Mg,Al layered double hydroxides with intercalated indomethacin: Synthesis, characterization, and pharmacological study

Arco, M. Del; Cebadera, E.; Gutiérrez, Sonia; Martı́n, Cristina; Montero, María J.; Rives, V.; Rocha, João; Sevilla, María A.

doi:10.1002/jps.20054

Cited by 179 publications

(65 citation statements)

References 30 publications

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“…When intercalated in the interlayer space of properl y functionalized LDH, it can provide sustained and controlled release of NSAIDs at specific sites [ 2 1,22] .Khan et al [ 23] intercalated a series of cardiovascular, antiinflammatory and analgesic agents like diclofenac, gemfibrozil, ibuprofen, naproxen, 2-propylpentanoic acid, 4 -biphenylacetic acid and tolfenamic acid into Li-Al-layered double hydroxide to formulate a novel tu nable drug delivery s ystem.Ambrogi et al [ 2 4 ] observed that ibuprofen anions exchanged all chloride ions of hydrotalcite-like compounds, producing an intercalation compound with a drug loading of 50% in w/w. Del Arco et al [25] carried out a in vivo pharmacological study of the interaction between hydrotalcite and indomethacin showing that intercalation of the drug reduces the ulcerating damage by it. Diclofenac has also been intercalated by several methods, making LDHs act as matrices for non-steroidal anti-inflammatory drugs [26] .…”

Section: Accepted Manuscriptmentioning

confidence: 99%

MgAl- Layered Double Hydroxide Nanoparticles for controlled release of Salicylate

Mondal

Dasgupta

Maji

2016

Materials Science and Engineering: C

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Section: Accepted Manuscriptmentioning

confidence: 99%

MgAl- Layered Double Hydroxide Nanoparticles for controlled release of Salicylate

Mondal

Dasgupta

Maji

2016

Materials Science and Engineering: C

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“…The profile of LDH nanoparticles loaded with other NSAID, such as Naproxen, Flurbiprofen, Ibuprofen, Diclofenac, Indomethacin, were widely investigated as well [42–48]. In combination of discussion about Fenbufen and Naproxen, there are three possible conclusions: (1) NSAID-LDH synthesis; Two different methods were employed for LDH synthesis, co-precipitation and reconstruction.…”

Section: The Delivery Of Non-steroidal Anti-inflammatory Drugs (Nsaids)mentioning

confidence: 99%

Potential for Layered Double Hydroxides-Based, Innovative Drug Delivery Systems

Zhang

et al. 2014

IJMS

104

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Layered Double Hydroxides (LDHs)-based drug delivery systems have, for many years, shown great promises for the delivery of chemical therapeutics and bioactive molecules to mammalian cells in vitro and in vivo. This system offers high efficiency and drug loading density, as well as excellent protection of loaded molecules from undesired degradation. Toxicological studies have also found LDHs to be biocompatible compared with other widely used nanoparticles, such as iron oxide, silica, and single-walled carbon nanotubes. A plethora of bio-molecules have been reported to either attach to the surface of or intercalate into LDH materials through co-precipitation or anion-exchange reaction, including amino acid and peptides, ATPs, vitamins, and even polysaccharides. Recently, LDHs have been used for gene delivery of small molecular nucleic acids, such as antisense, oligonucleotides, PCR fragments, siRNA molecules or sheared genomic DNA. These nano-medicines have been applied to target cells or organs in gene therapeutic approaches. This review summarizes current progress of the development of LDHs nanoparticle drug carriers for nucleotides, anti-inflammatory, anti-cancer drugs and recent LDH application in medical research. Ground breaking studies will be highlighted and an outlook of the possible future progress proposed. It is hoped that the layered inorganic material will open up new frontier of research, leading to new nano-drugs in clinical applications.

