Micro ribonucleic acid <scp>(RNA)</scp>‐101 inhibits cell proliferation and invasion of lung cancer by regulating cyclooxygenase‐2

Lv, Peng; Zhang, Peng; Li, Xin; Chen, Yuan

doi:10.1111/1759-7714.12283

Cited by 23 publications

(16 citation statements)

References 33 publications

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“…MicroRNAs have been implicated in cancer and play critical roles in cancer initiation and progression in cell proliferation, apoptosis, differentiation, invasion and metastasis [35][36][37] . Increasing evidence demonstrates that microRNAs are potential biomarkers or therapeutic targets in tumors.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-132 suppresses cell proliferation in human breast cancer by directly targeting FOXA1

Wang

Ren²,

Ren

et al. 2017

Acta Pharmacol Sin

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Dysregulation of microRNAs (miRNAs) has been implicated in cancer. Recently, miR-132 has been reported to be downregulated in the tissues of patients with breast cancer. In this study, we investigated the functional role of miR-132 and its direct target FOXA1 in breast cancer cells. In 30 human breast cancer tissues, FOXA1 was significantly overexpressed and negatively correlated with miR-132 expression. A bioinformatics analysis suggested that FOXA1 was a potential target of miR-132. Furthermore, dual luciferase reporter assays revealed that miR-132 dose-dependently inhibited the luciferase activity of the wt 3'UTR of FOXA1 rather than the mut 3'UTR of FOXA1 in human MDA-MB-468 and SK-BR3 breast cancer cells. Moreover, ectopic miR-132 expression significantly inhibited FOXA1 protein expression, whereas miR-132 knockdown promoted FOXA1 expression in the breast cancer cells. Ectopic miR-132 expression also suppressed proliferation of the breast cancer cells, whereas miR-132 knockdown promoted proliferation of the breast cancer cells, which was reversed by knockdown of FOXA1 expression. We conclude that MiR-132 suppresses proliferation of breast cancer cells at least partially though inhibition of FOXA1. These results suggest that miR-132 and FOXA1 may be potential biomarkers or therapeutic targets in breast cancer.

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Section: Discussionmentioning

confidence: 99%

MicroRNA-132 suppresses cell proliferation in human breast cancer by directly targeting FOXA1

Wang

Ren²,

Ren

et al. 2017

Acta Pharmacol Sin

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“…Dysregulation of microRNAs has commonly been observed in various cancer types. MicroRNAs play important roles in cancer development and progression by suppressing the expressing of genes involved in cell proliferation, apoptosis, differentiation, invasion and metastasis [20][21][22] .…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-4458 suppresses the proliferation of human lung cancer cells in vitro by directly targeting Lin28B

Liu

et al. 2017

Acta Pharmacol Sin

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Previous studies have shown that the expression of microRNA-4458 (miR-4458) is dysregulated in hepatocellular carcinoma and colon cancer. In this study, we investigated the direct target of miR-4458 and its biological functions in human lung cancer cells. By using the database TargetScan, we identified Lin28B, an oncogene, as a direct target gene of miR-4458. In dual-luciferase reporter assay, we found that miR-4458 mimics dose-dependently inhibited the luciferase activity of the wild-type 3'UTR of Lin28B in human lung cancer A549 and NCI-H1299 cell lines without affecting its mutant forms, whereas anti-miR-4458, an inhibitor of miR-4458, dose-dependently promoted the luciferase activity of the wild-type 3'UTR of Lin28B in A549 and NCI-H1299 cell lines without affecting its mutant forms. Overexpression of miR-4458 significantly decreased the protein levels of Lin28B in the cells, and inhibited the cell growth and colony formation. Conversely, knockdown of miR-4458 with anti-miR-4458 significantly increased the protein levels of Lin28B, and promoted the cell proliferation, which could be reverted by knockdown of Lin28B expression. In addition, we detected the expression of Lin28B using RT-PCR in 40 human lung cancer tissues and matched peritumoral tissues, and found that Lin28B was overexpressed in lung cancer tissues and negatively correlated with miR-4458 expression (r=-0.694, P<0.05). We conclude that miR-4458 is a tumor suppressor, and Lin28B is the direct target of miR-4458. These results suggest the modulation of miR-4458/Lin28B expression offers a potential therapeutic strategy for lung cancer.

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“…Correlation between expression of miR-22 and ACLY in clinical NSCLC specimens needs further investigation. miR-101 suppresses the proliferation, migration and apoptosis resistance in A549 cells (107). Expression of miR-101 in A549 cells inhibits tumor growth following their subcutaneous implantation into severe combined immunodefiecient (SCID) mice as well as lung metastases following their tail vein injection, as revealed by in vivo luciferase imaging.…”

Section: Mirs Inhibiting Lung Cancer Metastasis Identified In Spontanmentioning

confidence: 99%

MicroRNAs as Potential Targets for Therapeutic Intervention With Metastasis of Non-small Cell Lung Cancer

Weidle

Birzele

Nopora

2019

Cancer Genomics Proteomics

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The death toll of non-small cell lung cancer (NSCLC) patients is primarily due to metastases, which are poorly amenable to therapeutic intervention. In this review we focus on miRs associated with metastasis of NSCLC as potential new targets for anti-metastatic therapy. We discuss miRs validated as therapeutic targets by in vitro data, identification of target(s) and pathway(s) and in vivo efficacy data in at least one clinically-relevant metastasis-related model. A few of the discussed miRs correlate with the clinical status of NSCLC patients. Using miRs as therapeutic agents has the advantage that targeting a single miR can potentially interfere with several metastatic pathways. Depending on their mode of action, the corresponding miRs can be up-or downregulated compared to normal matching tissues. Here, we describe therapeutic approaches for reconstitution therapy and miR inhibition, general principles of anti-metastatic therapy as well as current technical pitfalls.

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Micro ribonucleic acid (RNA)‐101 inhibits cell proliferation and invasion of lung cancer by regulating cyclooxygenase‐2

Cited by 23 publications

References 33 publications

MicroRNA-132 suppresses cell proliferation in human breast cancer by directly targeting FOXA1

MicroRNA-132 suppresses cell proliferation in human breast cancer by directly targeting FOXA1

MicroRNA-4458 suppresses the proliferation of human lung cancer cells in vitro by directly targeting Lin28B

MicroRNAs as Potential Targets for Therapeutic Intervention With Metastasis of Non-small Cell Lung Cancer

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