2024
DOI: 10.3389/fimmu.2024.1440887
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MICA and NKG2D gene polymorphisms influence graft survival, and response to therapy in kidney transplantation

Roberto Littera,
Stefano Mocci,
Davide Argiolas
et al.

Abstract: BackgroundAntibody-mediated rejection is a significant cause of kidney transplant failure. Recent studies have shown that the MHC class I MICA gene influences the transplantation outcome. However, the role of the primary MICA receptor, NKG2D, has yet to be explored.AimWe aimed to investigate the correlation between recipient/donor MICA allele matching and NKG2D genotype with the risk of antibody-mediated rejection and their potential clinical effects and implications for organ maintenance therapy.MethodsOf the… Show more

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