Micro–computerized tomography analysis: dynamics of bone augmentation within a titanium cap in rabbit calvarium

Min, Seiko; Sato, Shuichi; Saito, Masakazu; Ebihara, Hajime; Arai, Yoshinori; Ito, Koichi

doi:10.1016/j.tripleo.2008.04.012

Cited by 24 publications

(26 citation statements)

References 13 publications

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“…This system produces high-resolution images, is quick, delivers only a low effective dose of radiation, and can produce clear images of bones in small living animals. Min et al (13) used R_mCT to observe the dynamics of bone augmentation without graft materials in rabbit calvaria. In a previous study (14), we used R_mCT to examine bone augmentation beyond the skeletal envelope in rat calvaria, A comparative study of microfocus CT and histomorphometry in the evaluation of bone augmentation in rat calvarium Go Kochi 1) , Shuichi Sato 2,3) , Hajime Ebihara 2) , Jiro Hirano 2) , Yoshinori Arai 4) and Koichi Ito Original with or without HA.…”

Section: Introductionmentioning

confidence: 99%

A comparative study of microfocus CT and histomorphometry in the evaluation of bone augmentation in rat calvarium

et al. 2010

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Microfocus computed tomography (micro-CT; R_mCT) is a dynamic noninvasive method for measuring bone regeneration. This study evaluated whether R_mCT was equivalent to histomorphometry in assessing bone augmentation. Two plastic caps of graft material with (experiment) or without hydroxyapatite (HA; control) were placed in the exposed calvaria of rats. Images of bone augmentation within the plastic caps were then taken using R_mCT. Histological sections were cut along the same plane as that used for the micro-CT images. Bone regeneration beyond the skeletal envelope occurred at both the experimental and control sites. Bone volume also increased at both sites. In addition, consistent patterns of bone formation were observed in both R_mCT and histological images. R_mCT analysis enables highly quantitative and qualitative measurement of bone augmentation in living animals. (J Oral Sci 52, 203-211, 2010)

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Section: Introductionmentioning

confidence: 99%

A comparative study of microfocus CT and histomorphometry in the evaluation of bone augmentation in rat calvarium

et al. 2010

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“…Although we have investigated the effect of various regenerative factors and biomaterials on GBA in rat calvarium, it can be difficult to measure the amount and height of newly generated bone accurately. [1][2][3] Parathyroid hormone (PTH) is an 84-amino-acid regulator of calcium and phosphate metabolism. The active component consists of 34 amino acids from the N-terminus known as teriparatide.…”

mentioning

confidence: 99%

Effects of Intermittent Administration of Parathyroid Hormone on Bone Augmentation in Rat Calvarium

Tsunori¹,

Sato²,

Hasuike

et al. 2015

Implant Dentistry

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“…The advantages of our model include a lack of spontaneous regeneration and a standardized defect size by the use uniform plastic caps. However, we determined that it is difficult to augment mature bone beyond the skeletal envelope within an occlusive space under various conditions [1][2][3] .…”

Section: Discussionmentioning

confidence: 99%

“…Although we have investigated the effect of various regenerative factors and biomaterials on GBA in rat calvarium, it was difficult to accurately measure the significant amount and height of newly generated bone in every instance [1][2][3] . Platelet-derived growth factor (PDGF) is a potent mitogen and chemotactic factor for mesenchymal cells.…”

Section: Introductionmentioning

confidence: 99%

Effects of Platelet-Derived Growth Factor on Enhanced Bone Augmentation beyond the Skeletal Envelope within a Plastic Cap in the Rat Calvarium

Tsuchiya

Sato

Kigami

et al. 2013

J. Hard Tissue Biology.

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We evaluated the ability of platelet-derived growth factor (PDGF) to promote bone augmentation beyond the skeletal envelope in rat calvarium. The calvaria of 14 rats were exposed and two plastic caps were placed with 0.03% or 0.01% PDGF with a collagen sponge (ACS) or ACS alone in the calvarium. Micro-CT and histological sections were used to obtain amount of bone augmentation within the plastic caps. Bone volume (BV) was calculated using BV-measuring software. The BV and amount of bone augmentation were significantly increased in the PDGF groups compared to the control groups after 4 weeks. However, there was no significant difference between the 0.03% and 0.01% PDGF groups. These results indicate that 0.03% and 0.01% PDGF in ACS enhance bone formation beyond the skeletal envelope in rat calvarium.

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Micro–computerized tomography analysis: dynamics of bone augmentation within a titanium cap in rabbit calvarium

Cited by 24 publications

References 13 publications

A comparative study of microfocus CT and histomorphometry in the evaluation of bone augmentation in rat calvarium

A comparative study of microfocus CT and histomorphometry in the evaluation of bone augmentation in rat calvarium

Effects of Intermittent Administration of Parathyroid Hormone on Bone Augmentation in Rat Calvarium

Effects of Platelet-Derived Growth Factor on Enhanced Bone Augmentation beyond the Skeletal Envelope within a Plastic Cap in the Rat Calvarium

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