Micro-osteoperforations accelerate orthodontic tooth movement by stimulating periodontal ligament cell cycles

Sugimori, Tadasu; Yamaguchi, Masaru; Shimizu, Mariko; Kikuta, Jun; Hikida, Takuji; Hikida, Momoko; Murakami, Yoshiki; Suemitsu, Maki; Kuyama, Kayo; Kasai, Kazuhiko

doi:10.1016/j.ajodo.2018.01.023

Cited by 32 publications

(33 citation statements)

References 15 publications

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“…Specifically, apoptosis of osteocytes is critical for osteoclast activation and resorption at the compression site of the tooth during OTM 68,69 . Moreover, in a study of OTM with micro-osteoperforations it was shown that the rate of OTM is increased by increased apoptosis and cell proliferation of PDL cells 70 . Therefore, the lower amount of OTM in the absence of ET B could be a result of several different processes, including the anti-apoptotic activity of ET-1 on numerous cells in periodontal tissues.…”

Section: Discussionmentioning

confidence: 99%

The role of endothelin B receptor in bone modelling during orthodontic tooth movement: a study on ETB knockout rats

Disha

Furlani

Drevenšek

et al. 2020

Sci Rep

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the endothelin system has an important role in bone modelling during orthodontic tooth movement (otM); however, little is known about the involvement of endothelin B receptors (et B) in this process. the aim of this study was to evaluate the role of et B in bone modelling during otM using et B knockout rats (et B-KO). Thirty-two male rats were divided into 4 groups (n = 8 per group): the ET B-Ko appliance group, et B-Ko control group, wild type (et B-Wt) appliance group, and et B-Wt control group. the appliance consisted of a super-elastic closed-coil spring placed between the first and second left maxillary molar and the incisors. Tooth movement was measured on days 0 and 35, and maxillary alveolar bone volume, osteoblast, and osteoclast volume were determined histomorphometrically on day 35 of OTM. Next, we determined the serum endothelin 1 (ET-1) level and gene expression levels of the osteoclast activity marker cathepsin K and osteoblast activity markers osteocalcin and dentin matrix acidic phosphoprotein 1 (DMP1) on day 35. The ET B-KO appliance group showed significantly lower osteoblast activity, diminished alveolar bone volume and less otM than the et B-Wt appliance group. our results showed that et B is involved in bone modelling in the late stage of otM. Endothelin 1 (ET-1) plays an important role in the regulation of bone metabolism in physiological as well as in pathophysiological processes 1-4. It has a known role in the maintenance of bone homeostasis and the regulation of osteoblastic function. ET-1 stimulates the proliferation, differentiation and activity of osteoblasts 5,6 and inhibits osteoblast apoptosis, promoting osteoblastic growth 7. ET-1 acts through both endothelin A (ET A) and endothelin B (ET B) receptors. Specifically, it has been shown that the ET-1/ET A axis is an important regulator of osteoblast activity; targeted inactivation of ET A in mature osteoblasts induced lower tibial trabecular bone volume in vivo 8. However, less is known about the role of ET B in osteogenesis. In one study, treatment with the dual ET A and ET B antagonist Macitentan showed decreased vertebral bone mass in mice, potentially from decreased osteoblast activity as well as from the increased osteoclast activity 9. Several studies also indicate the involvement of endothelins during orthodontic tooth movement (OTM) 10-12. Orthodontic movement is a consequence of applying a force to the teeth. It is a mechanism that involves the biomechanical adaptation of the alveolar process and supporting periodontium. Alterations in the vascularity within the periodontal ligament (PDL), the connective tissue that connects a tooth to its surrounding alveolar bone, may trigger responses at the cellular level, such as alveolar bone modelling 13,14. During OTM areas of pressure and tension are formed in the PDL. At pressure areas, which appear in the direction of the application of force,

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Section: Discussionmentioning

confidence: 99%

The role of endothelin B receptor in bone modelling during orthodontic tooth movement: a study on ETB knockout rats

Disha

Furlani

Drevenšek

et al. 2020

Sci Rep

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“…The average rate of tooth movement by conventional orthodontics is estimated to be around 0.8 to 1.2 mm/month when continued forces are being applied. 9 The rate of tooth movement depends on the amount of bone turnover. Thus, the osteoclastic activity occurs at the site of periodontal ligament compression.…”

Section: Biologic Explanation Of Tooth Movement In Orthodonticsmentioning

confidence: 99%

“…The aseptic inflammatory response to the MOPs can vary with regards to the number of perforations administered in addition to their depth as well. 40 Various other tools have been used to place perforations as apparent in the literature, 9,29,35,36 for example, mini-implant facilitated perforations and round burs. A disposable device was explicitly designed by PROPEL Orthodontics (Ossining, NY) to deliver perforations.…”

Section: Micro-osteoperforations: Literature Searchmentioning

confidence: 99%

“…Multiple MOP procedures were performed in various studies to achieve this continued effect of cytokine release after giving MOPs, which showed a constant influence for a month on average. 3,9,17,31 Cramer et al 3 in their split-mouth animal study, however, demonstrated the application of eight MOPs at a depth of 7 mm on seven mature male beagle dogs in the jaw side randomly selected through computerized random number generation for the allocation of experimental and control sides. Contrary to the significant results in many studies, 14,17,28,29 there was not an increase in tooth movement rates due to MOPs.…”

Section: Micro-osteoperforations: Literature Searchmentioning

confidence: 99%

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Micro-osteoperforations and Its Effect on the Rate of Tooth Movement: A Systematic Review

Al‐Khalifa

Baeshen

2020

Eur J Dent

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AbstractProlonged orthodontic treatments have inconvenienced patients and clinicians alike. Surgically assisted techniques for accelerating orthodontic tooth movement have shown promising results in the literature over the years. The minimally invasive nature of micro-osteoperforations (MOPs), however, for enhanced orthodontic tooth movement has recently gained momentum, with many clinical trials conducted on both animals and humans. An electronic search was performed to extract papers using PubMed, Google Scholar, Scopus, and Web of Science. The keywords that were used included “MOP,” “accelerating tooth movement,” “orthodontic tooth movement,” and “regional acceleratory phenomenon.” The studies that met our inclusion criteria were extracted and evaluated in this review. MOPs have been proven time and again, in animal and human studies alike, to increase the rate of orthodontic tooth movement. The application of perforations to cortical bone present in the pathway of teeth, which are specifically to be moved creates transient osteopenia. This reduces the density of the cortical bone, hence speeding up the rate of orthodontic tooth movement. Many techniques have been implemented and perfected to enhance orthodontic tooth movement and shorten the treatment time in the literature. MOPs have proven to be a universally applied, nontechnical, repeatable, and minimally invasive method of accelerating tooth movement, with extremely minimal consequences.

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“…This is a small sample from which to have a conclusion that allows some kind of external validity. Other authors are experimenting with an average of 40 rats, for example, Gudhimella et al 2 using 90 rats and Sugimori et al 3 in 2018 using 50 rats.…”

mentioning

confidence: 99%

Importance of using platelet-rich plasma

Urbina¹

2019

American Journal of Orthodontics and Dentofacial Orthopedics

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Micro-osteoperforations accelerate orthodontic tooth movement by stimulating periodontal ligament cell cycles

Cited by 32 publications

References 15 publications

The role of endothelin B receptor in bone modelling during orthodontic tooth movement: a study on ETB knockout rats

The role of endothelin B receptor in bone modelling during orthodontic tooth movement: a study on ETB knockout rats

Micro-osteoperforations and Its Effect on the Rate of Tooth Movement: A Systematic Review

Importance of using platelet-rich plasma

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