Microarray patches for managing infections at a global scale

Anjani, Qonita Kurnia; Sabri, Akmal Hidayat Bin; Hutton, Aaron J.; Cárcamo-Martínez, Álvaro; Wardoyo, Luki Ahmadi Hari; Mansoor, Alvanov Zpalanzani; Donnelly, Ryan F.

doi:10.1016/j.jconrel.2023.05.038

Cited by 9 publications

(2 citation statements)

References 135 publications

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“…Recent advances in how we deliver antibiotics could also allow more efficient dosing strategies, such as those explored in this study, to become a reality. For example, microarray patches have been developed that allow an easily controllable and accurate way of delivering antibiotics directly into the blood stream or a biofilm [ 61 , 62 ]. Ultimately, there is potential to combine this approach with real-time infection monitoring [ 63 ] and extract biofilm parameters for treatment optimization.…”

Section: Discussionmentioning

confidence: 99%

Optimization of periodic treatment strategies for bacterial biofilms using an agent-based in silico approach

Blee,

Gorochowski,

Hauert

2024

J. R. Soc. Interface.

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Biofilms are responsible for most chronic infections and are highly resistant to antibiotic treatments. Previous studies have demonstrated that periodic dosing of antibiotics can help sensitize persistent subpopulations and reduce the overall dosage required for treatment. Because the dynamics and mechanisms of biofilm growth and the formation of persister cells are diverse and are affected by environmental conditions, it remains a challenge to design optimal periodic dosing regimens. Here, we develop a computational agent-based model to streamline this process and determine key parameters for effective treatment. We used our model to test a broad range of persistence switching dynamics and found that if periodic antibiotic dosing was tuned to biofilm dynamics, the dose required for effective treatment could be reduced by nearly 77%. The biofilm architecture and its response to antibiotics were found to depend on the dynamics of persister cells. Despite some differences in the response of biofilm governed by different persister switching rates, we found that a general optimized periodic treatment was still effective in significantly reducing the required antibiotic dose. As persistence becomes better quantified and understood, our model has the potential to act as a foundation for more effective strategies to target bacterial infections.

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Section: Discussionmentioning

confidence: 99%

Optimization of periodic treatment strategies for bacterial biofilms using an agent-based in silico approach

Blee,

Gorochowski,

Hauert

2024

J. R. Soc. Interface.

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“…An increasing area of interest in TDD is the use of microneedle arrays (MNs), also known as microarray patches, to mechanically breach the SC, epidermis and superficial dermis, therefore bypassing the skin's natural barrier function. 22–25 A number of different MN technologies exist including hollow, 26–28 coated, 29,30 dissolving, 31,32 hydrogel forming, 33,34 and solid MNs. 35–38 Solid MNs consist of sub-millimetre protrusions usually fabricated from metal or silicon.…”

Section: Introductionmentioning

confidence: 99%

Ex vivo transdermal delivery of ³H-labelled atovaquone solid drug nanoparticles: a comparison of topical, intradermal injection and microneedle assisted administration

Morris,

Long,

Savage

et al. 2023

Nanoscale Adv.

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Microneedle technology for enhanced topical treatment of skin infections

Peng,

Chen,

Luan

et al. 2025

Bioactive Materials

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Microarray patches for managing infections at a global scale

Cited by 9 publications

References 135 publications

Optimization of periodic treatment strategies for bacterial biofilms using an agent-based in silico approach

Optimization of periodic treatment strategies for bacterial biofilms using an agent-based in silico approach

Ex vivo transdermal delivery of ³H-labelled atovaquone solid drug nanoparticles: a comparison of topical, intradermal injection and microneedle assisted administration

Microneedle technology for enhanced topical treatment of skin infections

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Microarray patches for managing infections at a global scale

Cited by 9 publications

References 135 publications

Optimization of periodic treatment strategies for bacterial biofilms using an agent-based in silico approach

Optimization of periodic treatment strategies for bacterial biofilms using an agent-based in silico approach

Ex vivo transdermal delivery of 3H-labelled atovaquone solid drug nanoparticles: a comparison of topical, intradermal injection and microneedle assisted administration

Microneedle technology for enhanced topical treatment of skin infections

Contact Info

Product

Resources

About

Ex vivo transdermal delivery of ³H-labelled atovaquone solid drug nanoparticles: a comparison of topical, intradermal injection and microneedle assisted administration