Microbial contamination profile change over a 4‐year period in nonoperated cleft soft palate

Roode, G.J.; Bütow, Kurt-Wilhelm; Naidoo, Sharan

doi:10.1111/jam.15193

Cited by 3 publications

(6 citation statements)

References 65 publications

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“…Other studies sampled from part or all of the palate and the nasopharynx or oro-nasopharynx have identified H. influenzae , S. aureus , and S. viridans as being prevalent and K . pneumoniae as being moderately prevalent at these sites ( Mÿburgh and Bütow, 2009 ; Roode et al., 2017 ; Roode and Bütow, 2018 ; Ramdial and Madaree, 2019 ; Roode et al., 2022 ). Interestingly, Narinesingh et al.…”

Section: Resultsmentioning

confidence: 97%

“…Many studies ( Chuo and Timmons, 2005 ; Mÿburgh and Bütow, 2009 ; Narinesingh et al., 2011 ; Thomas et al., 2012 ; Bos et al., 2016 ; Roode et al., 2017 ; Roode and Bütow, 2018 ; Ramdial and Madaree, 2019 ; Roode et al., 2022 ) have examined the pharyngeal mucosa in combination with that of the ear, nose, and the palate or palatal cleft ( Supplementary Table S5 ). Two publications ( Narinesingh et al., 2011 ; Thomas et al., 2012 ) evaluating nasal and/or pharyngeal samples and one publication ( Chuo and Timmons, 2005 ) evaluating ear, nose, and throat mucosa samples reported S. aureus as prevalent in CL/P subjects.…”

Section: Resultsmentioning

confidence: 99%

“…Two studies done by Roode et al. in 2018 and 2022 evaluating the nasopharynx and the palatal cleft or cleft palate, respectively, reported a high prevalence of S. mitis and S. oralis combined ( Roode and Bütow, 2018 ; Roode et al., 2022 ). Other studies sampled from part or all of the palate and the nasopharynx or oro-nasopharynx have identified H. influenzae , S. aureus , and S. viridans as being prevalent and K .…”

Section: Resultsmentioning

confidence: 99%

“…In contrast, a study that solely sampled the throat did not find S. aureus to be prevalent (Rennie et al, 2009). Two studies done by Roode et al in 2018 and2022 evaluating the nasopharynx and the palatal cleft or cleft palate, respectively, reported a high prevalence of S. mitis and S. oralis combined (Roode and Bütow, 2018;Roode et al, 2022). Other studies sampled from part or all of the palate and the nasopharynx or oro-nasopharynx have identified H. influenzae, S. aureus, and S. viridans as being prevalent and K. pneumoniae as being moderately prevalent at these sites (Mÿburgh and Bütow, 2009;Roode et al, 2017;Roode and Bütow, 2018;Ramdial and Madaree, 2019;Roode et al, 2022).…”

Section: The Oral Mucosamentioning

confidence: 98%

“…Two studies done by Roode et al in 2018 and2022 evaluating the nasopharynx and the palatal cleft or cleft palate, respectively, reported a high prevalence of S. mitis and S. oralis combined (Roode and Bütow, 2018;Roode et al, 2022). Other studies sampled from part or all of the palate and the nasopharynx or oro-nasopharynx have identified H. influenzae, S. aureus, and S. viridans as being prevalent and K. pneumoniae as being moderately prevalent at these sites (Mÿburgh and Bütow, 2009;Roode et al, 2017;Roode and Bütow, 2018;Ramdial and Madaree, 2019;Roode et al, 2022). Interestingly, Narinesingh et al noticed an association between Moraxella catarrhalis infection and oronasal fistula formation in CL/P patients; however, this species was far from prevalent in the nasal mucosa of the study's subjects (Narinesingh et al, 2011).…”

Section: The Oral Mucosamentioning

confidence: 99%

See 4 more Smart Citations

Characterizing the microbiota of cleft lip and palate patients: a comprehensive review

Gershater

Liu

Xue

et al. 2023

Front. Cell. Infect. Microbiol.

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Orofacial cleft disorders, including cleft lip and/or palate (CL/P), are one of the most frequently-occurring congenital disorders worldwide. The health issues of patients with CL/P encompass far more than just their anatomic anomaly, as patients with CL/P are prone to having a high incidence of infectious diseases. While it has been previously established that the oral microbiome of patients with CL/P differs from that of unaffected patients, the exact nature of this variance, including the relevant bacterial species, has not been fully elucidated; likewise, examination of anatomic locations besides the cleft site has been neglected. Here, we intended to provide a comprehensive review to highlight the significant microbiota differences between CL/P patients and healthy subjects in various anatomic locations, including the teeth inside and adjacent to the cleft, oral cavity, nasal cavity, pharynx, and ear, as well as bodily fluids, secretions, and excretions. A number of bacterial and fungal species that have been proven to be pathogenic were found to be prevalently and/or specifically detected in CL/P patients, which can benefit the development of CL/P-specific microbiota management strategies.

