Micellization and gelation in block copolymer systems containing local anesthetics

Scherlund, Marie; Brodin, Arne; Malmsten, Martin

doi:10.1016/s0378-5173(00)00589-5

Cited by 66 publications

(45 citation statements)

References 48 publications

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“…31 • C to below 8 • C, while the peak intensity and peak area increase dramatically. The temperature range of this process, as defined by the temperature interval from T onset to T endset , is around 14-16 • C. This concentration dependent decrease in CMT is in agreement with previous studies (Alexandridis et al, 1994;Scherlund et al, 2000). The transition of highly concentrated samples at elevated temperatures to the gel-state can also be discerned, as a small endothermic peak at the high temperature shoulder of the micellization peak.…”

Section: Differential Scanning Calorimetrysupporting

confidence: 91%

“…P407 gels have also been evaluated for ocular delivery of pilocarpine (Desai and Blanchard, 1998), periodontal delivery of local anaesthetics (Scherlund et al, 2000) and the delivery of proteins and peptides (Liu et al, 2007). A comprehensive review of applications of P407 gels in pharmaceutical formulation has been published (Escobar-Chavez et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Effect of DMSO on micellization, gelation and drug release profile of Poloxamer 407

Ur-Rehman

Tavelin

Gröbner

2010

International Journal of Pharmaceutics

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Section: Differential Scanning Calorimetrysupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Effect of DMSO on micellization, gelation and drug release profile of Poloxamer 407

Ur-Rehman

Tavelin

Gröbner

2010

International Journal of Pharmaceutics

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“…Poly(ethylene-covinyl acetate) and poly(oxyethylene-b-oxypropylene-b-oxyethylene) are block copolymers which have numerous and recognised applications in the development of CDDSs mainly because of their biocompatibility, processability (e.g. extrusion) and proved long-term release properties [22][23][24][25][26].…”

mentioning

confidence: 99%

Supercritical solvent impregnation of poly(ɛ-caprolactone)/poly(oxyethylene-b-oxypropylene-b-oxyethylene) and poly(ɛ-caprolactone)/poly(ethylene-vinyl acetate) blends for controlled release applications

Natu

Gil

Sousa

2008

The Journal of Supercritical Fluids

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Please cite this article as: M.V. Natu, M.H. Gil, H.C. de Sousa, Supercritical Solvent Impregnation of Poly( -caprolactone/poly(oxyethylene-b-oxypropylene-boxyethylene) and Poly( -caprolactone/poly(ethylene-vinyl acetate) Blends for Controlled Release Applications, The Journal of Supercritical Fluids (2007Fluids ( ), doi:10.1016Fluids ( /j.supflu.2008 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractPoly(ε-caprolactone) blends were successfully impregnated with timolol maleate, an antiglaucoma drug, using a Supercritical Solvent Impregnation (SSI) technique. Supercritical fluid impregnation efficiency results suggested that the best impregnating conditions were obtained when a cosolvent was used and when specific drug-polymer interactions occurred as a consequence of different chemical structures due to polymer blending. Pressure can be either a favourable factor, when there is enough drug affinity for the polymers, or an unfavourable factor when weaker bonding is involved. In order to determine the relative * ManuscriptPage 2 of 40 A c c e p t e d M a n u s c r i p t 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 2 hydrophilicity/hydrophobicity of the blends, contact angle analysis was performed, while crystallinity determination was also useful to understand the obtained release profiles.Drug loading, heterogeneous/homogeneous dispersion of drug inside the matrix, hydrophilicity, crystallinity, all seem to influence the obtained drug release rates. The "in vitro" release results suggested that a sustained drug release rate can be obtained by changing the SSI operational conditions and by modulating the composition of blends, as a mean to control crystallinity, hydrophilicity and drug affinity for the polymer matrix. After a first day burst release, all samples showed a sustained release profile (1.2-4 µg/ml/day, corresponding to a mass of 3-10 µg/day) which is between the therapeutic and toxic levels of timolol maleate, during a period of 1 month. These drug-loaded polymeric matrices can be a feasible alternative treatment modality for the conventional repeated daily administration of eye drops.

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“…Kayali et al [6] used lamellar liquid crystal composed of EO 27 PO 61 EO 27 as solvent in alternative to ethanol to solubilize some fragrance substances (limonene, phenethylalcohol and benzaldeyde). Solubilization, stabilization and delivery of hydrophobic drugs in aggregates of Pluronics were exploited [7][8][9]. Finally, the affinity of materials environmentally significant [10][11][12][13][14][15] to Pluronics micelles was investigated.…”

Section: Introductionmentioning

confidence: 99%

Copolymers sensitive to temperature and pH in water and in water+oil mixtures: A DSC, ITC and volumetric study

Lisi

Giammona

Lazzara

et al. 2011

Journal of Colloid and Interface Science

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Micellization and gelation in block copolymer systems containing local anesthetics

Cited by 66 publications

References 48 publications

Effect of DMSO on micellization, gelation and drug release profile of Poloxamer 407

Effect of DMSO on micellization, gelation and drug release profile of Poloxamer 407

Supercritical solvent impregnation of poly(ɛ-caprolactone)/poly(oxyethylene-b-oxypropylene-b-oxyethylene) and poly(ɛ-caprolactone)/poly(ethylene-vinyl acetate) blends for controlled release applications

Copolymers sensitive to temperature and pH in water and in water+oil mixtures: A DSC, ITC and volumetric study

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