Micro and Nanofibers

Pourdeyhimi, Behnam; Fedorova, Nataliya; Mazé, Benoît

doi:10.1002/9781119267713.ch10

Cited by 2 publications

(1 citation statement)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Islands-in-the-sea configuration in Figure 3 can be used with a soluble polymer like PLA in the continuous phase (the sea) and an insoluble polymer like PBT as the islands so that after web formation dissolution of the sea will leave behind fibers of the island that are 1 µm or less. Several patents cover the manufacturing of islands-in-the-sea structures (Pourdeyhimi & Sharp, 2011;Pourdeyhimi et al, 2013aPourdeyhimi et al, , 2013b) and a patent on the conformal grafting of islands-in-the-sea nonwoven fabrics was issued to Heller et al (M. Heller et al, 2021). Finally, complex fiber cross sections can also be extruded to increase the surface area of a fiber beyond its nominal diameter.…”

Section: Nonwoven Fabricationmentioning

confidence: 99%

Advances in high‐throughput, high‐capacity nonwoven membranes for chromatography in downstream processing: A review

Lavoie

Fan

Pourdeyhimi

et al. 2023

Biotech & Bioengineering

View full text Add to dashboard Cite

Nonwoven membranes are highly engineered fibrous materials that can be manufactured on a large scale from a wide range of different polymers, and their surfaces can be modified using a large variety of different chemistries and ligands. The fiber diameters, surface areas, pore sizes, total porosities, and thicknesses of the nonwoven mats can be carefully controlled, providing many opportunities for creative approaches for the development of novel membranes with unique properties to meet the needs of the future of downstream processing. Fibrous membranes are already finding use in ultrafiltration, microfiltration, depth filtration, and, more recently, in membrane chromatography for product capture and impurity removal. This article summarizes the various methods of manufacturing nonwoven fabrics, and the many methods available for the modification of the fiber surfaces. It also reviews recent studies focused on the use of nonwoven fabric devices in membrane chromatography and provides some perspectives on the challenges that need to be overcome to increase binding capacities, decrease residence times, and reduce pressure drops so that eventually they can replace resin column chromatography in downstream process operations.

show abstract

Section: Nonwoven Fabricationmentioning

confidence: 99%