METTLing in Stem Cell and Cancer Biology

Methylation of elongation factor 1A by yeast Efm4 or human eEF1A-KMT2 involves a beta-hairpin recognition motif and crosstalks with phosphorylation

“…Deciphering how these unique methyltransferases recognize and methylate eEF1A will be important for understanding how they can be targeted therapeutically. This is important as differential expression of eEF1A methyltransferases is associated with cancer progression ( 61 , 62 , 63 , 64 ). For example, increased eEF1A K55 methylation by overexpression of METTL13 plays a central role in the development of lung and pancreatic cancers ( 63 ).…”

Human seven-β-strand (METTL) methyltransferases - conquering the universe of protein lysine methylation

“…Therefore, it is important to note that the METTLs do not encompass a clearly defined MTase group, but that the ∼34 7BS MTases that were given a METTL name, constitute a rather arbitrary and historically selected subgroup within the 7BS MTases. Still, the METTLs are often referred to as a distinct MTase group in the literature, and specific review articles and omics studies have even been devoted to this subset of the 7BS MTases ( 124 , 125 , 126 , 127 ).…”

Epigenetic Regulation of CYP72A385-Mediated Metabolic Resistance to Novel Auxin Herbicide Florpyrauxifen-benzyl in Echinochloa crus-galli (L.) P. Beauv

“…In plants, DNA methylation homeostasis is mainly balanced by DNA methylation (DNA methyltransferases) and DNA demethylation [repressor of silencing 1 (ROS1)/Demeter family] processes . The DNA methyltransferases (DNMTs) family comprises a diverse group of methyltransferases that methylate nucleotides, proteins, and small molecules . In this study, we identified methyltransferase-like 7A ( EcMETTL7A ) involved in herbicide resistance.…”

“…27 The DNA methyltransferases (DNMTs) family comprises a diverse group of methyltransferases that methylate nucleotides, proteins, and small molecules. 28 In this study, we identified methyltransferase-like 7A (EcMETTL7A) involved in herbicide resistance. METTL7A is an N 6 -methyladenosine (m 6 A) methyltransferase that regulates gene expression through methylated DNA and lncRNA and plays a crucial role in translational regulation in stem cells and cancer cells.…”