only focus on several β-blockers such as metoprolol and propranolol. For instance, the mean concentrations of metoprolol were reported ranged from 5 to 738 ng/L in European countries, including Germany and Spain. , Recently, metoprolol has been demonstrated to induce oxidative stress in the liver and gills of common carp at 10 ng/L and histological alterations in rainbow trout at 1 μg/L, suggesting that the adverse effects occurred at environmentally relevant concentrations. , However, the occurrences and hazards of other types and newer generations of cardiovascular and lipid-lowering drugs and their metabolites are rarely explored.…”

Section: Introductionmentioning

confidence: 99%

Residues of Cardiovascular and Lipid-Lowering Drugs Pose a Risk to the Aquatic Ecosystem despite a High Wastewater Treatment Ratio in the Megacity Shanghai, China

Zuo

Meng

Liang

et al. 2022

Environ. Sci. Technol.

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The residues of pharmaceuticals in surface waters of megacities and ecotoxicological implications are of particular concern. In this study, we combined field investigations and model simulations to explore the contamination of cardiovascular and lipid-lowering drugs, one group of the most prescribed medications globally, in surface waters of a typical megacity, Shanghai, with a high wastewater treatment ratio (≈96%). Among 26 target substances, 19 drugs were detected with aqueous concentrations ranging from 0.2 (ketanserin) to 715 ng/L (telmisartan). Of them, angiotensin II receptor antagonists, telmisartan and irbesartan, were dominant besides β-blockers. Spatial distribution analysis demonstrated their much higher levels in tributaries compared to the mainstream. The results of model simulations and field investigation revealed relatively low concentrations of cardiovascular and lipidlowering drugs in surface waters of Shanghai compared to other cities in highly developed countries, which is associated with low per capita usage in China. Ecotoxicological studies in zebrafish embryos further revealed developmental effects, including altered hatching success and heart rate, by irbesartan, telmisartan, lidocaine, and their mixtures at ng/L concentrations, which are typical levels in surface waters. Overall, the present results suggest that the high wastewater treatment ratio was not sufficient to protect fish species in the aquatic ecosystem of Shanghai. Exposure to cardiovascular and lipid-lowering drugs and associated risks will further increase in the future due to healthcare improvements and population aging.

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Metoprolol elicits neurobehavioral insufficiency and oxidative damage in nontarget Nauphoeta cinerea nymphs

Oyedele

Adedara

Ikeji

et al. 2023

Environmental Toxicology

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Metoprolol, a drug for hypertension and cardiovascular diseases, has become a contaminant of emerging concern because of its frequent detection in various environmental matrices globally. The dwindling in the biodiversity of useful insects owing to increasing presence of environmental chemicals is currently a great interest to the scientific community. In the current research, the toxicological impact of ecologically relevant concentrations of metoprolol at 0, 0.05, 0.1, 0.25, and 0.5 μg/L on Nauphoeta cinerea nymphs following exposure for 42 consecutive days was evaluated. The insects' behavior was analyzed with automated video‐tracking software (ANY‐maze, Stoelting Co, USA) while biochemical assays were done using the midgut, head and fat body. Metoprolol‐exposed nymphs exhibited significant diminutions in the path efficiency, mobility time, distance traveled, body rotation, maximum speed and turn angle cum more episodes, and time of freezing. In addition, the heat maps and track plots confirmed the metoprolol‐mediated wane in the exploratory and locomotor fitness of the insects. Compared with control, metoprolol exposure decreased acetylcholinesterase activity in insects head. Antioxidant enzymes activities and glutathione level were markedly decreased whereas indices of inflammation and oxidative injury to proteins and lipids were significantly increased in head, midgut and fat body of metoprolol‐exposed insects. Taken together, metoprolol exposure induces neurobehavioral insufficiency and oxido‐inflammatory injury in N. cinerea nymphs. These findings suggest the potential health effects of environmental contamination with metoprolol on ecologically and economically important nontarget insects.

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Metoprolol induces oxidative damage in common carp (Cyprinus carpio)

Cited by 15 publications

References 48 publications

Pharmaceuticals and personal care products and their sublethal and lethal effects in aquatic organisms

Pharmaceuticals and personal care products and their sublethal and lethal effects in aquatic organisms

Residues of Cardiovascular and Lipid-Lowering Drugs Pose a Risk to the Aquatic Ecosystem despite a High Wastewater Treatment Ratio in the Megacity Shanghai, China

Metoprolol elicits neurobehavioral insufficiency and oxidative damage in nontarget Nauphoeta cinerea nymphs

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