Microbial-derived antigens and metabolites in spondyloarthritis

Yang, Katharine; Lejeune, Alannah; Chang, Gregory; Scher, Jose U.; Koralov, Sergei B.

doi:10.1007/s00281-021-00844-1

Cited by 12 publications

(8 citation statements)

References 90 publications

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“…Moreover, gut microbiome may evolve together with the human hosts and provide them with a myriad of molecules such as microbe-associated molecular patterns (MAMPs) to augment intestinal inflammatory processes. In association with damage-associated molecular patterns (DAMPs), the inflammatory processes may be triggered further in the already ongoing pathological status such as HLA-B27-associated acute anterior uveitis ( Rosenbaum and Asquith, 2018 ; Lu Yang et al, 2021 ). These data support that the invisible “essential organs” can communicate with each other and “talk” across with host immune cells in healthy individuals as well as in AS patients.…”

Section: Roles Of Hazard Hla Allele-associated Gut Dysbiosis and Its Metabolites In The Pathogenesis Of Asmentioning

confidence: 99%

The Potential Role of Genetics, Environmental Factors, and Gut Dysbiosis in the Aberrant Non-Coding RNA Expression to Mediate Inflammation and Osteoclastogenic/Osteogenic Differentiation in Ankylosing Spondylitis

Liao

Tsai

Lai

et al. 2022

Front. Cell Dev. Biol.

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Ankylosing spondylitis (AS) or radiographic axial spondyloarthritis is a chronic immune-mediated rheumatic disorder characterized by the inflammation in the axial skeleton, peripheral joints, and soft tissues (enthesis, fascia, and ligament). In addition, the extra-skeletal complications including anterior uveitis, interstitial lung diseases and aortitis are found. The pathogenesis of AS implicates an intricate interaction among HLA (HLA-B27) and non-HLA loci [endoplasmic reticulum aminopeptidase 1 (ERAP1), and interleukin-23 receptor (IL23R), gut dysbiosis, immune plasticity, and numerous environmental factors (infections, heavy metals, stress, cigarette smoking, etc.) The latter multiple non-genetic factors may exert a powerful stress on epigenetic regulations. These epigenetic regulations of gene expression contain DNA methylation/demethylation, histone modifications and aberrant non-coding RNAs (ncRNAs) expression, leading to inflammation and immune dysfunctions. In the present review, we shall discuss these contributory factors that are involved in AS pathogenesis, especially the aberrant ncRNA expression and its effects on the proinflammatory cytokine productions (TNF-α, IL-17 and IL-23), T cell skewing to Th1/Th17, and osteoclastogenic/osteogenic differentiation. Finally, some potential investigatory approaches are raised for solving the puzzles in AS pathogenesis.

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Section: Roles Of Hazard Hla Allele-associated Gut Dysbiosis and Its Metabolites In The Pathogenesis Of Asmentioning

confidence: 99%

The Potential Role of Genetics, Environmental Factors, and Gut Dysbiosis in the Aberrant Non-Coding RNA Expression to Mediate Inflammation and Osteoclastogenic/Osteogenic Differentiation in Ankylosing Spondylitis

Liao

Tsai

Lai

et al. 2022

Front. Cell Dev. Biol.

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“…The communication between the gut and other organs and tissues is mainly mediated by microbial metabolites and immunity modulation [61] Gut and lung microbiota are different, both in terms of abundance and in terms of composition, even if there are some structural and functional similarities between lung and gut epithelium [62]. The different composition is due to the existing differences in oxygen availability.…”

Section: The Lung-gut Axis and The Influence Of The Microbiota On The...mentioning

confidence: 99%

The Interaction among Microbiota, Epigenetic Regulation, and Air Pollutants in Disease Prevention

Pulliero

Traversi²,

Franchitti³

et al. 2021

JPM

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Environmental pollutants can influence microbiota variety, with important implications for the general wellbeing of organisms. In subjects at high-risk of cancer, gut, and lung microbiota are distinct from those of low-risk subjects, and disease progression is associated with microbiota alterations. As with many inflammatory diseases, it is the combination of specific host and environmental factors in certain individuals that provokes disease outcomes. The microbiota metabolites influence activity of epigenetic enzymes. The knowledge of the mechanisms of action of environmental pollution now includes not only the alteration of the gut microbiota but also the interaction between different human microbiota niches such as the lung–gut axis. The epigenetic regulations can reprogram differentiated cells in response to environmental changes. The microbiota can play a major role in the progression and suppression of several epigenetic diseases. Accordingly, the maintenance of a balanced microbiota by monitoring the environmental stimuli provides a novel preventive approach for disease prevention. Metagenomics technologies can be utilized to establish new mitigation approaches for diseases induced by polluted environments. The purpose of this review is to examine the effects of particulate matter exposure on the progression of disease outcomes as related to the alterations of gut and lung microbial communities and consequent epigenetic modifications.

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“…One such association is the finding of increased levels of sulphate-reducing bacteria in the faecal samples of those with AS [ 78 ]. Sulphate-reducing bacteria catalyse the reduction of inorganic sulphate to hydrogen sulphide [ 79 ], and increased levels of this metabolic product have been demonstrated in the intestinal lumen of those with AS [ 78 ]. Although a convincing association has been drawn, undeniably further studies are required to establish a causative relationship, in addition to identifying the precise pathogenic mechanism that these sulphate-reducing bacteria play in disease development.…”

Section: Reviewmentioning

confidence: 99%

‘All disease begins in the gut’—the role of the intestinal microbiome in ankylosing spondylitis

Harkins¹,

Burke

Swales

et al. 2021

Rheumatology Advances in Practice

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Ankylosing spondylitis is a chronic debilitating arthritis with a predilection for the axial skeleton. It has a strong genetic predisposition, however, the precise pathogenetic mechanisms involved in its development have not yet been fully elucidated. This has implications both for early diagnosis and also effective management. Recently, alterations in the intestinal microbiome have been implicated in disease pathogenesis. In this review we summarise studies assessing the intestinal microbiome in ankylosing spondylitis pathogenesis, in addition to synthesising the literature exploring the postulated mechanisms by which it exerts it pathogenic potential. Finally we will review studies analysing manipulation of the microbiome as a potential therapeutic avenue in ankylosing spondylitis management.

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Microbial-derived antigens and metabolites in spondyloarthritis

Cited by 12 publications

References 90 publications

The Potential Role of Genetics, Environmental Factors, and Gut Dysbiosis in the Aberrant Non-Coding RNA Expression to Mediate Inflammation and Osteoclastogenic/Osteogenic Differentiation in Ankylosing Spondylitis

The Potential Role of Genetics, Environmental Factors, and Gut Dysbiosis in the Aberrant Non-Coding RNA Expression to Mediate Inflammation and Osteoclastogenic/Osteogenic Differentiation in Ankylosing Spondylitis

The Interaction among Microbiota, Epigenetic Regulation, and Air Pollutants in Disease Prevention

‘All disease begins in the gut’—the role of the intestinal microbiome in ankylosing spondylitis

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