Microbial 2,3-butanediol production: A state-of-the-art review

Ji, Xiao‐Jun; Huang, He; Ouyang, Pingkai

doi:10.1016/j.biotechadv.2011.01.007

Cited by 623 publications

(534 citation statements)

References 141 publications

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“…Sodium acetate as an inducer could increase the transcription level of 2,3-BD pathway in S. marcescens H30 and other 2,3-BD producing microbial strains (Zeng et al 1990;Ji et al 2011;Rao et al 2012), and further result in 2,3-BD accumulation during the fermentation process. The use of KH2PO4 could provide a phosphorus source for the growth of 2,3-BD producing strains (Zhang et al 2010a;Sun et al 2012).…”

Section: Effects Of Inorganic Salts On 23-bd Fermentationmentioning

confidence: 99%

“…During the fermentation process, oxygen supply was shown to be an important factor for 2,3-BD production in previous studies (Zeng et al 1994;Zhang et al 2010a;Ji et al 2011;Sun et al 2012). Therefore, it is necessary for the effect of oxygen supply on 2,3-BD production by S. marcescens H30 under the optimized medium to be investigated.…”

Section: Batch Fermentations With Various Agitation Speedsmentioning

confidence: 99%

“…Microbial production of 2,3-butanediol (2,3-BD) is one such example. As an important platform intermediate, 2,3-BD could be used to produce numerous other chemical compounds such as methylethyl ketone, butadiene, and butanone (Celinska and Grajek 2009;Ji et al 2011;Syu 2011;Adlakha and Yazdani 2015). It can also be used as a fuel additive due to its combustion heat energy of 27.2 kJ/g Yang et al 2015).…”

Section: Introductionmentioning

confidence: 99%

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Utilization of Sweet Sorghum Juice for Efficient 2,3-Butanediol Production by Serratia marcescens H30

Yuan¹,

He²,

Guo³

et al. 2017

BioResources

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Sweet sorghum juice (SSJ) is considered a good carbon source for biorefinery due to its low price and high fermentable-sugar content. In this study, 2,3-butanediol (2,3-BD) production from SSJ by Serratia marcescens H30 was investigated. First, the medium compositions including the contents of SSJ, nitrogen source, and mineral salts were optimized in conical flasks using a single factor and orthogonal design method. Under the optimal conditions, the 2,3-BD concentration reached up to 33.40 g/L. Then the optimized medium was used to perform fermentative experiments in a 5-L bioreactor. In batch experiments, the effects of various agitation speeds on 2,3-BD production were compared. Based on batch process results, an efficient two-stage fermentative control strategy was developed, where the agitation speed was maintained at 300 rpm in the first 12 h and subsequently switched to 200 rpm. About 43.32 g/L 2,3-BD was obtained by using this strategy. Finally, fed-batch fermentation was conducted through feeding the concentrated SSJ and a maximum 2,3-BD concentration of 109.44 g/L with the productivity of 1.40 g/L·h; a yield of 83.02% was achieved. The results showed that SSJ could be used as an economical substrate for efficient 2,3-BD production by S. marcescens H30.

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Section: Effects Of Inorganic Salts On 23-bd Fermentationmentioning

confidence: 99%

Section: Batch Fermentations With Various Agitation Speedsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Utilization of Sweet Sorghum Juice for Efficient 2,3-Butanediol Production by Serratia marcescens H30

Yuan¹,

He²,

Guo³

et al. 2017

BioResources

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“…Klebsiella pneumoniae can naturally convert glycerol into a series of economically important chemicals, including 1,3-propanediol (1,3-PD) [1], 2,3-butanediol (2,3-BD) [2], and 3-hydroxypropionic acid (3-HP) [3]. In K. pneumoniae, glycerol metabolism is mediated by the dha regulon which governs the parallel oxidation and reduction pathways [4].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Promoter Activity by Replenishment of Sigma Factor rpoE in Klebsiella pneumoniae

Chen

Tian

2016

Indian J Microbiol

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Plasmid-dependent overexpression of enzyme(s) aims to divert carbon flux toward a desired compound. One drawback of this strategy is compromise of growth due to massive consumption of host resources. Here we show that replenishment of sigma factor rpoE improves the growth of Klebsiella pneumoniae. The gene rpoE was expressed alone or coexpressed with Ald4 (an aldehyde dehydrogenase from Saccharomyces cerevisiae) in K. pneumoniae. We found that the Ald4 activity was higher in the strain coexpressing Ald4 and rpoE (32.3 U/mg) than that expressing Ald4 alone (29.9 U/mg). Additionally, under shake-flask conditions, the strain coexpressing Ald4 and rpoE produced 0.5 g 3-hydroxypropionic acid (3-HP) and 9.8 g 1,3-propanediol (1,3-PD) per liter in 24 h, which were 1.6-and 0.85-fold enhancement, respectively, compared to those expressing Ald4 alone. Notably, under nonoptimized bioreactor conditions, the strain coexpressing Ald4 and rpoE produced 13.5 g 3-HP and 37.8 g 1,3-PD per liter with glycerol conversion ratio of 0.45 mol/mol. These results indicate that replenishment of rpoE enhanced promoter activity and stimulated glycerol consumption.

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“…Therefore, studies for improving the production of 2,3-BD by fermentation such as strain screening and optimization of fermentation condition, have significantly increased [2]. Compared with these efforts devoted to upstream processing, similar efforts for downstream processing are just beginning.…”

Section: Introductionmentioning

confidence: 99%

Extraction of 2,3-Butanediol with Aqueous Two-Phase Systems Formed by Water-Miscible Organic Solvents and Inorganic Salts

Matsumoto

Okuno

Kondo

2014

SERDJ

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2,3-Butanediol is one of the bulk chemicals that exhibits a wide range of potential uses in cosmetics and transport fuels as well as being a precursor of synthetic rubbers. During the last few decades, considerable efforts have been made to improve the production of 2,3-butanediol from fermentation. However, major difficulties still exist in downstream processing because 2,3-butanediol has a high boiling point and a high affinity for water. In this study, aqueous two phase systems composed of water-miscible solvents and salts could be used to extract 2,3-butanediol from a model solution. We used t-butanol, tetrahydrofuran and 2-propanol as water-miscible solvents, and dipotassium hydrogen phosphate, tripotassium phosphate, potassium carbonate, potassium fluoride and tripotassium citrate as salts. The phase separation abilities of water-miscible solvents and the salting-out abilities of salts were evaluated by the difference in the binodal curves and salting-out of 2,3-butanediol. t-Butanol and tetrahydrofuran showed high phase separation abilities, and potassium carbonate showed as high a salting-out ability as conventional phosphate salts. The concentration in the top phase and recovery ratio of 2,3-butanediol reached 184.3 g/L and 92.2%, respectively, when the system was composed of tetrahydrofuran and potassium carbonate. This process provided the possibility of a simple and economical process for the separation of 2,3-butanediol from fermentation broth.

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Microbial 2,3-butanediol production: A state-of-the-art review

Cited by 623 publications

References 141 publications

Utilization of Sweet Sorghum Juice for Efficient 2,3-Butanediol Production by Serratia marcescens H30

Utilization of Sweet Sorghum Juice for Efficient 2,3-Butanediol Production by Serratia marcescens H30

Enhanced Promoter Activity by Replenishment of Sigma Factor rpoE in Klebsiella pneumoniae

Extraction of 2,3-Butanediol with Aqueous Two-Phase Systems Formed by Water-Miscible Organic Solvents and Inorganic Salts

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