Micro/Nano fabricated cantilever based biosensor platform: A review and recent progress

Basu, Aviru Kumar; Basu, Adreeja; Bhattacharya, Shantanu

doi:10.1016/j.enzmictec.2020.109558

Cited by 64 publications

(43 citation statements)

References 75 publications

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“…The elevated levels of prostate specific antigen (PSA) are associated with increased risk of prostate cancer among men. Using antibodies bound to the surface of cantilevers, PSA assay was performed ( Damborska et al, 2017 ; Basu et al, 2020 ).…”

Section: Nanotechnology For Cancer Diagnosismentioning

confidence: 99%

Carbon Based Nanodots in Early Diagnosis of Cancer

et al. 2021

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Detection of cancer at an early stage is one of the principal factors associated with successful treatment outcome. However, current diagnostic methods are not capable of making sensitive and robust cancer diagnosis. Nanotechnology based products exhibit unique physical, optical and electrical properties that can be useful in diagnosis. These nanotech-enabled diagnostic representatives have proved to be generally more capable and consistent; as they selectively accumulated in the tumor site due to their miniscule size. This article rotates around the conventional imaging techniques, the use of carbon based nanodots viz Carbon Quantum Dots (CQDs), Graphene Quantum Dots (GQDs), Nanodiamonds, Fullerene, and Carbon Nanotubes that have been synthesized in recent years, along with the discovery of a wide range of biomarkers to identify cancer at early stage. Early detection of cancer using nanoconstructs is anticipated to be a distinct reality in the coming years.

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Section: Nanotechnology For Cancer Diagnosismentioning

confidence: 99%

Carbon Based Nanodots in Early Diagnosis of Cancer

et al. 2021

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“…The deflection function of each partition ysj(x) is obtained by evaluating (16) in (9) and considering the boundary conditions (17)− (20). Finally, the bending stiffness (EIZ)Sj and deflection of each partition ysj(x) are considered in (6) to estimate the first bending resonant frequency of multilayered resonators with variable cross-sections.…”

Section: A First Bending Resonant Frequencymentioning

confidence: 99%

“…The static deflection ysj(x) of the energy harvester due to its own weight was estimated using (9) and static structural FEM model (Fig. 9a).…”

Section: A First Case: Mems Hybrid Vibration Energy Harvester With Five Fixed Supportsmentioning

confidence: 99%

“…Figure 17a shows the initial static deflection ysj(x) of the harvester with rectangular shape caused by its own weight, which was estimated using (9). Furthermore, Fig.…”

mentioning

confidence: 99%

“…The static deflection ysj(x) (Fig. 18a) caused by the weight of the structure was estimated using (9) while the dynamic deflection yd(x) (Fig. 18b) was estimated using (21) with Qa = 483.60.…”

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confidence: 99%

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Analytical Modeling of the Mechanical Behavior of MEMS/NEMS-Multilayered Resonators With Variable Cross-Sections for Sensors and Energy Harvesters

et al. 2021

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Resonators based on micro and nanoelectromechanical systems (MEMS/NEMS) are used in many applications, including biological and gas sensors, magnetic field sensors, RF switches, accelerometers, piezoelectric micro and nanogenerators, and viscosity sensors. The design of these resonators requires analytical models to predict their mechanical behavior and optimize the sensitivity and resolution. However, most of these models are only applied to resonators with rectangular and uniform cross-sections. In this paper, we present the analytical modeling to determine the first bending resonant frequency, out-of-plane deflections, and normal stresses of MEMS/NEMS-based multilayered resonators with variable cross-sections and multiple fixed supports. The proposed modeling is derived using the well-known Rayleigh and Macaulay methods, as well as the Euler-Bernoulli beam theory. This analytical modeling is applied to four multilayered resonators with different clamped supports and non-uniform cross-sections. The results of our analytical modeling agree well with respect to those of finite element method (FEM) models and experimental data reported in the literature. The proposed analytical modeling can be used to estimate the frequency shift of resonators due to variations of their geometric parameters, number of clamped-supports or mechanical properties of the materials. Furthermore, this modeling can be used to obtain optimal designs of resonators that ensure safe operations and enhanced performance for sensors and energy harvesters in telecommunications, automotive sector, aerospace industry, consumer electronics, non-destructive testing, and navigation.

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Macroporous Polymer Cantilever Resonators for Chemical Sensing Applications

Dąbrowski,

Reculusa,

Thuau

et al. 2023

Adv Materials Technologies

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A novel, cost‐effective strategy for sensing performance enhancement of cantilever‐shaped, mass‐sensitive sensors is presented. The developed strategy relies on the introduction of macroporosity in the recognition unit. The developed sensors are successfully applied in air humidity monitoring as well as in chemical sensing. As mass‐sensitive transducers, polymer microelectromechanical systems (MEMS) in the form of poly(vinylidene fluoride‐trifluoroethylene) [P(VDF‐TrFE)] cantilever resonators are specifically developed. These resonators are modified with a hierarchically structured macroporous poly(2,3′‐bithiophene) film, acting as a sensing layer. The design of the recognition layer takes advantage of the synergistic combination of inverse opal structuring, surface imprinting, and semi‐covalent imprinting of proteins. The resulting cantilever resonators are first successfully tested for air humidity monitoring in the whole relative humidity range (ca.10 – 90%). When the recognition layer is composed of human serum albumin‐imprinted polymer (HSA‐MIP) with a hierarchical structure, it can also be used as a selective chemosensor in a concentration range from 10 pM to 20 µM. The obtained results demonstrate that the macroporosity of the receptor film significantly enhances the sensor performance.

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Micro/Nano fabricated cantilever based biosensor platform: A review and recent progress

Cited by 64 publications

References 75 publications

Carbon Based Nanodots in Early Diagnosis of Cancer

Carbon Based Nanodots in Early Diagnosis of Cancer

Analytical Modeling of the Mechanical Behavior of MEMS/NEMS-Multilayered Resonators With Variable Cross-Sections for Sensors and Energy Harvesters

Macroporous Polymer Cantilever Resonators for Chemical Sensing Applications

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