Microalgae as a source of high-value bioactive compounds

Bule, Mohammed Hussen; Ahmed, Ishtiaq; Maqbool, Faheem; Bilal, Muhammad; Iqbal, Hafiz M.N.

doi:10.2741/s509

Cited by 80 publications

(18 citation statements)

References 103 publications

(147 reference statements)

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“…However, algae are heterogeneous from an evolutionary point of view [ 39 ]. Coastal area algae are mostly macroalgae and classified into three types: Chlorophyred (green), Rhodophyceae (red), and Phaeophycea (brown) algae [ 34 , 35 , 37 , 40 , 41 ]. Microalgae are found as phytoplankton throughout the oceanic ecosystem [ 40 ].…”

Section: Marine Algae: Sources Production Strategies and Appliedmentioning

confidence: 99%

“…Algae have become a sustainable resource due to the growing demand for bioprocessing to obtain environmentally friendly products [ 49 ]. Recently, bioactive compounds from algae [ 37 , 48 ], have become important and are being utilized in various environment-related applications like biofuel production, CO 2 sequestration, wastewater treatment, oxygen discharge to the environment, and reducing the effects of greenhouse gases [ 40 , 50 ].…”

Section: Marine Algae: Sources Production Strategies and Appliedmentioning

confidence: 99%

“…marine algae, offer several advantages such as (1) diverse multifunctional groups on their surface, (2) relatively small and uniform distribution of binding sites on the surface, (3) requires minimal preparatory steps, (4) no or less consumption of harsh chemicals, (5) naturally renewable, recyclable, and easily available all year round, (6) excellent retention capacity, and so on. Based on the literature, the utilization of marine algae as biosorbents has been successfully tested for several biotechnological and industrial applications including the removal of various potentially toxic elements [ 15 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

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Biosorption: An Interplay between Marine Algae and Potentially Toxic Elements—A Review

et al. 2018

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In recent decades, environmental pollution has emerged as a core issue, around the globe, rendering it of fundamental concern to eco-toxicologists, environmental biologists, eco-chemists, pathologists, and researchers from other fields. The dissolution of polluting agents is a leading cause of environmental pollution of all key spheres including the hydrosphere, lithosphere, and biosphere, among others. The widespread occurrence of various pollutants including toxic heavy metals and other emerging hazardous contaminants is a serious concern. With increasing scientific knowledge, socioeconomic awareness, human health problems, and ecological apprehensions, people are more concerned about adverse health outcomes. Against this background, several removal methods have been proposed and implemented with the aim of addressing environmental pollution and sustainable and eco-friendly development. Among them, the biosorption of pollutants using naturally inspired sources, e.g., marine algae, has considerable advantages. In the past few years, marine algae have been extensively studied due to their natural origin, overall cost-effective ratio, and effectiveness against a broader pollutant range; thus, they are considered a potential alternative to the conventional methods used for environmental decontamination. Herein, an effort has been made to highlight the importance of marine algae as naturally inspired biosorbents and their role in biosorption. Biosorption mechanisms and factors affecting biosorption activities are also discussed in this review. The utilization of marine algae as a biosorbent for the removal of numerous potentially toxic elements has also been reviewed.

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Section: Marine Algae: Sources Production Strategies and Appliedmentioning

confidence: 99%

Section: Marine Algae: Sources Production Strategies and Appliedmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Biosorption: An Interplay between Marine Algae and Potentially Toxic Elements—A Review

et al. 2018

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“…Two exemplary lineages of marine-natural product producers are algae and dinoflagellates. In particular, these marine organisms are well-known for their ability to produce small molecules including toxins, pigments, unique lipids, and a variety of other natural products [47,[53][54][55]. Despite many of the structures of algal and dinoflagellate molecules being known for decades, connecting them to their enzymatic machinery is in its infancy.…”

Section: From Molecules To Gene Clusters In Dinoflagellates and Algaementioning

confidence: 99%

Linking Genes to Molecules in Eukaryotic Sources: An Endeavor to Expand Our Biosynthetic Repertoire

