Microalbuminuria evaluated as a biomarker in patients with septic shock

Grion, Carvalho; Cardoso, Lucienne Tibery Queiroz; Carrilho, Cláudia Maria Dantas de Maio; Altafin, Juliana Am; Barros, Sílvia Berlanga de Moraes; Carvalho, Leonardo de; Festti, Josiane; Mansano, Fpn; Okamoto, Thábata Yaedu; Uehara, Kawana Megumi; Dias, Jéssica Christiane Yoshihara; Silva, Grazielle C.

doi:10.1186/cc8262

Cited by 1 publication

(3 citation statements)

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“…[6] In a study done by Grion et al, median ACR at 3rd day of admission was 61.8 among survivors and median ACR at 3rd of admission was 137.02 among non survivors, indicating its prognostic significance. [23] In a study done by Bhavita et al, median ACR2 at 24 hours of admission was 46 among survivors and median ACR2 at 24 hours of admission was 164.5, p value was <0.0001 which was statistically significant, indicating its prognostic significance. [24] In a study conducted by Mackinnon et al, concluded ACR measured 6hour after post admission to ICU showed a significant difference (p =0.01) among survivors & non survivors, permitting identification of patients at Increased risk of development of organ failure and death.…”

Section: Methodsmentioning

confidence: 97%

“…[22] Grion et al too showed males as majority (63.3%). [23] Bhavita et al majority of the patients was males (53%). [24] In our study, Microalbuminuria occurred in 68% of the patient .Thoreveska et al showed occurrence of microalbuminuria in 69% patient.…”

Section: Methodsmentioning

confidence: 99%

“…[22] In a study done by Grion et al mortality rate was 71.4%. [23] In a study conducted by a Bhavita et al mortality rate was 18%. [24] In our study median ACR1 was 66.42 among survivors and ACR 1 among non-survivors was 161.46, p value was <0.001 which was statistically significant.…”

Section: Methodsmentioning

confidence: 99%

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Microalbuminuria as a Marker of Sepsis - A Prospective Study in a Tertiary Care Hospital

Agarwal¹,

Haria²

2017

Ann. Int. Med. Den.Res.

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Background: Diffused endothelial dysfunction in sepsis leads to an increase in systemic capillary permeability, the renal component manifesting as microalbuminuria. The degree of microalbuminuria correlates with the severity of the acute insult, the quantification of which may serve to predict sepsis and mortality in critically ill patients. Aim: To study the trend of microalbuminuria in sepsis patient, to evaluate microalbuminuria as novel biomarker of sepsis, To evaluate the capability of microalbuminuria for the prediction of ICU mortality. Methods: After exclusions, between November 2014 to May 2015, 50 consecutive adult patients were found eligible. Urine spot samples was collected at the time of ICU admission for Albumin Creatinine Ratio 1 and Albumin Creatinine Ratio 2 at 24hrs of ICU admission and Albumin creatinine Ratio 3. Results: Total of 50 patients were included into the study. The study included 56% of the patients as males and 44% as females. Out of 50 patients 78% of the patients had microalbuminuria, 66% of the patient were culture positive, out of which 79.49% of the patient had microalbuminuria. Majority of the patient (87.18%) with microalbuminuria require mechanical ventilation and the ICU stay was prolonged in survivor patients. Mortality rate was 61.54%. Microalbuminuria levels at 24 hours of admission among survivors and non survivors indicates its prognostic significance in ICU mortality. Conclusion: Microalbuminuria is a reliable marker of sepsis, At 48 hours of admission, increased levels of microalbuminuria compared to microalbuminuria levels at admission and 24 hour, indicates its prognostic significance among survivors and non survivors in critically ill patients.

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Section: Methodsmentioning

confidence: 97%

Section: Methodsmentioning

confidence: 99%