Micro- and macrostructural characterization of polyvinylpirrolidone rotary-spun fibers

Abstract

The application of high-speed rotary spinning can offer a useful mean for either preparation of fibrous intermediate for conventional dosage forms or drug delivery systems. Polyvinylpyrrolidone (PVP) and poly(vinylpyrrolidone-vinylacetate) (PVP VA) micro- and nanofibers of different polymer concentrations and solvent ratios were prepared with a high-speed rotary spinning technique. In order to study the influence of parameters that enable successful fiber production from polymeric viscous solutions, a complex micro- and macrostructural screening method was implemented. The obtained fiber mats were subjected to detailed morphological analysis using scanning electron microscope (SEM), and rheological measurements while the microstructural changes of fiber samples, based on the free volume changes, was analyzed by positron annihilation lifetime spectroscopy (PALS) and compared with their mechanical characteristics. The plasticizing effect of water tracked by ortho-positronium lifetime changes in relation to the mechanical properties of fibers. A concentration range of polyvinylpyrrolidone solutions was defined for the preparation of fibers of optimum fiber morphology and mechanical properties. The method enabled fiber formulation of advantageous functionality-related properties for further formulation of solid dosage forms.

Submicron aerosol filtration performance of centrifugally spun nanofibrous polyvinylpyrrolidone media

“…The system is said to be safe and cost-effective among the other nanofiber production systems [20]. PVP, polycaprolactone (PCL) and polylactic acid (PLA) polymers are successfully spun with the centrifugal spinning system [21–24].…”

Incorporating small molecules or biologics into nanofibers for optimized drug release: A review

“…The incorporation of proteins or peptides into polymeric nanofibres with pH-dependent dissolution properties can prevent drug degradation in certain regions of the intestines. The manufacturing of drugloaded fibres, most commonly through spinning techniques (electrospinning or force spinning), enables the employment of preparation conditions (temperatures and solvents) that will not damage the structure of macromolecules (Sebe et al, 2015a;Sill and von Recum, 2008).…”

Design of the Prototype of Contact Drawing Device for Potential Individual Therapeutic Fiber Formation Purposes

“…The measuring parameters were the accelerating high voltage: 20 kV; working distance: 12 mm. The average diameters of the fibers were determined based on the diameters of 50 different randomly selected individual filaments [8].…”