2017
DOI: 10.1016/j.fsi.2017.08.042
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MHC class II alpha, beta and MHC class II-associated invariant chains from Chinese sturgeon (Acipenser sinensis) and their response to immune stimulation

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Cited by 25 publications
(12 citation statements)
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“…Compared to that, in the octoploid A. schrenckii spleen, 490 unigenes of this KEGG pathway were identified after Y. ruckeri stimulation (Li et al . 2017b).…”
Section: Resultsmentioning
confidence: 99%
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“…Compared to that, in the octoploid A. schrenckii spleen, 490 unigenes of this KEGG pathway were identified after Y. ruckeri stimulation (Li et al . 2017b).…”
Section: Resultsmentioning
confidence: 99%
“…Li et al . (2017b) characterized MHC II α‐, β‐, and γ‐chain from molecular features in A. sinensis . Expression analysis upon stimulation with poly I:C and with the inactivated Gram‐negative bacterium Vibrio anguillarum revealed a wide tissue distribution, as MHC II α, β and γ genes were expressed in brain, heart, intestine, head kidney, liver, muscle and spleen, with highest expression levels in spleen followed by intestine and head kidney.…”
Section: Resultsmentioning
confidence: 99%
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“…Some studies have shown that tuna showed significant upregulation of the CD8 gene after inoculation with alloantigens ( 56 , 57 ), and in zebrafish, the CD8 gene also showed significant upregulation after challenge ( 58 ). MHC-II molecule is mainly to deliver processed antigen fragments to CD4+ T cells during the initiation phase of the immune response and to modulate humoral immunity ( 59 ). In a previous report, it was shown that vaccination upregulated MHC-II mRNA expression level in the head kidney ( 60 ), and in another experiment the number of MHC-II positive cells was increased at the site of infection, suggesting that these cells enhance the immune response by antigen presentation capacity to induce antibody responses ( 61 ).…”
Section: Discussionmentioning
confidence: 99%
“…Then, the signal is transmitted to IFN regulatory factor 3 (IRF3) to activate MITA (also known as STING, ERIS or MYPS) and TANK binding kinase 1 (TBK1). Major histocompatibility complex class II (MHCII), MHCII, plays an important role in the adaptive immune response by presenting antigens to CD4 + T lymphocytes [72], and CD4L is a subset of T helper cells and [73] is a key marker molecule, which provides a basis for solving the participation of T cells [74]. Consistent with the immune response, the grass carp taking B. s -CotC-VP56-2 rapidly increased IFN1 and MHC-II on the third day, which was significantly higher than the other groups.…”
Section: Discussionmentioning
confidence: 99%