Microanalysis For Platinum and Magnesium in Body Fluids and Brain Tissue of Mice Treated with Cis-Platinum Using Graphite Filament Plasma Emission Spectroscopy

Belliveau, James F.; Matook, George M.; O’Leary, Gerard; Cummings, Frank J.; Hillstrom, M M; Calabresi, Paul

doi:10.1080/00032718608066247

Cited by 5 publications

(2 citation statements)

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“…The other advantages remain the same but this unit has the same disadvantage as the graphite furnace of NFAAS, due to the high evaporation temperature of 2,700~ Another strategy to perform more reliable determinations of platinum in biological material was to use a DCP-AES apparatus [97 99]. With this technique platinum can also be detected in tissue with a simple dilution and by introducing the sample with a graphite filament [97]. The detection limits of these methods are higher than described for the ICP methods because less sensitive emission lines were chosen (Table 4).…”

Section: (3) 1992mentioning

confidence: 99%

“…A recent study reports an ICP-AES determination of platinum at 214.4 nm combined with the electrothermal vaporization (ETV) unit and background correction via a platinum hollow cathode lamp of a FAAS apparatus (ETV-ICP-AES) [96]. A slightly different technique is direct current plasma atomic emission spectrometry (DCP-AES) in which the argon plasma is generated by an arc-light instead of a coil [97].…”

Section: (3) 1992mentioning

confidence: 99%

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Platinum antitumour agents: A review of (bio)analysis

Hodes

Underberg

Los

et al. 1992

Pharmaceutisch Weekblad Scientific Edition

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This paper summarizes analytical techniques in order to get a clear picture of the ins and outs of the (bio)analysis of platinum-containing compounds. The antitumour agent cisplatin has become an indispensable drug for the cure of a variety of cancer diseases. Since its introduction in the early seventies, about 2,000 related platinum complexes were designed to devoid the dose-limiting nephrotoxicity. Some of them were introduced for clinical trial, such as carboplatin and iproplatin. To investigate the mechanism of action and pharmaco-kinetic behaviour, several interesting assays for total and specific platinum determination in biological matrices have been developed, each with its own possibilities and limitations.

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Section: (3) 1992mentioning

confidence: 99%

Section: (3) 1992mentioning

confidence: 99%