Microbeam Proton Radiotherapy Allows for Greater Sparing of Periorbital Growth Plate and Vision Related Structures in Pediatric Cancer Patients with Orbital Primary Tumors

Abstract

partial cystectomy. Pathology revealed mature rhabdomyoblasts or cystitis cystica. Postoperatively, 4 of the 7 experienced grade 3 bladder toxicity, including prolonged hematuria, cystitis, and dysuria. Two of the 6 who underwent biopsy have nocturnal enuresis at age 7 and 9 years, compared to 0 of the 7 in the non-pseudoprogression cohort. Conclusion: In children undergoing proton therapy for unresectable pelvic rhabdomyosarcoma, pseudoprogression is common. Unnecessary intervention may result in more bladder toxicity than chemoradiotherapy itself.