Metsulfuron-methyl induced physiological, behavioural and biochemical changes in exotic (Eisenia fetida) and indigenous (Metaphire posthuma) earthworm species: Toxicity and molecular docking studies

Chowdhary, Anu Bala; Singh, Jaswinder; Quadar, J.; Singh, Sharanpreet; Singh, Atamjit; Dutta, Rahil; Angmo, Deachen; Vig, Adarsh Pal

doi:10.1016/j.pestbp.2022.105276

Cited by 12 publications

(3 citation statements)

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“…In this study earthworms SOD activity is significantly accelerated by MPs on days 7 and 14 of exposure at all concentrations except 250 mg kg −1 . This increased SOD activity in the current study revealed that exposure to microplastic even at environmentally relevant concentrations promotes O 2 − generation thus stimulating the biosynthesis of SOD (Chowdhary et al, 2022;Zhang et al, 2014) and further, protecting against oxidative damage. The present study also observed the reduction in SOD activity in earthworms in all concentrations when compared with control on days 21 and 28 of the exposure period.…”

Section: Discussionsupporting

confidence: 56%

“…Our study indicated that microplastics stimulate the GST activity as the exposure period increased. LDPE had a significant effect on GST activity after 7 days of exposure Molecular docking studies is an effective tool to analyze the possible binding sites of a ligand in a particular enzyme and its interactions with the catalytic or non-catalytic sites at a molecular level that are responsible for the modulation of the activity of that enzyme (Chowdhary et al, 2022;Singh et al, 2022;Yuvaraj et al, 2021). Superoxide dismutase (SOD) catalyzes the conversion of superoxide radicals to oxygen and hydrogen peroxide resulting in the protection of cells from oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…Earthworm acts as a bio‐indicator of soil fauna and is the dominant biomass of invertebrates by serving a crucial function in maintaining soil health (Chowdhary et al., 2022). The existence of earthworms in soil signifies a healthy soil ecosystem (Nélieu et al., 2020).…”

Section: Introductionmentioning

confidence: 99%

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Biochemical responses, growth and reproduction of earthworm in low density polyethylene (LDPE)

Angmo

Dutta

Singh

et al. 2023

Environmental Quality Mgmt

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There is an unprecedented production of plastic that is accelerating its disposal while affecting the fitness of the terrestrial as well as the aquatic environment. The term microplastics refers to plastic fragments that are less than 5 mm in size and are widely distributed in the environment. Therefore, the present study intends to explore the biological response of earthworms (Eisenia fetida) toward different concentrations of low‐density polyethylene. E. fetida treated with low‐density polyethylene concentration (Control), 250 mg kg−1, 1000 mg kg−1, 6000 mg kg−1, 12,000 mg kg−1, and 25,000 mg kg−1. The above ratios were thoroughly mixed with 1kg of artificial soil and tested for growth, reproduction (cocoons and hatchling count), and enzymatic activities namely superoxide dismutase, guaiacol peroxidase, glutathione‐S‐transferase, and glutathione reductase and molecular docking studies. No mortality was observed during the exposure period at any concentrations. On the 28th day, when compared to the control the highest decrease in body weight of earthworms was observed in 25,000 mg (28.4%) followed by 12,000 mg (12.2%) and 6000 mg (3.4%). The cocoon and hatchlings significantly declined as the dose of microplastics increases. Enzymatic activity such as SOD and POD showed declined trend as the dose increased, while GST and GR increased with an increase in microplastic concentrations on 28th day. Furthermore, molecular docking showed that LDPE can modulate the activity of all four enzymes significantly.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%