Microalbuminuria Is the Earliest Predictive Marker for Microvascular Complications and Cardiovascular Risk in Patients With Diabetes, a Randomized Study Conducted in Rural Population of Bankura District, West Bengal.

Abstract

Diabetic nephropathy is one of the major microvascular complications in both type1 and type2 diabetes. It is also a risk factor for development of macrovascular complications including atherosclerosis, myocardial infarction, cerebrovascular accident (CVA) and peripheral vascular diseases. A randomized study conducted on diabetic (n=40) with an age group between 40 to 70 years, where non-diabetic (n=35) was control. Fischer's unpaired "ttest" was the analytical tool for the study and which shows 24 hours urine microalbumin and creatinine as well as microalbumin/creatinine ratio in diabetic was significantly altered as compared with non-diabetic control, where the p-value is < 0.001.Altered lipid metabolism in diabetic was evaluated by measuring total cholesterol, triglyceride, LDL-C. Statistical analysis showed remarkable elevation of all above and the p-value was <0.001,and was significant. The study revealed some deleterious microvascular changes in diabetes and imposes cardiovascular risk.