“…Note that low scramblase activity is a prerequisite for preserving the asymmetric lipid arrangements created by unidirectional P 4 -ATPase flippases that operate in late secretory and endosomal orgnanelles. Yabas et al, 2011;Segawa et al, 2014;Yabas et al, 2014 C. elegans A. thaliana Human CDC50A, CDC50B and CDC50C are also referred to as TMEM30A, TMEM30B and TMEM30C, respectively. SV, postGolgi secretory vesicle; PM, plasma membrane; Disk, photo-receptor disk membrane; EE, early endosome; RE, recycling endosome; LE, late endosomes; CL, cardiolipin; LPC, lyso-phosphatidylcholine; LPE, lyso-phosphatidylethanolamine; LPS, lyso-phosphatidylserine; n.d., not defined.…”