Micro‐Nanocarriers Based Drug Delivery Technology for Blood‐Brain Barrier Crossing and Brain Tumor Targeting Therapy

Abstract

His research interests include translational studies in the development of new therapies and biomarkers for prognosis and prediction of therapy, and mechanism investigation of treatment resistance in lymphoma. Yinyan Wang is a neurosurgeon and doctoral supervisor at Beijing Tiantan Hospital, and he is a principal investigator for the National Research Center of Neurological Diseases, a principal investigator for China Institute for Brain Research, Beijing. He focused on the individualized precise treatment of gliomas, and he published 72 papers in this field. Lin Feng is an associate professor/doctoral supervisor of Beihang University, "Beijing New Star of Science and Technology." He is a member of the IEEE International Technical Committee on Micro and Nano Robotics, a member of the SCI-indexed journal "Bio-Design and Manufacturing," "Frontiers in Robotics and AI," Science cooperative journal "Cyborg and Bionic Systems." He has published more than 115 academic papers and one textbook on "Introduction to Micro and Nano Robotics." His research interests include precision technology and medical fundamental research on targeted drug delivery field-controlled micro-nanorobots, which is supported by the National Key R&D Program for Intelligent Robotics.

Development and in functional study of a bi-specific sustained release drug-loaded nano-liposomes for hepatocellular carcinoma

“…37 A dual-targeted slow-release delivery microsphere for Glypican-3 (GPC3) and EpCAM not only specifically targets HCC cells, but also serves as a potential MRI contrast agent. 38 In addition, IOE particles containing iron oxide were detectable by dedicated MRI imaging during intra-arterial injection in an animal model of HCC. 39 Dual-specific MRI molecular probes for HCC, results of in vitro studies demonstrated higher targeting efficiency and MRI sensitivity of dual-specific probes for HCC cells compared to single-targeted or non-targeted molecular probes.…”

Research Status of Dendrimer Micelles in Tumor Therapy for Drug Delivery

“…They can improve the water-solubility of drugs, increase targeting ability, [10] and achieve controlled drug release, promoting these anticancer drugs to accumulate in tumor cells and avoiding the toxicity to normal cells. [11][12][13] In addition, nanomedicines are larger than small molecule drugs by ten times, which can minimize kidney filtration, prolong circulation time in the blood, and increase their tumor accumulation. Among the numerous nano-drug delivery systems, dendrimers have received extensive attention due to their dispersibility and abundant surface functional groups which can be modified.…”

Reconfigurable Vortex-like Paramagnetic Nanoparticle Swarm with Upstream Motility and High Body-length Ratio Velocity

“…Untethered micro-nano robots are expected to be the next generation of minimally invasive therapeutic instruments in biomedicine, serving as powerful medical vehicles that can access hard-to-reach areas of the body to perform least-invasive procedures and drug delivery [ 1 – 3 ]. The motions of microrobots in liquid media are at a low Reynolds number condition, and according to the scallop theorem [ 4 , 5 ], movement in such a super-viscous environment requires the breaking of the time-reversal symmetry of the kinetic patterns. Many noncontact microrobot-driven modalities, such as photoelectric driving [ 6 ], ultrasounds [ 7 ], magnetic fields [ 8 ], and their combinations [ 9 ], have been reported.…”