Ganley

Derbyshire

2020

Molecules

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The discovery of natural products continues to interest chemists and biologists for their utility in medicine as well as facilitating our understanding of signaling, pathogenesis, and evolution. Despite an attenuation in the discovery rate of new molecules, the current genomics and transcriptomics revolution has illuminated the untapped biosynthetic potential of many diverse organisms. Today, natural product discovery can be driven by biosynthetic gene cluster (BGC) analysis, which is capable of predicting enzymes that catalyze novel reactions and organisms that synthesize new chemical structures. This approach has been particularly effective in mining bacterial and fungal genomes where it has facilitated the discovery of new molecules, increased the understanding of metabolite assembly, and in some instances uncovered enzymes with intriguing synthetic utility. While relatively less is known about the biosynthetic potential of non-fungal eukaryotes, there is compelling evidence to suggest many encode biosynthetic enzymes that produce molecules with unique bioactivities. In this review, we highlight how the advances in genomics and transcriptomics have aided natural product discovery in sources from eukaryotic lineages. We summarize work that has successfully connected genes to previously identified molecules and how advancing these techniques can lead to genetics-guided discovery of novel chemical structures and reactions distributed throughout the tree of life. Ultimately, we discuss the advantage of increasing the known biosynthetic space to ease access to complex natural and non-natural small molecules.

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“…Moreover, phytoplanktons are being consumed as functional foods and reliable supplementary ingredients in human diet [26,27,29]. Having the richest source of unsaturated fatty acids, antioxidants, proteins, and pigments, microalgae have played a pivotal role in supplying aquatic-based bioactive compounds for consumers [30].…”

Section: Introductionmentioning

confidence: 99%

Effects of Iron-Oxide Nanoparticles (Fe3O4) Released From Synthesized Iron-based Thiourea Catalyst on the Growth, Cell Density, and Pigment Content of Chlorella Vulgaris

Yazdanabdad

Forghaniha

Emtyazjoo

et al. 2021

Preprint

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This study investigated the effects of Fe3O4 nanoparticles released from synthesized Thiourea catalyst to Chlorella vulgaris as an essential primary producer in aquatic systems. A range of Fe3O4 concentrations (0, 10, 100, 250, 500, 750, and 1000 mg L-1) was applied for the exposure test. Biological parameters of C. vulgaris, including cell density, cell viability, and pigment content were assessed. Bioconcentration factor and bioaccumulation were evaluated for contaminated microalgae. Non-carcinogenic risks were then assessed using target hazard quotient (THQ) for potential human consumptions. Findings showed that C. vulgaris cell numbers increased from 0 to 500 mg L-1 of Fe3O4. Chlorophyll a represented a time-dependent response, and greatest values were detected in 250 and 500 mg L-1 Fe3O4 at 4.2 and 4 mg/g, respectively. Chlorophyll b content showed a time-related manner in exposure to Fe3O4 with the highest values recorded at 250 mg L-1 after 96 h. Moreover, bioaccumulation displayed a dose-dependent response as bioaccumulated iron was in the largest amount at 15000 µg/g dw in 1000 mg L-1, whereas the lowest one was in the control group at 1700 µg/g dw. The bioconcentration factor showed a concentration-relevant decrease in all iron treatments and 10 mg L-1 of Fe3O4 represented the greatest BCF at 327.3611. Non-carcinogenic risks illustrated negligible hazard (THQ < 1) in a dose-response pattern and the largest EDI and THQ were calculated in 1000 mg L-1 at 7.4332E-07 (mg kg-1 day-1) and 1.06189E-09, respectively. In essence, iron is an essential trace element for biological aspects in aquatic systems, but in exceeding concentrations could impose toxicity effects in C. vulgaris populations.

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Microalgae as a source of high-value bioactive compounds

Cited by 80 publications

References 103 publications

Biosorption: An Interplay between Marine Algae and Potentially Toxic Elements—A Review

Biosorption: An Interplay between Marine Algae and Potentially Toxic Elements—A Review

Linking Genes to Molecules in Eukaryotic Sources: An Endeavor to Expand Our Biosynthetic Repertoire

Effects of Iron-Oxide Nanoparticles (Fe3O4) Released From Synthesized Iron-based Thiourea Catalyst on the Growth, Cell Density, and Pigment Content of Chlorella Vulgaris

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