Microbe-Induced Inflammatory Signals Triggering Acquired Bone Marrow Failure Syndromes

Espinoza, J. Luis; Kotecha, Ritesh; Nakao, Shinji

doi:10.3389/fimmu.2017.00186

Cited by 16 publications

(12 citation statements)

References 94 publications

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“…The community of commensal microorganisms living within the human intestines, known as gut microbiota, plays critical roles in maintaining immune tolerance and epithelial integrity ( 60 – 62 ).…”

Section: Dysbiosis and Nkg2d-ls Expressionmentioning

confidence: 99%

“…The loss of microbial balance and the overgrowth of pathogenic bacteria (known as dysbiosis) is often associated with the development of autoimmune disorders and the development of CRC ( 62 , 64 , 65 ). Strikingly, direct microbe-induced NKG2D-Ls upregulation has been documented in human intestinal epithelial cells exposed to Escherichia coli strains, where the interaction between bacterial adhesin AfaE and its cellular receptor CD55 results in MICA expression ( 66 ).…”

Section: Dysbiosis and Nkg2d-ls Expressionmentioning

confidence: 99%

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Sensing Bacterial-Induced DNA Damaging Effects via Natural Killer Group 2 Member D Immune Receptor: From Dysbiosis to Autoimmunity and Carcinogenesis

Espinoza

Minami

2018

Front. Immunol.

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The human genome is constantly exposed to exogenous and endogenous DNA damaging factors that frequently cause DNA damages. Unless repaired, damaged DNA can result in deleterious mutations capable of causing malignant transformation. Accordingly, cells have developed an advanced and effective surveillance system, the DNA damage response (DDR) pathway, which maintains genetic integrity. In addition to well-defined outcomes, such as cell cycle arrest, apoptosis, and senescence, another consequence of DDR activation is the induction of natural killer group 2 member D ligands (NKG2D-Ls) on the surface of stressed cells. Consequently, NKG2D-Ls-expressing cells are recognized and eliminated by NKG2D receptor-expressing immune cells, including NK cells, and various subsets of T-cells. Recent pieces of evidence indicate that commensal microbial imbalance (known as dysbiosis) can trigger DDR activation in host cells, which may result in sustained inflammatory responses. Therefore, dysbiosis can be seen as an important source of DNA damage agents that may be partially responsible for the overexpression of NKG2D-Ls on intestinal epithelial cells that is frequently observed in patients with inflammatory bowel disease and other disorders associated with altered human microbiota, including the development of colorectal cancer. In this article, we discuss recent evidence that appears to link an altered human microbiota with autoimmunity and carcinogenesis via the activation of DDR signals and the induction of NKG2D-Ls in stressed cells.

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Section: Dysbiosis and Nkg2d-ls Expressionmentioning

confidence: 99%

Section: Dysbiosis and Nkg2d-ls Expressionmentioning

confidence: 99%

Sensing Bacterial-Induced DNA Damaging Effects via Natural Killer Group 2 Member D Immune Receptor: From Dysbiosis to Autoimmunity and Carcinogenesis

Espinoza

Minami

2018

Front. Immunol.

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“…The commensal organisms (bacteria, viruses, and fungus) that colonize human body niches, including mouth, nose, skin, and gut are collectively known as microbiota [ 84 ]. Gut microbiota plays crucial roles in the development and education of immune system [ 84 , 85 ] and can regulate hematopoiesis [ 86 ]. Not surprisingly, and altered microbiota composition has been linked to various human disorders ranging from autoimmune diseases and cancer [ 87 , 88 ].…”

Section: Is Microbiota Implicated In the Pathogenesis Of Tak?mentioning

confidence: 99%

New Insights on the Pathogenesis of Takayasu Arteritis: Revisiting the Microbial Theory

Espinoza

Matsumura

2018

Pathogens

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Takayasu arteritis (TAK) is a chronic vasculitis that mainly affects the aorta, its major branches, and the pulmonary arteries. Since the description of the first case by Mikito Takayasu in 1908, several aspects of this rare disease, including the epidemiology, diagnosis, and the appropriate clinical assessment, have been substantially defined. Nevertheless, while it is well-known that TAK is associated with a profound inflammatory process, possibly rooted to an autoimmune disorder, its precise etiology has remained largely unknown. Efforts to identify the antigen(s) that trigger autoimmunity in this disease have been unsuccessful, however, it is likely that viruses or bacteria, by a molecular mimicry mechanism, initiate or propagate the auto-immune process in this disease. In this article, we summarize recent advances in the understanding of TAK, with emphasis on new insights related to the pathogenesis of this entity that may contribute to the design of novel therapeutic approaches.

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“…The microbiome and its associated metabolites have recently been functionally linked to hematopoiesis, as evidence suggests that the BM myeloid population strongly correlates with microflora complexity. 6 Recent publications have been demonstrated effects of the intestinal microbiome on hematopoiesis. For instance, the intestinal microbiome, suppressible with antibiotic therapy, plays an important role in stimulating bone marrow production of granulocytes as well as influencing activation and possibly retention of granulocytes in the circulation.…”

Section: Role Of Microbiota In Hematopoiesismentioning

confidence: 99%

The impact of microbiota on hematological disorders

Meowad

2017

Egyptian Journal of Hematology and Bone Marrow Transplantation

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The human body is host to 10 13 to 10 14 microbial organisms. The vast majority of these organisms are bacteria although viruses and fungi are also present at considerable amount and diversity. The gut is the main site of microbial colonization harboring a complex composition of bacteria referred to as the intestinal microbiota or sometimes as the intestinal microbiome. 1 Specifying the definition of the human microbiome has been complicated by confusion about terminology: "microbiota" (the microbial taxa associated with humans) and "microbiome" (the catalog of these microbes and their genes) are often used interchangeably. 2

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Microbe-Induced Inflammatory Signals Triggering Acquired Bone Marrow Failure Syndromes

Cited by 16 publications

References 94 publications

Sensing Bacterial-Induced DNA Damaging Effects via Natural Killer Group 2 Member D Immune Receptor: From Dysbiosis to Autoimmunity and Carcinogenesis

Sensing Bacterial-Induced DNA Damaging Effects via Natural Killer Group 2 Member D Immune Receptor: From Dysbiosis to Autoimmunity and Carcinogenesis

New Insights on the Pathogenesis of Takayasu Arteritis: Revisiting the Microbial Theory

The impact of microbiota on hematological disorders

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