MICB0106 gene polymorphism is associated with ulcerative colitis in central China

Li, Yi; Xia, Bing; Lü, Min; Ge, Liuqing; Zhang, Xiaolian

doi:10.1007/s00384-009-0787-y

Cited by 16 publications

(15 citation statements)

References 39 publications

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“…However, several studies of the MICB locus have shown positive disease associations. MICB*008 was linked to Crohn's disease in a Spanish population (17) and was positively associated with ulcerative colitis in a central Chinese population (19). In addition, MICB*004 was reported to be associated with multiple sclerosis and rheumatoid arthritis in a Spanish population (13, 16), and MICB*005:02 was negatively associated with cervical cancer in northeastern Thai women (20).…”

Section: Discussionmentioning

confidence: 99%

MICB polymorphisms and haplotypes with MICA and HLA alleles in Koreans

Hwan

Sohn

et al. 2011

Tissue Antigens

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Major histocompatibility complex (MHC) class I chain-related gene B (MICB) is located within the human MHC class I region. The location of MICB in the MHC region may imply the presence of linkage disequilibrium with polymorphic MICA and human leukocyte antigen (HLA) loci. MICB is also polymorphic; however, MICB polymorphisms have not been investigated in Koreans. Using sequence-based typing (SBT), we estimated the allelic frequencies of MICB and haplotypes with MICA, HLA-B, and HLA-DRB1 at high resolution in a population of 139 unrelated Korean individuals. Eight MICB alleles were identified. The most frequent allele was MICB*005:02/*010 (57.2%), followed by *002 (11.5%), *004 (8.3%), *005:03 (8.3%), and *008 (6.8%). The most common two-locus haplotypes were MICB*005:02/*010-MICA*010 (19.4%), MICB*005:02/*010-DRB1*15:01 (6.5%), and MICB*005:02/*010-B*15:01 (10.4%); the most common three-locus haplotypes were B*15:01-MICA*010-MICB*005:02/*010 (5.8%) and MICA*010-MICB*005:02/*010-DRB1*04:06 (10.4%); and the most common four-locus haplotype was B*15:01-MICA*010-MICB*005:02/*010-DRB1*04:06 (5.8%). This is the first study to provide information about MICB allele frequencies and haplotypes with HLA in Koreans. These study results should help understand mechanisms of disease association between the MICB locus and neighboring loci in Koreans.

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Section: Discussionmentioning

confidence: 99%

MICB polymorphisms and haplotypes with MICA and HLA alleles in Koreans

Hwan

Sohn

et al. 2011

Tissue Antigens

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“…Past reports on the allelic distribution of MICB were of little information with regard to disease. A growing body of research now shows that MICB polymorphism is related to certain diseases . However, as HLA‐MICB‐MICA haplotypes have been reported in different people , this disease association may be secondary and due to LD with HLA alleles.…”

Section: Mica Allele Frequencies In Hainan LI Populationmentioning

confidence: 99%

MIC gene polymorphism and haplotype diversity in Li nationality of Southern China

et al. 2014

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Here, we report for the first time the polymorphisms of MICA and MICB in a healthy Li population of 344 unrelated individuals. By using polymerase chain reaction-sequence specific priming (PCR-SSP) and sequence-based typing (PCR-SBT), 17 MICA-sequence alleles and 5 MICA-STR (short tandem repeats, STR) alleles, as well as 17 MICB alleles were detected, among which MICA*010, MICA*A4 and MICB*005:02 were the most frequent alleles. In addition, linkage disequilibrium was investigated and the most common two-locus haplotypes were MICB*005:02-MICA*010 and MICB*008-MICA*002:01. These results present informative genetic markers for the investigation of possible origins and the evolution of MHC class I haplotypes in the Li population.

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“…For example, specific MICA alleles are overrepresented in rheumatoid arthritis, inflammatory bowel disease and type 1 diabetes patients, implicating a role in disease pathogenesis (24,25). Likewise, MICB polymorphisms are also associated with celiac disease, ulcerative colitis, and multiple sclerosis (26–28).…”

Section: Chromosome 6q251 (Ulbp6/ulbp3)mentioning

confidence: 99%

The genetics of alopecia areata: What's new and how will it help our patients?

Petukhova

Cabral²,

Mackay‐Wiggan³

et al. 2011

Dermatologic Therapy

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In the United States, alopecia areata (AA) is the most prevalent autoimmune disease, affecting approximately 5.3 million people, including males and females of all ages and across all ethnic groups. AA affects more individuals than most other autoimmune diseases combined, and yet despite its prevalence, there is little information on the underlying pathogenesis and there are currently no evidence-based treatments available to treat or cure this disease. Genetics has provided a valuable tool for gaining insight into disease pathology. We recently completed the first genome-wide association study (GWAS) in AA and successfully identified at least eight regions in the genome with evidence for association to AA. Importantly, this work identifies a discrete set of genes, some of which have been well studied within the context of other autoimmune diseases and already have targeted therapies available or in development. The insight that we have gained through our GWAS sets the stage for the rational development of novel effective therapeutic approaches and heralds in an exciting new era with the commencement of translational research in AA based on genetic findings.

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MICB0106 gene polymorphism is associated with ulcerative colitis in central China

Cited by 16 publications

References 39 publications

MICB polymorphisms and haplotypes with MICA and HLA alleles in Koreans

MICB polymorphisms and haplotypes with MICA and HLA alleles in Koreans

MIC gene polymorphism and haplotype diversity in Li nationality of Southern China

The genetics of alopecia areata: What's new and how will it help our patients?

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