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: The Oral Mucosamentioning

confidence: 98%

Section: The Oral Mucosamentioning

confidence: 99%

See 3 more Smart Citations

Characterizing the microbiota of cleft lip and palate patients: a comprehensive review

Gershater

Liu

Xue

et al. 2023

Front. Cell. Infect. Microbiol.

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Detection of multidrug-resistant bacteria in the nasal cavities and evaluation of sinus disorders in patients undergoing Le Fort I osteotomy

Mendes,

Bortoli,

Zaleski

et al. 2024

BMC Oral Health

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Introduction Orthognathic surgery can lead to sinus alterations, including sinusitis, attributed to the exposure of maxillary sinuses during Le Fort I osteotomy. Furthermore, being a hospital-based procedure, there is potential risk of complications arising from bacteria prevalent in such environments. This study evaluated maxillary sinusitis occurrence and the presence of multidrug-resistant bacteria in the nasal cavity before and after orthognathic surgery. Methods Ten patients with dentofacial deformities underwent Le Fort I osteotomy. Clinical evaluations using SNOT-22 questionnaire were performed, and nasal cavity samples were collected pre-surgery and 3–6 months post-surgery to quantify total mesophilic bacteria and detect Staphylococcus aureus, Acinetobacter baumannii, and Klebsiella pneumoniae. Cone Beam Computed Tomography (CBCT) was performed pre- and post-operatively, and the results were evaluated using the Lund-Mackay system. This study was registered and approved by the Research Ethics Committee of PUCRS (No. 4.683.066). Results The evaluation of SNOT-22 revealed that five patients showed an improvement in symptoms, while two remained in the same range of interpretation. One patient developed post-operative maxillary sinusitis, which was not detected at the time of evaluation by SNOT-22 or CBCT. CBCT showed a worsening sinus condition in three patients, two of whom had a significant increase in total bacteria count in their nasal cavities. The Brodsky scale was used to assess hypertrophy in palatine tonsils, where 60% of the subjects had grade 1 tonsils, 20% had grade 2 and 20% had grade 3. None of the patients had grade 4 tonsils, which would indicate more than 75% obstruction. Two patients harboured S. aureus and K. pneumoniae in their nasal cavities. Notably, K. pneumoniae, which was multidrug-resistant, was present in the nasal cavity of patients even before surgery, but this did not result in maxillary sinusitis, likely due to the patients’ young and healthy condition. Conclusion There was an improvement in signs and symptoms of maxillary sinusitis and quality of life in most patients after orthognathic surgery. However, some patients may still harbour multidrug-resistant bacteria, even if they are asymptomatic. Therefore, a thorough pre-operative assessment is essential to avoid difficult-to-treat post-operative complications.

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Paediatric Facial Cleft Treatment - Lessons Learned

Zwahlen

2024

JDHOR

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The title of this publication includes the words “Lessons Learned” in order to emphasise the knowledge and experience gained in more than 4 decades in treating 5000+ patients with facial-oral cleft anomalies. The choice, timing and optimization of the most appropriate paediatric surgical and paediatric orthodontic treatments are reflected in the extremely satisfactory treatment outcomes. This paper delineates hierarchically the conceptual framework of treatment for the most profound to the least severe cleft anomaly. Over the years multiple treatment techniques, options and protocols have been published internationally and yet the young professionals often use the procedures and timing of interventions they have learned from their ‘masters’ or seniors, irrespective of whether these have been chosen based on the best long-term treatment outcomes. This paper advocates specific treatment protocols and techniques, based on the results of research, on observation, clinical evaluation, judgement of outcome and the ideal treatment of a specific type of cleft anomaly, in order to optimize long-term outcomes. The initial short-term result, as well as the long-term facial growth, functional and aesthetic influence or their combined influence, have been recorded until the onset of the adolescence age. The application of technique(s) appropriate for treatment of a particular type of cleft anomaly are described and motivated for use, without mention the so-called original or first person who applied or described or used a particular technique or procedure for the first time. Conversely, those treatment technique(s) utilized during the very important developmental phases of the neonate, the infant and the child and which have had a profoundly negative effect on function and/or facial growth and/or facial aesthetic in the long-term, are also described, without mention the name of the person(s) who advocated their use. Paediatric patients who have been treated by means of these latter surgical techniques or interventions which may lead to undesirable or insufficiently positive outcomes, may require extensive drawn-out surgical restructuring and orthodontic treatment during their adolescent’s years.

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Microbial contamination profile change over a 4‐year period in nonoperated cleft soft palate

Cited by 3 publications

References 65 publications

Characterizing the microbiota of cleft lip and palate patients: a comprehensive review

Characterizing the microbiota of cleft lip and palate patients: a comprehensive review

Detection of multidrug-resistant bacteria in the nasal cavities and evaluation of sinus disorders in patients undergoing Le Fort I osteotomy

Paediatric Facial Cleft Treatment - Lessons Learned

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