MICB polymorphism in a southern Chinese Han population: The identification of two new MICB alleles, MICB∗005:06 and MICB∗026

Liu, Xue Xiang; Li, Lixin; Pan, Feng; Tian, Wei

doi:10.1016/j.humimm.2012.05.008

Cited by 18 publications

(15 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The allele frequency of MICB*005:02 was the highest in the patient group and control group (42% vs. 51%), and the frequencies between the two groups were not significantly different. These results are consistent with the reports of Liu et al., namely, that the MICB*005:02 allele is the most common allele in the southern Han Chinese population (Liu, Li, Pan, & Tian, ). Some studies also reported that MICB*002 and MICB*008 were associated with coeliac disease susceptibility (Rodriguez‐Rodero et al., ).…”

Section: Discussionsupporting

confidence: 93%

The association between MICA/MICB polymorphism and respiratory syncytial virus infection in children

Luo

Guo

Peng

et al. 2017

Int J Immunogenetics

View full text Add to dashboard Cite

MICA/MICB gene polymorphisms are related to several cancers and infectious diseases, but there are no reports on the association between MICA/MICB gene polymorphisms and respiratory syncytial virus (RSV) infection. To clarify the association between MICA/MICB gene polymorphisms and infection of RSV in children, we collected fresh blood samples from paediatric patients with and without pneumonia after RSV infection. The MICA/MICB alleles were characterized by PCR sequence-specific primers (PCR-SSP) and PCR sequence-based genotyping (PCR-SBT), and then, the frequency of the MICA/MICB alleles and haplotypes was calculated. The results showed that the frequencies of MICA*002:01 and MICA-A9 in RSV-infected patients were significantly lower than in controls (9% vs. 20%, pc = 0.04). The allele frequency of MICA*002:01 in pneumonia patients (8%) and nonpneumonia patients (9%) was significantly lower than in controls (20%, pc = 0.02). MICA*002:01-MICB*008(Δrel = 0.616), MICA*009-MICB*016 (Δrel = 0.506), and MICA*045-MICB*014 (Δrel = 0.700) showed linkage disequilibrium in patients infected with RSV. The haplotype frequency of MICA*002:01-MICB*005:02 in RSV-infected patients was significantly lower than in controls (10% vs. 16%, pc = 0.033). In conclusion, allele MICA*002:01/A9 and haplotype MICA*002:01-MICB*005:02 were negatively associated with RSV respiratory tract infections.

show abstract

Section: Discussionsupporting

confidence: 93%

The association between MICA/MICB polymorphism and respiratory syncytial virus infection in children

Luo

Guo

Peng

et al. 2017

Int J Immunogenetics

View full text Add to dashboard Cite

show abstract

“…The major histo compatibility complex class I-related chain B (MICB) is targeted by miR-BART2-5p, preventing natural killer (NK) cells from recognizing EBV-infected cells. In virus infections and tumor proliferation, MICB expression increases, and it has been found to activate NK and T cells, thereby initiating the immune reaction (Diefenbach et al, 2000;Nachmani et al, 2009;Lisnic et al, 2010;Liu et al, 2012). EBV miR-BART1, miR-BART2, and miR-BART22 co-target interleukin-12 (IL-12), leading to decreased T cell differentiation, activation, and recognition at different stages of infection and malignant disease (Albanese et al, 2016).…”

Section: Ebv-encoded Mirnas Regulate the Immune Response By Targetingmentioning

confidence: 99%

An update: Epstein-Barr virus and immune evasion via microRNA regulation

Zuo

Yue

et al. 2017

Virol. Sin.

View full text Add to dashboard Cite

Epstein-Barr virus (EBV) is an oncogenic virus that ubiquitously establishes life-long persistence in humans.To ensure its survival and maintain its B cell transformation function, EBV has developed powerful strategies to evade host immune responses. Emerging evidence has shown that microRNAs (miRNAs) are powerful regulators of the maintenance of cellular homeostasis. In this review, we summarize current progress on how EBV utilizes miRNAs for immune evasion. EBV encodes miRNAs targeting both viral and host genes involved in the immune response. The miRNAs are found in two gene clusters, and recent studies have demonstrated that lack of these clusters increases the CD4 + and CD8 + T cell response of infected cells. These reports strongly indicate that EBV miRNAs are critical for immune evasion. In addition, EBV is able to dysregulate the expression of a variety of host miRNAs, which influence multiple immune-related molecules and signaling pathways. The transport via exosomes of EBV-regulated miRNAs and viral proteins contributes to the construction and modification of the inflammatory tumor microenvironment. During EBV immune evasion, viral proteins, immune cells, chemokines, pro-inflammatory cytokines, and pro-apoptosis molecules are involved. Our increasing knowledge of the role of miRNAs in immune evasion will improve the understanding of EBV persistence and help to develop new treatments for EBV-associated cancers and other diseases.

show abstract

“…A growing body of research now shows that MICB polymorphism is related to certain diseases . However, as HLA‐MICB‐MICA haplotypes have been reported in different people , this disease association may be secondary and due to LD with HLA alleles. Some reported MICA‐MICB haplotypes were confirmed in our study, for example, MICB*005:02 was in strong LD with MICA*010 , and MICB*008 displayed distinct LD patterns with MICA*002:01 in the Li population.…”

Section: Mica Allele Frequencies In Hainan LI Populationmentioning

confidence: 99%

MIC gene polymorphism and haplotype diversity in Li nationality of Southern China

et al. 2014

View full text Add to dashboard Cite

Here, we report for the first time the polymorphisms of MICA and MICB in a healthy Li population of 344 unrelated individuals. By using polymerase chain reaction-sequence specific priming (PCR-SSP) and sequence-based typing (PCR-SBT), 17 MICA-sequence alleles and 5 MICA-STR (short tandem repeats, STR) alleles, as well as 17 MICB alleles were detected, among which MICA*010, MICA*A4 and MICB*005:02 were the most frequent alleles. In addition, linkage disequilibrium was investigated and the most common two-locus haplotypes were MICB*005:02-MICA*010 and MICB*008-MICA*002:01. These results present informative genetic markers for the investigation of possible origins and the evolution of MHC class I haplotypes in the Li population.

show abstract

MICB polymorphism in a southern Chinese Han population: The identification of two new MICB alleles, MICB∗005:06 and MICB∗026

Cited by 18 publications

References 34 publications

The association between MICA/MICB polymorphism and respiratory syncytial virus infection in children

The association between MICA/MICB polymorphism and respiratory syncytial virus infection in children

An update: Epstein-Barr virus and immune evasion via microRNA regulation

MIC gene polymorphism and haplotype diversity in Li nationality of Southern China

Contact Info

Product

Resources

About