Micellization of a cationic gemini surfactant in aqueous solutions with different alkanols and alkanediols as additives: Effect of nonpolar chain and position of hydroxyl groups

Chavda, Suresh; Bahadur, Pratap

doi:10.1016/j.molliq.2011.04.018

Cited by 26 publications

(21 citation statements)

References 55 publications

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“…However, F4 acted retardation effects more obviously than F5 suggested that 1,4-cyclohexanedicarboxylic acid without 1,2-hexanediol in the formulation would exert a more intense effect on the penetration of MTZ. Roberts pointed out that passing through skin of a permeant depended on its H-bonding capacity, and the size of the molecule as defined by its molecular weight would also influence the process of diffusion (10). The molecular weight o f 1 , 4 -c y c l o h e x a n e d i o l , 1 , 2 -h e x a n e d i o l , a n d 1 , 4 -cyclohexanedicarboxylic acid were estimated to144.21, 118.17, and 168.24, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…Retardants reported were similar to certain enhancers in structure, and structure-activity relationship of both enhancers and retardants would influence penetration effect (7)(8)(9)(10). Most of these retardants reported had the common feature: they formed H-bond crosslinking with ceremides 6, which possess the strongest H-bonding capability in the SC (11).…”

Section: Introductionmentioning

confidence: 89%

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Effect of Hydroxyl Groups and Rigid Structure in 1,4-Cyclohexanediol on Percutaneous Absorption of Metronidazole

et al. 2014

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Abstract. In a previous study, a synergistic retardation effect of 1,4-cyclohexanediol and 1,2-hexanediol on percutaneous absorption and penetration of metronidazole (MTZ) was discovered. A complex formation between 1,4-cyclohexanediol and 1,2-hexanediol was proposed to be responsible for the observed effect. The objective of this study was to investigate the necessity of hydroxyl group and the ring structure in 1,4-cyclohexanediol on percutaneous absorption and penetration of MTZ. Eleven formulations were studied in an in vitro porcine skin model using glass vertical Frans Diffusion Cell. 1,4-Cyclohexanediol was changed into 1,4-cyclohexanedicarboxylic acid, trans (and cis)-1,2-cyclohexanediol and 1,6-hexanediol, respectively, to study if H-bonding or ring structure would influence the retardation effect. MTZ was applied at infinite dose (100 mg), which corresponded to 750 μg of MTZ. Based on modifier ratios (MR) calculated by the flux values, the retardation effect on percutaneous absorption and penetration of MTZ was found in the formulations containing 1,4-cyclohexanedicarboxylic acid or cis-1,2-cyclohexanediol (MR values were 0.47 for which only contains 1,4-cyclohexanedicarboxylic acid, 0.74 for the formulation containing both 1,4-cyclohexanedicarboxylic acid and 1,2-hexanediol, and 0.90 for the formulation containing cis-1,2-cyclohexanediol and 1,2-hexanediol, respectively). The results showed that the hydroxyl group and structure of 1,4-cyclohexanediol played a significant role in retardation effects and provided valuable insight on the mechanisms of retardation effect through structure-activity relationships.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 89%

Effect of Hydroxyl Groups and Rigid Structure in 1,4-Cyclohexanediol on Percutaneous Absorption of Metronidazole

et al. 2014

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“…Surfactants or surface active agents have a wide range of applications in industries, agriculture, textile, detergent, food, cosmetics and the drug or pharmaceutical [1,2]. Surfactants consist of a long non-polar or hydrophobic such as single or double bonds, saturated and unsaturated hydrocarbon tail and a polar or hydrophilic with ionic, nonionic or zwitterion head groups [3].…”

Section: Introductionmentioning

confidence: 99%

“…Antibacterial, antistatic, corrosion inhibitory, dispersants, emulsifying, wetting and solubilizing agent's properties of cationic surfactants are well known [1,4,5]. However, in last decade, the cationic surfactants have attracted immense interest in the development of methods for separation, purification and extraction of DNA.…”

Section: Introductionmentioning

confidence: 99%

Determination of Critical Micel Concentration of PEG-10 Tallow Propane Amine: Effects of Salt and pH

Ataci¹,

Saraç²

2014

AJAC

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Most applications of surfactants depend on formation and characteristics of micelle. In this study we measured critical micelle concentration (CMC) of cationic surfactant N, N', N'-polyethylene (10)-N tallow-1, 3-di amine propane (PEG-10 tallow) in aqua solution by using electrical conductivity and surface tension methods. The CMC value of PEG-10 tallow with two different methods was found very close to 1.40 × 10 −3 M with electrical conductivity, and 1.41 × 10 −3 M with surface tension. It also investigated the effect of inorganic salt (NaCl) and pH on micellization of cationic surfactant PEG-10 tallow. With increasing addition of NaCl, formation of micelle structure resulted in a higher CMC. However, at low salt concentrations smaller CMC value was observed comparing the critical micelle concentration of individual PEG-10 tallow. When it comes to the effect of changing pH in CMC of the PEG-10 tallow , it was clearly found that micelle formation or CMC of surfactant was independent on alkaline pH (between 6 and 10), but it was dependent on acidic pH (below 5).

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“…As indicated from CMC values of surfactants in presence of alcohols, hydrophobic alcohols cause a larger decrease in the CMC than hydrophilic ones. 36 Alternatively, more hydrophobic alcohols have higher partition coefficient and they get solubilized in surfactant micelles at much lower concentrations than the shorter chain alcohols.…”

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confidence: 99%

1-Hexanol triggered structural characterization of the worm-like micelle to vesicle transitions in cetyltrimethylammonium tosylate solutions

et al. 2015

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The cationic surfactant cetyltrimethylammonium tosylate (CTAT) forms highly viscous/viscoelastic solutions and worm-like micelles at relatively low concentrations. The effect of 1-alkanols with short to long alkyl chains viz. ethanol, 1-butanol, 1-hexanol and 1-octanol on CTAT micelles was examined. In particular, a detailed study on the effect of 1-hexanol was carried out by viscosity, cryogenic transmission electron microscopy (cryo-TEM), nuclear magnetic resonance (NMR) and small-angle neutron scattering (SANS) to observe microstructural changes in CTAT micelles. 1-Hexanol displays a distinct interaction with CTAT micelles strongly dependent on CTAT concentration. Up to a certain critical CTAT concentration, 1-hexanol molecules penetrate into the micelles and show growth.Characterization by direct cryo-TEM imaging implies that upon progressive addition of 1-hexanol, worm-like CTAT micelles first grow and finally transform into vesicles. The course of vesicle formation was followed by SANS measurements. The site of 1-hexanol in the micelles close to the palisade layer was evaluated using 2D NMR. This study devotes a fundamental knowledge for controlling the shape and size of worm-like micelles that find many industrial applications particularly in personal-and home-care products.

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Micellization of a cationic gemini surfactant in aqueous solutions with different alkanols and alkanediols as additives: Effect of nonpolar chain and position of hydroxyl groups

Cited by 26 publications

References 55 publications

Effect of Hydroxyl Groups and Rigid Structure in 1,4-Cyclohexanediol on Percutaneous Absorption of Metronidazole

Effect of Hydroxyl Groups and Rigid Structure in 1,4-Cyclohexanediol on Percutaneous Absorption of Metronidazole

Determination of Critical Micel Concentration of PEG-10 Tallow Propane Amine: Effects of Salt and pH

1-Hexanol triggered structural characterization of the worm-like micelle to vesicle transitions in cetyltrimethylammonium tosylate solutions

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