Micro RNA-19a suppresses IL-10 in peripheral B cells from patients with atherosclerosis

Ren, Zhong; Liu, Ning; Zhao, Kun

doi:10.1016/j.cyto.2016.07.019

Cited by 20 publications

(19 citation statements)

References 22 publications

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“…T regula tory cells are the main source of IL 10 [10], hence, due to our results, it appears that down regulation of IL 10 may be related to the decreased umber and functions of T regulatory cells in the patients. Additionally, the roles played by micro RNA (miR) 19a on the down regula tion of IL 10 has been reported by and colleagues [12]. Mir 19a is a main molecule to induce vascular inflam mation and foam cell generation in the atherosclerosis [13].…”

Section: Discussionmentioning

confidence: 94%

Il-10 Is Down-Regulated in the Cardiovascular Diseases Suspected Patients, Independent of Angiography

Razavi

Ahmadi-Roknabadi

Safarian

et al. 2019

Probl Radiac Med Radiobiol

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Інтерлейкін 10 (ІЛ 10) та інтерферон гамма (ІФН γ) є важливими, відповідно, проти та прозапальними ци токінами, які можуть брати участь у патогенезі серцево судинних захворювань. Крім того, фактори навколиш нього середовища-такі, як рентгенівське випромінювання-здатні модулювати експресію цитокінів. Через те, що рентгенівське випромінювання використовується при ангіографії, ця процедура, можливо, змінює експресію цитокінів. Мета. Оцінити рівні ІЛ 10 та ІФН γ сироватки крові у пацієнтів із серцево судинними захворюваннями (у яких наявний або ж відсутній стеноз судин) порівняно зі здоровими контролями, а також ефекти ангіографії щодо вмісту цитокінів у сироватці крові. Матеріали та методи. Дослідження було проведено серед 80 учасників-по 20 випадків у кожній групі (здо рові контролі та особи із серцево судинними захворюваннями без стенозу судин, із стенозом 1 судини та сте нозом більш ніж 1 судини) для оцінки рівнів ІЛ 10 та ІФН γ у сироватці крові за допомогою методу імунофер ментного аналізу. Для з'ясування впливу процедури ангіографії на рівень ІЛ 10 та ІФН γ у сироватці крові, вміст обох цитокінів також порівнювали у групах 2, 3 та 4 до та після ангіографічного дослідження. Результати. Рівень ІЛ 10, але не ІФН γ, у сироватці крові здорових осіб групи контролю був більшим, ніж у всіх пацієнтів із серцево судинними захворюваннями. Рівень ІЛ 10 та ІФН γ у сироватці крові не змінювався після ангіографії, а також не відрізнявся у курців та осіб, які не курять, так само як і у споживачів опію та осіб, які опій не вживають. Висновки. Завдяки результатам можна зробити висновок, що ІЛ 10 можна ймовірно вважати інгібітором сер цево судинних захворювань, незалежно від тривалості ангіографії та рентгенографії, в той час як ІФН γ не про являє ефектів у іранських пацієнтів, які страждають на серцево судинні захворювання. Ключові слова: ангіографія, рентгенографія, ІЛ 10, ІФН γ.

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Section: Discussionmentioning

confidence: 94%

Il-10 Is Down-Regulated in the Cardiovascular Diseases Suspected Patients, Independent of Angiography

Razavi

Ahmadi-Roknabadi

Safarian

et al. 2019

Probl Radiac Med Radiobiol

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“…Further studies demonstrated that miR-19b-1 is one of miRNAs in miR-17-92 cluster responsible for promoting T H 17-mediated inflammation by targetedly repressing PTEN expression, thereby augmenting the PI3K-AKT-mTOR axis essential for proper T H 17 differentiation [22]. Increasing evidence that miR-19 family (i.e., miR-19a and miR-19b-1) has been highly involved in immunity [4] and inflammatory diseases, including RA [4,5,11], asthma [6,24,25], atherosclerosis [7,8], diabetic retinopathy [26], nasal polyposis [9], sepsis [10], encephalitis [27] and Crohn's disease [28][29][30][31]. miR-19b-1 positively regulated NF-κB signaling, which is one of the critical promoters of inflammation, while the positive regulation of NF-κB signaling by miR-19b-1 involves the coordinated suppression of negative regulators of NF-κB signaling, including A20/Tnfaip3, Rnf11, Fbxl11/Kdm2a and Zbtb16 [4].…”

Section: Discussionmentioning

confidence: 99%

“…Elevated expression of miR-19a in human airway-infiltrating T cells of patients with asthma, and miR-19a promoted TH2 cytokine production in the airways and amplified inflammatory signaling by direct targeting of the inositol phosphatase PTEN, the signaling inhibitor SOCS1 and the deubiquitinase A20 [24], while miR-19b-1 reduced airway remodeling, airway inflammation and degree of oxidative stress by inhibiting Stat3 signaling through TSLP downregulation in a mouse asthma model [25]. Moreover, the endothelial hypoxia-inducible factor-1α promoted atherosclerosis and monocyte recruitment by upregulating miR-19a [7], while TNF-α or IFN-γ or IL-4 suppressed IL-10 in B cells (from patients with atherosclerosis) via upregulating miR-19a expression [8]. miR-19a negatively interfered with IL-10 expression in peripheral dendritic cells (DCs) of patients with nasal polyposis [19].…”

