2019
DOI: 10.1016/j.colsurfb.2018.11.048
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Miconazole loaded chitosan-based nanoparticles for local treatment of vulvovaginal candidiasis fungal infections

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Cited by 47 publications
(15 citation statements)
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“…Similar levels of biochemical parameters of kidneys and liver and fractional DNA content in mice bone marrow cells were shown in all treatment groups, stipulating the absence of nephrotoxicity, hepatoxicity and genotoxicity with chitosan-based nanoparticles containing miconazole nitrate. These data indicate the feasibility of this formulation to emerge as a promising alternative for treatment of VVC [75].…”
Section: Nanocarriersmentioning
confidence: 70%
“…Similar levels of biochemical parameters of kidneys and liver and fractional DNA content in mice bone marrow cells were shown in all treatment groups, stipulating the absence of nephrotoxicity, hepatoxicity and genotoxicity with chitosan-based nanoparticles containing miconazole nitrate. These data indicate the feasibility of this formulation to emerge as a promising alternative for treatment of VVC [75].…”
Section: Nanocarriersmentioning
confidence: 70%
“…To improve the therapeutic effects of antifungal agents, PNs have been widely used in the treatment of candidiasis, including oral candidiasis [ 176 , 177 , 186 ] and vaginal candidiasis [ 178 , 179 , 180 , 181 , 182 ]. In the former, chitosan was incorporated into PNs, resulting in inhibition of the biofilm adhesion and formation of Candida .…”
Section: Polymeric Nanoparticlesmentioning
confidence: 99%
“…In addition, due to the short time protocol of the C. albicans assays [23], the nanoTSC was only evaluated in vivo in a murine model of VVC. This model is well established in our research group, which is being used to test different nanoencapsulated compounds [22,45]. To ensure the infection, estradiol valerate was weekly administered in the animals [30].…”
Section: Discussionmentioning
confidence: 99%