Micaryolanes A and B, Two New Caryolane‐Type Sesquiterpenoids from Marine <i>Streptomyces</i> sp. AH25

Wu, Jiequn; Zhu, Yi; Zhang, Meng-Xue; Li, Hongji; Sun, Peng

doi:10.1002/cbdv.202000769

Cited by 4 publications

(3 citation statements)

References 35 publications

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“…YIM 56130 [ 94 ], Streptomyces sp. AH25 [ 108 ], S. anulatus YIM 101882 [ 92 ], and S. albolongus YIM 101047 [ 73 ]. Bacaryolanes A-C ( 100 – 102 ), enantioisomers of plant caryolans, were separated from the fermentation broth of Streptomyces sp.…”

Section: Terpene Biosynthesis By Actinomycetesmentioning

confidence: 99%

Actinomycetes as Producers of Biologically Active Terpenoids: Current Trends and Patents

et al. 2023

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Terpenes and their derivatives (terpenoids and meroterpenoids, in particular) constitute the largest class of natural compounds, which have valuable biological activities and are promising therapeutic agents. The present review assesses the biosynthetic capabilities of actinomycetes to produce various terpene derivatives; reports the main methodological approaches to searching for new terpenes and their derivatives; identifies the most active terpene producers among actinomycetes; and describes the chemical diversity and biological properties of the obtained compounds. Among terpene derivatives isolated from actinomycetes, compounds with pronounced antifungal, antiviral, antitumor, anti-inflammatory, and other effects were determined. Actinomycete-produced terpenoids and meroterpenoids with high antimicrobial activity are of interest as a source of novel antibiotics effective against drug-resistant pathogenic bacteria. Most of the discovered terpene derivatives are produced by the genus Streptomyces; however, recent publications have reported terpene biosynthesis by members of the genera Actinomadura, Allokutzneria, Amycolatopsis, Kitasatosporia, Micromonospora, Nocardiopsis, Salinispora, Verrucosispora, etc. It should be noted that the use of genetically modified actinomycetes is an effective tool for studying and regulating terpenes, as well as increasing productivity of terpene biosynthesis in comparison with native producers. The review includes research articles on terpene biosynthesis by Actinomycetes between 2000 and 2022, and a patent analysis in this area shows current trends and actual research directions in this field.

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Section: Terpene Biosynthesis By Actinomycetesmentioning

confidence: 99%

Actinomycetes as Producers of Biologically Active Terpenoids: Current Trends and Patents

et al. 2023

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“…Therefore, marine-derived Streptomyces and other actinobacteria are regarded as a valuable resource for the discovery of novel bioactive compounds with potential therapeutic applications [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. Marineosins A and B are two structurally related compounds that were first discovered from this strain.…”

Section: Introductionmentioning

confidence: 99%

Actinoquinazolinone, a New Quinazolinone Derivative from a Marine Bacterium Streptomyces sp. CNQ-617, Suppresses the Motility of Gastric Cancer Cells

Pulat,

Kim,

Hillman

et al. 2023

Marine Drugs

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A HPLC-UV guided fractionation of the culture broth of Streptomyces sp. CNQ-617 has led to the isolation of a new quinazolinone derivative, actinoquinazolinone (1), as well as two known compounds, 7-hydroxy-6-methoxy-3,4-dihydroquinazolin-4-one (2) and 7-methoxy-8-hydroxy cycloanthranilylproline (3). The interpretation of 1D, 2D NMR, and MS spectroscopic data revealed the planar structure of 1. Furthermore, compound 1 suppressed invasion ability by inhibiting epithelial–mesenchymal transition markers (EMT) in AGS cells at a concentration of 5 µM. In addition, compound 1 decreased the expression of seventeen genes related to human cell motility and slightly suppressed the signal transducer and activator of the transcription 3 (STAT3) signal pathway in AGS cells. Together, these results demonstrate that 1 is a potent inhibitor of gastric cancer cells.

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“…With the detailed investigation on marine microorganisms, marine-derived actinomycetes have proven to be an inexhaustible source for bioactive secondary metabolites [ 9 ]. A number of new bioactive compounds were characterized from marine-derived Streptomyces , such as isoquinolinequinones [ 10 ], terpenoid derivatives [ 11 , 12 ], angucycline derivatives [ 13 , 14 , 15 ], glycosylated aromatic polyketides [ 16 ], bicyclic peptides [ 17 ], depsipeptides [ 18 ], benzodiazepines [ 19 ], and piericidin derivatives [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Unique Cyclized Thiolopyrrolones from the Marine-Derived Streptomyces sp. BTBU20218885

Song

Zhang

et al. 2022

Marine Drugs

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Two new cyclized thiolopyrrolone derivatives, namely, thiolopyrrolone A (1) and 2,2-dioxidothiolutin (2), together with the kn own compound, thiolutin (3) were identified from a marine-derived Streptomyces sp. BTBU20218885, which was isolated from a mud sample collected from the coastal region of Xiamen, China. Their chemical structures were determined using spectroscopic data, including HRESIMS, 1D and 2D NMR techniques. 1 possessed a unique unsymmetrical sulfur-containing thiolopyrrolone structure. All the compounds were tested for bioactivities against Staphylococcus aureus, Escherichia coli, Bacille Calmette–Guérin (BCG), Mycobacterium tuberculosis, and Candida albicans. 1 displayed antibacterial activities against BCG, M. tuberculosis, and S. aureus with minimum inhibitory concentration (MIC) values of 10, 10, and 100 μg/mL, respectively. Thiolutin (3) showed antibacterial activities against E. coli, BCG, M. tuberculosis, and S. aureus with MIC values of 6.25, 0.3125, 0.625, and 3.125 μg/mL, respectively.

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Micaryolanes A and B, Two New Caryolane‐Type Sesquiterpenoids from Marine Streptomyces sp. AH25

Cited by 4 publications

References 35 publications

Actinomycetes as Producers of Biologically Active Terpenoids: Current Trends and Patents

Actinomycetes as Producers of Biologically Active Terpenoids: Current Trends and Patents

Actinoquinazolinone, a New Quinazolinone Derivative from a Marine Bacterium Streptomyces sp. CNQ-617, Suppresses the Motility of Gastric Cancer Cells

Unique Cyclized Thiolopyrrolones from the Marine-Derived Streptomyces sp. BTBU20218885

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