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“…Del Arco et al 58 realizaram um estudo in vivo do material obtido pela intercalação do anti-inflamatório indometacina em HDL de magnésio e alumínio (indometacina-HDL) comparando-o com a indometacina livre e a mistura física do HDL-carbonato com a indometacina. O fármaco indometacina, assim como todos os anti-inflamatórios não esteroidais não seletivos a COX-2 (enzima responsável pela resposta inflamatória no organismo), causam muitos problemas gastrointestinais.…”

Section: Diminuição De Efeitos Colaterais De Anti-inflamatórios (Lesõunclassified

Hidróxidos duplos lamelares: nanopartículas inorgânicas para armazenamento e liberação de espécies de interesse biológico e terapêutico

Cunha¹,

Ferreira²,

Constantino³

et al. 2010

Quím. Nova

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Recebido em 11/12/08; aceito em 1/7/09; publicado na web em 27/11/09 LAYERED DOUBLE HYDROXIDES: INORGANIC NANOPARTICLES FOR STORAGE AND RELEASE OF SPECIES OF BIOLOGICAL AND THERAPEUTIC INTEREST. Studies about the inorganic nanoparticles applying for non-viral release of biological and therapeutic species have been intensified nowadays. This work reviews the preparation strategies and application of layered double hydroxides (LDH) as carriers for storing, carrying and control delivery of intercalated species as drugs and DNA for gene therapy. LDH show low toxicity, biocompatibility, high anion exchange capacity, surface sites for functionalization, and a suitable equilibrium between chemical stability and biodegradability. LDH can increase the intercalated species stability and promote its sub-cellular uptake for biomedical purposes. Concerning the healthy field, LDH have been evaluated for clinical diagnosis as a biosensor component.Keywords: layered double hydroxides; inorganic carriers; drug release. INTRODUÇÃOO desenvolvimento de materiais híbridos é um campo de pesquisa que vem apresentando um desenvolvimento considerável nos últimos anos, devido principalmente ao fato de combinar o conhecimento tradicional com as novas abordagens e as modernas tecnologias. Esse desenvolvimento tem como objetivo atender à crescente demanda por novos materiais multifuncionais, com variadas aplicações em Física, Química, Biologia, Agricultura e Medicina. Particularmente, merece destaque o número de trabalhos que tratam da utilização de nanopartículas como cápsulas de armazenamento ou carregadores de espécies de interesse biológico e terapêutico. 1-3Diversos sistemas para liberação controlada de drogas têm sido engendrados e descritos, com suas vantagens e desvantagens comparadas, podendo ser classificados em quatro grupos principais: carregadores virais, compostos catiônicos orgânicos, proteínas recombinantes e nanopartículas inorgânicas. Exemplos recentes incluem: pontos quânticos (quantum dots) ou nanocompósitos magnético-fluorescentes; 4,5 géis poliméricos; 6,7 nanotubos de carbono ou sílica funcionalizados; 8 cápsulas multilamelares de polieletrólitos; 9 nanopartículas de ouro 10,11 e hidróxidos duplos lamelares (HDL). 12A Figura 1 mostra alguns exemplos de espécies nanoparticuladas de interesse na área médica. Particularmente, a busca por terapias antitumorais novas e racionais, aliadas às técnicas de diagnóstico mais seguras, envolve o planejamento e a obtenção de drogas ou fármacos alvo-específicos, isto é, que tenham alta especificidade para determinada biomolécula ou componente celular, podendo então serem transportados e liberados apenas em sítios escolhidos ou apropriados, aumentando sua eficácia terapêutica e diminuindo seus efeitos colaterais. Uma estratégia criativa é utilizar nanopartículas multifuncionais, capazes de carregar o fármaco e que, adicionalmente, contenham um composto (proteína, anticorpo ou ligante) reconhecido apenas por proteínas ou receptores associados a células tumorais (biomarcadores). Dessa ...

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Mg,Al layered double hydroxides with intercalated indomethacin: Synthesis, characterization, and pharmacological study

Cited by 179 publications

References 30 publications

MgAl- Layered Double Hydroxide Nanoparticles for controlled release of Salicylate

MgAl- Layered Double Hydroxide Nanoparticles for controlled release of Salicylate

Potential for Layered Double Hydroxides-Based, Innovative Drug Delivery Systems

Hidróxidos duplos lamelares: nanopartículas inorgânicas para armazenamento e liberação de espécies de interesse biológico e terapêutico

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