Micro-structured P–N junction surfaces: large-scale preparation, antifouling properties, and a synergistic antibacterial mechanism

Ni, Mengfei; Li, Wenwen; Yuan, Bing; Zou, Shuai; Cheng, Wei; Yang, Kai; Su, Jiandong; Sun, Bingwei; Su, Xiaodong

doi:10.1039/d2tb02258c

Cited by 4 publications

(2 citation statements)

References 45 publications

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“…In addition, MNs can be administered with less discomfort than conventional injections, increasing patient compliance, fastening puncture area healing, and avoiding the first-pass metabolism of orally administered drugs [ 44 , 45 , 46 ]. Some MNs are prepared using specially designed materials, such as PN-Si, chitosan metal nanocomposites, etc., which are naturally antimicrobial, and thus, MNs themselves can be used as therapeutic agents to promote tissue repair [ 47 , 48 , 49 ]. In addition, MN-based biosensors effectively capture dermal interstitial fluid (ISF) [ 50 ] and have been shown in preclinical experiments to be effective in monitoring blood glucose [ 51 ], electrolyte levels [ 52 ], Ph level [ 53 ], and biomarkers such as epidermal growth factor receptor 2 [ 54 ], carcinoembryonic antigen [ 55 ], cystatin C, etc.…”

Section: Types and Materials Of Microneedlesmentioning

confidence: 99%

Research Progress of Extracellular Vesicles-Loaded Microneedle Technology

Wang,

Cheng,

2024

Pharmaceutics

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Microneedles (MNs), renowned for their painless and minimally invasive qualities, exhibit significant potential for facilitating effective drug delivery, vaccination, and targeted sample extraction. Extracellular vesicles (EVs), serving as cargo for MNs, are naturally occurring nanovesicles secreted by cells and characterized by novel biomarkers, low immunogenicity, and cell-source-specific traits. MNs prove instrumental in extracting EVs from the sample fluid, thereby facilitating a promising diagnostic and prognostic tool. To harness the therapeutic potential of EVs in tissue repair, MNs with sustained delivery of EVs leverage micron-sized channels to enhance targeted site concentration, demonstrating efficacy in treating various diseases, such as Achillea tendinopathy, hair loss, spinal cord injury, and diabetic ulcers. EV-loaded MNs emerge as a promising platform for repair applications of skin, cardiac, tendon, hair, and spinal cord tissues. This review commences with an overview of MNs, subsequently delving into the role of EVs as cargo for MNs. The paper then synthesizes the latest advancements in the use of EV-loaded MNs for tissue regenerative repair, extending to research progress in extracting EVs from MNs for disease diagnosis and prognostic evaluations. It aims to offer valuable insights and forecast future research trajectories with the hope of inspiring innovative ideas among researchers in this field.

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Section: Types and Materials Of Microneedlesmentioning

confidence: 99%

Research Progress of Extracellular Vesicles-Loaded Microneedle Technology

Wang,

Cheng,

2024

Pharmaceutics

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“…Antibacterial surfaces are essential to reduce infections and illness in a wide variety of applications such as medical devices, sutures, contact lens cases, dental implants, and catheters [1][2][3][4][5][6][7][8][9][10][11] as well as everyday household items such as kitchen and bathroom surfaces, appliances, consumer products, health club equipment, and food packaging [12][13][14]. Surfaces that are antiviral are also of much interest for these applications [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Black silicon spacing effect on bactericidal efficacy against gram-positive bacteria

Kayes,

Zarei,

Feng

et al. 2023

Nanotechnology

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The morphology of regular and uniform arrays of black silicon structures were evaluated for bactericidal efficacy against gram-positive, nonmotile \textit{Staphylococcus~epidermidis} (\textit{S.~epidermidis}). In this study, uniform and regular arrays of black silicon structures were fabricated using nanosphere lithography. A systematic evaluation of nanomorphology effects on bacterial killing were studied with 300 to 1400 nm pitch silicon nanostructureson spherical cocci of about 500 to 1000 nm in diameter. Our results show that morphology factors such as height and roughness do not directly determine bactericidal efficacy. Instead, the spacing between nanostructures is key in determining how bacteria are stretched and lysed. Smaller pitch nanostructures are better for killing bacteria and an $82 \pm 3$ $\%$ enhancement in the killing was observed for 300 nm pitch nanoneedles surface compared to the flat control substrates.

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A solid strategy to realize efficient antibacterial activity on the shade surface of bulk silicon under natural or indoor lighting

Ni,

Jiang,

Cheng

et al. 2024

Chemical Engineering Journal

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Micro-structured P–N junction surfaces: large-scale preparation, antifouling properties, and a synergistic antibacterial mechanism

Abstract: Constructing an antifouling surface cost-effectively is vitally important in many scenes. Herein, a class of silicon substrates with micro-pyramid structure and p-n junction were fabricated following the simple industrial processing...

Cited by 4 publications

References 45 publications

Research Progress of Extracellular Vesicles-Loaded Microneedle Technology

Research Progress of Extracellular Vesicles-Loaded Microneedle Technology

Black silicon spacing effect on bactericidal efficacy against gram-positive bacteria

A solid strategy to realize efficient antibacterial activity on the shade surface of bulk silicon under natural or indoor lighting

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