Microarray‐based component‐resolved diagnosis of latex allergy: isolated IgE‐mediated sensitization to latexprofilin Hev b8 may act as confounder

Schuler, Sarah; Schmid‐Grendelmeier, Peter; Harr, Thomas

doi:10.1186/2045-7022-3-11

Cited by 42 publications

(42 citation statements)

References 23 publications

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“…Whether NRL sIgE-sensitized patients have clinically relevant symptoms or not appears to be mirrored in the concentration of sIgE, a correlation also found in other studies [11, 20]. We found significantly higher levels of NRL sIgE in patients with immediate symptoms compared to patients without (see Table 2).…”

Section: Discussionsupporting

confidence: 76%

“…They have a conserved structure across different plant species, resulting in sIgE antibodies reacting to a broad pattern of cross-reactive profilins [16]. The NRL allergen component Hev b 8 is a profilin, and cross-sensitivity between Hev b 8 and timothy grass has been observed [17, 18], resulting in NRL sIgE-sensitized patients who are asymptomatic on exposure to NRL and mono-sensitized to Hev b 8 [2, 8, 17-20]. …”

Section: Introductionmentioning

confidence: 99%

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The Clinical Relevance of Natural Rubber Latex-Specific IgE in Patients Sensitized to Timothy Grass Pollen

Brandi

Poulsen

Garvey

2019

Int Arch Allergy Immunol

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Background: In pollen-allergic patients, cross-reacting allergens including cross-reactive carbohydrate determinants (CCDs) and profilins may result in positive natural rubber latex (NRL)-specific IgE (sIgE) antibody tests but the relationship between this sensitization and clinical NRL type 1 allergy is poorly described. Objective: The aims of this study were to determine the frequency and clinical relevance of NRL sIgE in grass pollen-sensitized individuals and to investigate which NRL allergen components these individuals were sensitized to. Methods: A total of 383 grass-sensitized patients answered questions about NRL allergy symptoms and their stored sera from previous investigations were analyzed for NRL sIgE. Patients with NRL sIgE (n = 32) underwent further investigations comprising medical history, skin prick test with NRL and inhalational allergens, and an additional blood sample. The additional blood samples were analyzed for total IgE and sIgE against NRL, timothy grass, birch, rHev b 1, 3, 5, 6.01, 6.02, 8, 9, 11, rPhl p 12, and MUXF3, which was used as a marker of CCD sensitization. Results: Overall, 9.4% of all grass pollen-sensitized individuals showed IgE sensitization to NRL but only 1.6% had a confirmed type I NRL allergy. CCD and Hev b 8 explained the clinically irrelevant NRL IgE sensitization in 65% of the cases. We found a highly significant correlation between NRL profilin (Hev b 8) sensitization and grass profilin (Phl p 12) sensitization (p < 0.0001). Conclusions: Data from this study support the hypothesis that in patients with grass pollen sensitization, Hev b 8 mono-sensitization has little or no clinical relevance and is caused by cross sensitization from grass profilin (Phl p 12).

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Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

The Clinical Relevance of Natural Rubber Latex-Specific IgE in Patients Sensitized to Timothy Grass Pollen

Brandi

Poulsen

Garvey

2019

Int Arch Allergy Immunol

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“…9,10,11 Es posible que la explicación para entender la reactividad cruzada látex-papaya sea la presencia de los 15 alérgenos del látex del hule que han sido identifi cados y que se clasifi can en panalérgenos y alérgenos constitutivos. 5,12 Los panalérgenos del látex del hule de mayor relevancia clínica son Hev b 1 y Hev b 3 en pacientes con espina bífi da; Hev b 5, Hev b 6 y Hev b 15 en los trabajadores de la salud; y Hev b 2, 4, 7, 8, 11, 12 y 13, asociados con reactividad cruzada y SLF. 5,12,13 El alérgeno Hev b 6.02 es una proteína relacionada con quitinasas, y comparte 50 % de homología con quitinasas de plátano, aguacate y castaña, entre otras.…”

Section: Introductionunclassified

“…5,12 Los panalérgenos del látex del hule de mayor relevancia clínica son Hev b 1 y Hev b 3 en pacientes con espina bífi da; Hev b 5, Hev b 6 y Hev b 15 en los trabajadores de la salud; y Hev b 2, 4, 7, 8, 11, 12 y 13, asociados con reactividad cruzada y SLF. 5,12,13 El alérgeno Hev b 6.02 es una proteína relacionada con quitinasas, y comparte 50 % de homología con quitinasas de plátano, aguacate y castaña, entre otras. El Hev b 11 es una quitinasa clase I, con una posible participación en este síndrome.…”

Section: Introductionunclassified

Síndrome látex-papaya: una asociación poco frecuente

Rojas-Mandujano

González-Juárez

Hernández-Fernández

et al. 2018

RAM

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Background: Latex-fruit syndrome (LFS) is characterized by allergy to latex and plants. Papain, chymopapain, caricaine and class I chitinases are papaya's most allergenic proteins. The similarity between latex hevein epitopes and papaya class I chitinases might explain the latex-papaya syndrome (LPS). Objective: To describe the clinical characteristics of patients with LPS. Methods: Cross-sectional, observational, descriptive study where 11 patients diagnosed with latex allergy by skin prick test and clinically diagnosed with papaya-induced anaphylaxis were included The results were analyzed with descriptive statistics. Results: Out of 11 patients with LPS, 72.7% were females (7 to 46 years), all with a history of papaya-induced anaphylaxis, identifi ed by medical history and medical notes plus latex-positive skin prick tests, with 63.3% exhibiting anaphylaxis in the skin prick tests. Risk factors included multiple surgeries, another allergic disease, and being employed in the fi eld of health; 63.6% were allergic to to other foods, 45.4% to medications, 45.4% had allergic rhinitis and 27.3% had asthma. Conclusions: Hypersensitivity to papaya increases the risk of anaphylaxis in patients with latex allergy and, therefore, mortality. Clinical data is the main diagnostic tool. Education for the management of anaphylaxis with adrenaline self-administration is essential.

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“…The ISAC 112 platform provides a minimally invasive, rapid and efficient means of testing IgE sensitizations to a broad panel of allergen components [3], and has been used as an aid in the diagnosis and risk assessment of allergic patients [20][21][22][23][24][25], to predict allergic symptoms as well as for prescription and monitoring of immunotherapy [26][27][28][29][30], sensitization profiling [31][32][33][34], and for the study of allergic diseases [16,[35][36][37].…”

Section: Introductionmentioning

confidence: 99%