Microbial Associations and Response to Antimicrobials Seen in a Psoriasis Clinic

Belew-Noah, Patricia W.; Rosenberg, William E.; Zabriskie, John B.; Skinner, Robert B.; Henson, Terri H.; Beard, Gwen

doi:10.1007/978-1-4899-1825-3_38

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…Following frequent reports of PRP development after bacterial and viral infections, the possibility of PRP being triggered by immune system stimulation is also considered [1]. There are literature reports of patients experiencing a remission of PRP symptoms after treatment of the accompanying infection [32,33]. Interestingly, patients with chronic periodontitis were shown to have increased lymphocyte differentiation towards Th17 cells, which, in addition to their protective function against infectious agents, are also an important element in the pathogenesis of PRP and other inflammatory skin diseases [34].…”

Section: Discussionmentioning

confidence: 99%

Pityriasis rubra pilaris secondary to viral infection

Pawlik,

Jarosz-Chudek,

Dyduch

et al. 2023

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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) Dermatology Review/Przegląd Dermatologiczny 2023/5 620 of Dermatology (OKD) of the University Hospital in Krakow, who developed symptoms of PRP after a viral infection, and provide insights into the nature of the disease. Case reportA 67-year-old male patient, a retired entrepreneur, was admitted to the OKD for the diagnosis and treatment of rapidly progressive erythematous papular skin rash. The first skin lesions, presenting as erythema on the face and palms, appeared approximately 2 weeks prior to hospitalisation. Subsequently, ery-abstraCt Introduction: Pityriasis rubra pilaris is a rare, chronic dermatosis presenting with erythema and papular eruptions as well as characteristic perifollicular hyperkeratosis and 'islands of sparing' (normal appearing skin). In the literature, there are reports of cases where symptoms of infection preceded the onset of pityriasis rubra pilaris. Objective: Presentation of the case of a 67-year-old patient with type I pityriasis rubra pilaris to highlight the possible association between pityriasis rubra pilaris with infectious agents. Case report: A 67-year-old patient was referred to hospital because of rapidly progressive erythematous papular skin rash preceded by symptoms of an upper respiratory tract infection. On physical examination, attention was drawn to perifollicular papules covered with cap-like scales as well as confluent erythema and features of hyperkeratosis on the hands and feet. Based on the clinical presentation and histopathological findings, type I pityriasis rubra pilaris was diagnosed and treatment with acitretin was initiated. Conclusions: Infectious agents have the potential to be a trigger for pityriasis rubra pilaris. Acitretin continues to demonstrate efficacy in the treatment of pityriasis rubra pilaris.

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Section: Discussionmentioning

confidence: 99%

Pityriasis rubra pilaris secondary to viral infection

Pawlik,

Jarosz-Chudek,

Dyduch

et al. 2023

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Antistreptococcal treatment of psoriasis: a systematic review

Sitton,

Walker,

Mital

et al. 2024

Arch Dermatol Res

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Streptococcal infections may contribute to psoriasis development, and antistreptococcal treatments are considered potential therapies, but their effectiveness remains uncertain due to limited systematic evidence. Our objective was to analyze antistreptococcal therapies' effectiveness in improving psoriasis. We conducted a systematic review following PRISMA guidelines, evaluating antistreptococcal treatment efficacy in psoriasis patients from PubMed, Scopus, and Embase databases until August 14, 2022. Eligible studies included psoriasis patients undergoing antistreptococcal therapy, regardless of demographics or psoriasis type. 50 studies (1778 patients) were analyzed, with penicillins/aminopenicillins as the most studied antibiotics (21 studies), showing mixed outcomes, some reporting significant improvement in guttate psoriasis, while others showed no significant difference. Rifampin demonstrated positive results in most of ten studies, and macrolides showed varying effectiveness in two studies. Tonsillectomy in 14 studies (409 patients) mainly focusing on guttate and chronic plaque psoriasis showed positive outcomes, indicating improved symptoms and quality of life. Limitations include heterogeneous studies, sampling bias, and quality of evidence. This systematic review reveals limited and varied evidence for systemic antibiotic therapy efficacy in psoriasis treatment, while tonsillectomy emerges as a potentially beneficial antistreptococcal option, urging further well-designed, controlled studies with larger sample sizes and standardized protocols for better comparisons.

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Microbial Associations and Response to Antimicrobials Seen in a Psoriasis Clinic

Cited by 2 publications

References 8 publications

Pityriasis rubra pilaris secondary to viral infection

Pityriasis rubra pilaris secondary to viral infection

Antistreptococcal treatment of psoriasis: a systematic review

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