Microarray assay of circular RNAs reveals cicRNA.7079 as a new anti-apoptotic molecule in spinal cord injury in mice

New Insight of Circular RNAs' Roles in Central Nervous System Post-Traumatic Injury

“…The results further proves that cicRNA_7079 could play an anti-apoptotic role. This study helps elucidate the molecular mechanisms associated with apoptosis in SCI (Yao et al, 2020).…”

“…Yao et al found 1,131 circRNAs with significantly differentially expressed expressions, of which 909 expressions were upregulated and 222 expressions were downregulated. These differentially expressed circRNAs are involved in "mitosis, " "dendrite, " "calcium ion binding, " and "glycosphingolipid biosynthesis and extracellular matrix-receptor" (Yao et al, 2020). In another analysis by Wang and colleagues, the differentially expressed circRNAs participated in "protein phosphorylation, " "cytoplasm, " and "protein binding" (Wang et al, 2020d).…”

“…CircRNA_00180 was significantly decreased 6 h after TBI and its fold change was 5.4 (Jiang et al, 2019). Circ_0008614 was also significantly decreased 3 days after SCI and its fold change was 2.68 (Yao et al, 2020). They share the same gene symbol Col19a1, which is related with encoding nonfibrillar collagen XIX (Su et al, 2010).…”

“…Contusion injury can be caused by regulating different weights and falling heights. The injured spinal cord segments were concentrated in T8-T10 in various studies (Qin et al, 2018;Zhou et al, 2019;Chen et al, 2020;Liu et al, 2020;Wang et al, 2020d;Yao et al, 2020). Two studies explored the expression of circRNAs within a short period after SCI.…”

“…Three days after SCI, the expression of cicRNA_7079 increased significantly in mice. Ying Yao et al found that cicRNA_7079 could act on the cicRNA_7079-mmu-Mir-6953-5p-Lgals3 axis (Yao et al, 2020). Recent studies have found that Gal-3 can modulate the severity of neuroinflammation after SCI by enhancing the activation of the ROS/TXNIP/NLRP3 signaling pathway (Ren et al, 2019).…”