Microbial killing by NK cells

Mody, Christopher H.; Ogbomo, Henry; Xiang, Richard F.; Kyei, Stephen K.; Feehan, David; Islam, Anowara; Li, Shu Shun

doi:10.1002/jlb.mr0718-298r

Cited by 18 publications

(22 citation statements)

References 126 publications

(239 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ILCs can be divided into three groups based on the expression of transcriptional factors and cytokines [47]: group 1 ILCs, which include natural killer (NK) cells and ILC1s; group 2 ILCs, which consist of ILC2; and group 3 ILCs, which consist of lymphoid tissue inducer cells and NKp46and NKp46 + ILC3s [48]. NK cells possess microbicidal activity against a diverse group of pathogens, which not only kill tumor cells and microbes but also regulate the activity of other immune cells, such as macrophages and DCs [49]. NK cells are barely detectable in both the intra-follicle and peri-follicle cells of PCOS patients and healthy controls [50].…”

Section: Innate Lymphoid Cells (Ilcs)mentioning

confidence: 99%

Immunophenotypic Profiles in Polycystic Ovary Syndrome

Pang

et al. 2020

Mediators of Inflammation

View full text Add to dashboard Cite

Polycystic ovary syndrome (PCOS) a long-known endocrinopathy and one of the most common endocrine-reproductivemetabolic disorders in women, which can lead to infertility. Although the precise etiology remains unclear, PCOS is considered as a complex genetic trait, with a high degree of heterogeneity. Besides, hormones and immune cells, including both innate and adaptive immune cells, are reportedly a cross talk in PCOS. Chronic low-grade inflammation increases autoimmune disease risk. This proinflammatory condition may, in turn, affect vital physiological processes that ultimately cause infertility, such as ovulation failure and embryo implantation. Here, we review the accumulating evidence linking PCOS with inflammatory status providing an overview of the underlying hormone-mediated dysregulation of immune cells. We mainly focus on the correlational evidence of associations between immune status in women and the increased prevalence of PCOS, along with the specific changes in immune responses. Further recognition and exploration of these interactions may help elucidate PCOS pathophysiology and highlight targets for its treatment and prevention.

show abstract

Section: Innate Lymphoid Cells (Ilcs)mentioning

confidence: 99%

Immunophenotypic Profiles in Polycystic Ovary Syndrome

Pang

et al. 2020

Mediators of Inflammation

View full text Add to dashboard Cite

show abstract

“…Natural killer (NK) cells are lymphocytes of the innate immune system that participate in early defense against foreign cells and autologous cells undergoing various forms of stress, such as microbial infection or tumour transformation [1, 2]. NK cells are derived from a common lymphoid progenitor and develop primarily in the bone marrow [2].…”

Section: Introductionmentioning

confidence: 99%

Contributions of natural killer cells to the immune response against Plasmodium

Burrack

Hart

Hamilton

2019

Malar J

View full text Add to dashboard Cite

Natural killer (NK) cells are important innate effector cells that are well described in their ability to kill virally-infected cells and tumors. However, there is increasing appreciation for the role of NK cells in the control of other pathogens, including intracellular parasites such as Plasmodium, the cause of malaria. NK cells may be beneficial during the early phase of Plasmodium infection—prior to the activation and expansion of antigen-specific T cells—through cooperation with myeloid cells to produce inflammatory cytokines like IFNγ. Recent work has defined how Plasmodium can activate NK cells to respond with natural cytotoxicity, and inhibit the growth of parasites via antibody-dependent cellular cytotoxicity mechanisms (ADCC). A specialized subset of adaptive NK cells that are negative for the Fc receptor γ chain have enhanced ADCC function and correlate with protection from malaria. Additionally, production of the regulatory cytokine IL-10 by NK cells prevents overt pathology and death during experimental cerebral malaria. Now that conditional NK cell mouse models have been developed, previous studies need to be reevaluated in the context of what is now known about other immune populations with similarity to NK cells (i.e., NKT cells and type I innate lymphoid cells). This brief review summarizes recent findings which support the potentially beneficial roles of NK cells during Plasmodium infection in mice and humans. Also highlighted are how the actions of NK cells can be explored using new experimental strategies, and the potential to harness NK cell function in vaccination regimens.

show abstract

“…In summary, a growing body of evidence suggests that NK cells have the capacity to mount memory or memory-like responses to a diverse range of viral and bacterial pathogens, and possibly even eukaryotic pathogens such as Plasmodium falciparum (Table 1 and Figure 1). It will be interesting to see whether future studies uncover memory NK responses against other eukaryotic organisms, and in particular the various fungal pathogens controlled by NK-mediated host defenses (reviewed in Ogbomo and Mody, 2016;Mody et al, 2019). In some experimental models, memory NK responses are clearly pathogen-specific.…”

Section: Discussionmentioning

confidence: 99%

Memory and Memory-Like NK Cell Responses to Microbial Pathogens

Brillantes

Beaulieu

2020

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

NK cells are cytotoxic lymphocytes that provide systemic defense against pathogens and malignancy. Although historically considered cells of the innate immune system, NK cells are now known to be capable of memory or memory-like immune responses in certain settings. Memory NK responses were initially reported over a decade ago in studies involving mouse models of cytomegalovirus infection and delayed-type hypersensitivity reactions to chemical haptens and viral antigens. Since then, a growing body of literature suggests that memory or memory-like NK cell responses may occur in a broader range of immunological settings, including in response to various viral and bacterial infections, and some immunization protocols. Memory-like NK cell responses have also now been reported in humans and non-human primates. Here, we summarize recent studies demonstrating memory or memory-like responses by NK cells in settings of infection and immunization against infectious agents.

show abstract

Microbial killing by NK cells

Cited by 18 publications

References 126 publications

Immunophenotypic Profiles in Polycystic Ovary Syndrome

Immunophenotypic Profiles in Polycystic Ovary Syndrome

Contributions of natural killer cells to the immune response against Plasmodium

Memory and Memory-Like NK Cell Responses to Microbial Pathogens

Contact Info

Product

Resources

About