Section: Discussionmentioning

confidence: 99%

“…When we explored the roles of dysregulated miR-19 in lung cancer, microarray-based gene expression data unexpectedly demonstrated a significant number of inflammatory and immune response genes up-or down-regulated by miR-19, including interferon(IFN)-stimulated genes such as GBP1, IFRD1, IFI35, IFI6 and PSMB9, and complement components, suggesting a strong relationship between miR-19 and inflammation in cancer. On the other hand, there are several lines of evidence that miR-19 family can act as regulators of inflammatory response in some diseases, including rheumatoid arthritis (RA) [4,5], asthma [6], atherosclerosis [7,8], nasal polyposis [9] and sepsis [10]. miR-17-92 was down-regulated in activated fibroblast-like synoviocytes (FLS) isolated from RA patients, and miR-19a and miR-19b-1 regulate Tolllike receptor 2 (TLR2) expression thereby reducing the inflammatory response induced by bacterial lipoprotein (BLP) in FLS and which is characterized by the secretion of IL-6 and Matrix metalloproteinases (MMP-3) [4,11].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

miR-19 regulates the expression of interferon-induced genes and MHC class I genes in human cancer cells

Lin

Chen

et al. 2020

Int. J. Med. Sci.

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MicroRNA -19 (miR-19) is identified as the key oncogenic component of the miR-17-92 cluster. When we explored the functions of the dysregulated miR-19 in lung cancer, microarray-based data unexpectedly demonstrated that some immune and inflammatory response genes (i.e., IL32, IFI6 and IFIT1) were generally down-regulated by miR-19 overexpression in A549 cells, which prompted us to fully investigate whether the miR-19 family (i.e., miR-19a and miR-19b-1) was implicated in regulating the expression of immune and inflammatory response genes in cancer cells. In the present study, we observed that miR-19a or miR-19b-1 overexpression by miRNA mimics in the A549, HCC827 and CNE2 cells significantly downregulated the expression of interferon (IFN)-regulated genes (i.e., IRF7, IFI6, IFIT1, IFITM1, IFI27 and IFI44L). Furthermore, the ectopic miR-19a or miR-19b-1 expression in the A549, HCC827, CNE2 and HONE1 cells led to a general downward trend in the expression profile of major histocompatibility complex (MHC) class I genes (such as HLA-B, HLA-E, HLA-F or HLA-G); conversely, miR-19a or miR-19b-1 inhibition by the miRNA inhibitor upregulated the aforementioned MHC Class I gene expression, suggesting that miR-19a or miR-19b-1 negatively modulates MHC Class I gene expression. The miR-19a or miR-19b-1 mimics reduced the expression of interleukin (IL)-related genes (i.e., IL1B, IL11RA and IL6) in the A549, HCC827, CNE2 or HONE1 cells. The ectopic expression of miR-19a or miR-19b-1 downregulated IL32 expression in the A549 and HCC827 cells and upregulated IL32 expression in CNE2 and HONE1 cells. In addition, enforced miR-19a or miR-19b-1 expression suppressed IL-6 production by lung cancer and nasopharyngeal carcinoma (NPC) cells. Taken together, these findings demonstrate, for the first time, that miR-19 can modulate the expression of IFN-induced genes and MHC class I genes in human cancer cells, suggesting a novel role of miR-19 in linking inflammation and cancer, which remains to be fully characterized.

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“…Like miR‐19b, miR‐19a is a pro‐inflammatory marker involved in macrophage‐derived foam cell formation. However, it acts via direct suppression of the HMG‐Box transcription factor 1 (HBP‐1) and indirect suppression of IL‐10 . Several studies found that lipid metabolism biomarkers miR‐486, miR‐92a and miR‐126 present in CAD patients and are associated mainly with HDL .…”

Section: Clinical Studies Of Mirnas In Atherosclerosismentioning

confidence: 99%

Diagnostic and theranostic microRNAs in the pathogenesis of atherosclerosis

Shoeibi

2019

Acta Physiologica

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MicroRNAs (miRNAs) are a group of small single strand and noncoding RNAs that regulate several physiological and molecular signalling pathways. Alterations of miRNA expression profiles may be involved with pathophysiological processes underlying the development of atherosclerosis and cardiovascular diseases, including changes in the functions of the endothelial cells and vascular smooth muscle cells, such as cell proliferation, migration and inflammation, which are involved in angiogenesis, macrophage function and foam cell formation. Thus, miRNAs can be considered to have a crucial role in the progression, modulation and regulation of every stage of atherosclerosis. Such potential biomarkers will enable us to predict therapeutic response and prognosis of cardiovascular diseases and adopt effective preclinical and clinical treatment strategies. In the present review article, the current data regarding the role of miRNAs in atherosclerosis were summarized and the potential miRNAs as prognostic, diagnostic and theranostic biomarkers in preclinical and clinical studies were further discussed. The highlights of this review are expected to present opportunities for future research of clinical therapeutic approaches in vascular diseases resulting from atherosclerosis with an emphasis on miRNAs. K E Y W O R D Satherosclerosis, diagnosis, miRNA, prognosis, therapeutic approaches 2 of 24 | SHOEIBI Because miRNAs have a relatively high stability under the physiological conditions of mammals, they can be used as prognostic and diagnostic markers for diseases, such as atherosclerosis. This review aims to describe and summarize miRNA expression studies in model animal experiments and clinical practices related to atherosclerosis. The expressed pattern of miRNAs contributing to atherosclerosis at different stages of the atherosclerotic process in comparison with healthy arteries is also discussed.

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Micro RNA-19a suppresses IL-10 in peripheral B cells from patients with atherosclerosis

Cited by 20 publications

References 22 publications

Il-10 Is Down-Regulated in the Cardiovascular Diseases Suspected Patients, Independent of Angiography

Il-10 Is Down-Regulated in the Cardiovascular Diseases Suspected Patients, Independent of Angiography

miR-19 regulates the expression of interferon-induced genes and MHC class I genes in human cancer cells

Diagnostic and theranostic microRNAs in the pathogenesis of atherosclerosis

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