Microalgae-based polysaccharides: Insights on production, applications, analysis, and future challenges

Caetano, Patrícia Acosta; Nascimento, Tatiele Casagrande do; Fernandes, A. S.; Nass, Pricila Pinheiro; Vieira, Karem Rodrigues; Maróstica, Mário Roberto; Jacob‐Lopes, Eduardo; Zepka, Leila Queiroz

doi:10.1016/j.bcab.2022.102491

Cited by 17 publications

(6 citation statements)

References 148 publications

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“…Additionally, sulphated polysaccharides and their derivatives minimize drag as well as being hypolipidaemic or hypoglycemic. Aside from that, sulphated polysac-charides and their derivatives also act as hypolipidaemics or hypoglycaemics and dragreducers [140,141]. Probiotic Lactobacillus EPS stimulates both pro-inflammatory (Th1) and anti-inflammatory (Th2, Treg) functions and regulates inflammation by decreasing TNF-α-induced IL-8 production in epithelial Caco-2 cells [142,143].…”

Section: Biological Properties Of Cyanobacterial Eps On Immune/inflam...mentioning

confidence: 99%

Role of Bacteria-Derived Exopolysaccharides in Inflammatory Bowel Disease with a Special Focus on Cyanobacterial Exopolysaccharides

Manoharan,

Natesan,

Billamboz

et al. 2024

Applied Microbiology

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Instances of inflammatory bowel disease (IBD), a chronic inflammatory condition of the gastrointestinal tract, are rapidly increasing in western and newly industrialized countries. Exopolysaccharides (EPSs) are one of the strategies to enhance the gut microbiota and modulate the immune-inflammatory response deregulation in IBD patients. EPSs are produced by commensal bacteria such as Lactobacillus and Bifidobacterium. Additionally, Cyanobacteria species are promising sources of novel EPS and have potential pharmaceutical and therapeutic applications. The presence of uronic acids and sulphate groups in Cyanobacterial EPSs is an important factor that gives EPSs an anionic charge that is not seen in other prokaryotic species. This feature may impact their physico-chemical characteristics and biological properties. Additionally, Cyanobacterial EPSs have a wide range of biotechnological applications that include use as thickeners, stabilizers, and gelling agents in the food and pharmaceutical sectors. The present review focuses on the role of EPSs in IBD, with a special focus on EPSs derived from Cyanobacteria. This review also covers the biological properties of Cyanobacterial EPS in immuno-inflammatory responses and against pathogens as well as its role in biotechnological applications. Overall, Cyanobacterial EPSs have therapeutic potential against IBD due to their anti-inflammatory and immunoregulatory properties that can reduce inflammation and regulate the immune response and restore the gut microbiota of patients.

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Section: Biological Properties Of Cyanobacterial Eps On Immune/inflam...mentioning

confidence: 99%

Role of Bacteria-Derived Exopolysaccharides in Inflammatory Bowel Disease with a Special Focus on Cyanobacterial Exopolysaccharides

Manoharan,

Natesan,

Billamboz

et al. 2024

Applied Microbiology

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“…The total sugar content of microalgae ranges from 5% to 23%, and the relative molecular weight of microalgae is generally medium or high with a range of 10 to 1000kDa [1]. Most of them are composed of different monosaccharides (monosaccharides, disaccharides and oligosaccharides) linked and polymerized carbon chains through glycosidic bonds.…”

Section: Structure and Composition Of Microalgae Polysaccharidementioning

confidence: 99%

Research Progress and Development Strategy of Microalgae Polysaccharides

Zhao,

Bai,

Zhang

et al. 2024

TMBLS

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With the increasingly in-depth marine research, the high-value utilization of seafood has been a research trend, among which the research on microalgae polysaccharides is sufficient. At present, a large number of studies have shown that microalgae polysaccharides have a wide range of biological activities, but their structural analysis is not systematic. Thus, in the past, the research on microalgae polysaccharides mostly focused on a single dimension. In this paper, the structure, composition, analysis method, biological activity and application of microalgae polysaccharides are studied. Meanwhile, the current research status and achievements of microalgae polysaccharides are presented by integrating multiple indexes, and the defects of existing research are analyzed, which provides guiding suggestions for further research and development of microalgae polysaccharides.

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“…Several studies have successfully demonstrated that Spirulina not only has beneficial effects on the development of the nervous system, but it also has a crucial role in the prevention of oxidative stress [8,9], in the treatment of ROS-induced pathologies, and in the development of new treatments for neurodegenerative diseases such as Alzheimer's or Parkinson's [10]. Omid Reza et al, in a randomized, double-blind, controlled trial, demonstrated that the in vivo administration of Spirulina is useful for improving brain function and metabolic pathways in Alzheimer's Disease [11].…”

Section: Of 13mentioning

confidence: 99%

Potential Protective Effects of Spirulina (Spirulina platensis) against In Vitro Toxicity Induced by Heavy Metals (Cadmium, Mercury, and Lead) on SH-SY5Y Neuroblastoma Cells

Mallamaci,

Storelli,

Barbarossa

et al. 2023

IJMS

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Spirulina, a filamentous microalga, is used all over the world as a nutraceutical dietary supplement. Recent studies have focused on examining its chelating activity and antioxidant properties, especially as a candidate for protection against neurotoxicity caused by heavy metals. The MTT test and LDH assay were used to examine the viability of the SH-SY5Y cells for 24, 48, and 72 h, to Cd, Hg, and Pb, individually or in combination with Spirulina, and the effects of necrotic cell death. In comparison to the control group, the viability of SH-SY5Y cells decreased after 24 h of exposure, with Cd being more toxic than Hg and Pb being less lethal. The effects of heavy metal toxicity on cell survival were ranked in order after 72 h under identical experimental circumstances as follows: Hg, Pb, and Cd. The viability of the cells was then tested after being exposed to Spirulina at doses of 5 at 50 (%v/v) for 24, 48, and 72 h, respectively. SH-SY5Y cells that had been treated with mixtures of heavy metals and Spirulina underwent the same assay. Cell viability is considerably increased by using Spirulina treatments at the prescribed periods and doses. Instead, the same procedure, when applied to SH-SY5Y cells, caused the release of LDH, which is consistent with the reduction in cell viability. We demonstrated for the first time, considering all the available data, that Spirulina 5, 25, and 50 (%v/v) enhanced the number of viable SH-SY5Y cells utilized as a model system for brain cells. Overall, the data from the present study provide a first insight into the promising positive role of Spirulina against the potentially toxic effects of metals.

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Microalgae-based polysaccharides: Insights on production, applications, analysis, and future challenges

Cited by 17 publications

References 148 publications

Role of Bacteria-Derived Exopolysaccharides in Inflammatory Bowel Disease with a Special Focus on Cyanobacterial Exopolysaccharides

Role of Bacteria-Derived Exopolysaccharides in Inflammatory Bowel Disease with a Special Focus on Cyanobacterial Exopolysaccharides

Research Progress and Development Strategy of Microalgae Polysaccharides

Potential Protective Effects of Spirulina (Spirulina platensis) against In Vitro Toxicity Induced by Heavy Metals (Cadmium, Mercury, and Lead) on SH-SY5Y Neuroblastoma Cells

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