2017
DOI: 10.1039/c7cc01988b
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Micro- and nano-patterned conductive graphene–PEG hybrid scaffolds for cardiac tissue engineering

Abstract: A lack of electrical conductivity and structural organization in currently available biomaterial scaffolds limits their utility for generating physiologically representative models of functional cardiac tissue. Here we report on the development of scalable, graphene-functionalized topographies with anisotropic electrical conductivity for engineering the structural and functional phenotypes of macroscopic cardiac tissue constructs. Guided by anisotropic electroconductive and topographic cues, the tissue constru… Show more

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Cited by 98 publications
(60 citation statements)
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“…Unlike normal myocardium, fibrotic tissue resulting from myocardial infarction has a dramatically reduced electrical conductivity, which leads to the malfunction of the cardiac muscle [ 56 ]. Multiple conductive biocompatible polymer nanocomposites containing various carbon nanomaterials including CNTs have been studied to date [ 57 , 58 , 59 ]. The high electrical conductivity of CNTs is determined by their electronic structure, characterized by a delocalized electronic band [ 60 ].…”
Section: Discussionmentioning
confidence: 99%
“…Unlike normal myocardium, fibrotic tissue resulting from myocardial infarction has a dramatically reduced electrical conductivity, which leads to the malfunction of the cardiac muscle [ 56 ]. Multiple conductive biocompatible polymer nanocomposites containing various carbon nanomaterials including CNTs have been studied to date [ 57 , 58 , 59 ]. The high electrical conductivity of CNTs is determined by their electronic structure, characterized by a delocalized electronic band [ 60 ].…”
Section: Discussionmentioning
confidence: 99%
“…Finally, PMMA is removed which results in graphene‐functionalized PEG structure. (This panel was prepared with modification of figure from Smith et al, ). CNT, carbon nanotube; PMMA, polymethylmethacrylate…”
Section: Electroconductive Scaffoldsmentioning
confidence: 99%
“…This graphene effect has attributed to its carbon substrate due to interactions with the charged membranes of cardiac cells resulting in an improvement in morphology and function. Hydrophilicity was also suggested as another reason for phenotypic enhancement on these micro‐ and nanopatterned conductive graphene–PEG hybrid scaffolds (Smith et al, ).…”
Section: Electroconductive Scaffoldsmentioning
confidence: 99%
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“…One way to produce cardiac patches with suitable electrical properties is fabrication of composites comprising a nonconductive cytocompatible polymer matrix and conductive reinforcing filler such as carbon nanotubes (CNTs) or carbon nanofibers and gold nanoparticles (Balint, Cassidy, & Cartmell, 2014;Naseri, Diba, Golkar, Boccaccini, & Taylor, 2014;Smith et al, 2017;Stout, Basu, & Webster, 2011). CNTs exhibit excellent physicochemical properties such as high aspect ratio, very low density, small size, excellent thermal properties, strong mechanical resistance, elasticity, and high electrical conductivity.…”
mentioning
confidence: 99%