2004
DOI: 10.1182/blood.v104.11.3570.3570
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Microarray Analysis of Peripheral Blood Monocytes in Sickle Cell Anemia Patients with Cerebrovascular Stenosis.

Abstract: Cerebrovascular disease (CVD) of both large and small cerebral vessels occurs in one-third of patients with sickle cell anemia (SCA) by age 20 years. Large vessel stenosis (LVS) occurs in ~10% of patients and is associated with overt stroke and/or (+) transcranial Doppler (TCD). Epistatic genetic modifiers are postulated to account for the significant phenotypic heterogeneity of SCA and likely contribute to CVD. Potential genetic modifers of CVD may be found in pathways for inflammation, adhesion, stress/immun… Show more

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