Microbial Metabolomics’ Latest SICRIT: Soft Ionization by Chemical Reaction In-Transfer Mass Spectrometry

McAtamney, Allyson; Ferranti, Allison; Ludvik, Denise A.; Yildiz, Fitnat H.; Mandel, Mark J.; Hayward, Taylor; Sanchez, Laura M.

doi:10.1021/jasms.4c00309

J. Am. Soc. Mass Spectrom.

2024

DOI: 10.1021/jasms.4c00309

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Microbial Metabolomics’ Latest SICRIT: Soft Ionization by Chemical Reaction In-Transfer Mass Spectrometry

Allyson McAtamney,

Allison Ferranti,

Denise A. Ludvik

et al.

Abstract: A graphical representation of the LC-SICRIT apparatus, violin plots of precursor masses, a 5 × 5 representation of principal components 1−5, EICs of analytes of interest, comprehensive molecular networks, mirror matched plots of MS/MS data for specific analytes, and detailed materials and methods (PDF)

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Gut microbiota and microbial metabolites for osteoporosis

Zheng,

Wang,

Jiang

et al. 2024

Gut Microbes

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Osteoporosis is an age-related bone metabolic disease. As an essential endocrine organ, the skeletal system is intricately connected with extraosseous organs. The crosstalk between bones and other organs supports this view. In recent years, the link between the gut microecology and bone metabolism has become an important research topic, both in preclinical studies and in clinical trials. Many studies have shown that skeletal changes are accompanied by changes in the composition and structure of the gut microbiota (GM). At the same time, natural or artificial interventions targeting the GM can subsequently affect bone metabolism. Moreover, microbiome-related metabolites may have important effects on bone metabolism. We aim to review the relationships among the GM, microbial metabolites, and bone metabolism and to summarize the potential mechanisms involved and the theory of the gut‒bone axis. We also describe existing bottlenecks in laboratory studies, as well as existing challenges in clinical settings, and propose possible future research directions.

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Gut microbiota and microbial metabolites for osteoporosis

Zheng,

Wang,

Jiang

et al. 2024

Gut Microbes

View full text Add to dashboard Cite

show abstract

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Microbial Metabolomics’ Latest SICRIT: Soft Ionization by Chemical Reaction In-Transfer Mass Spectrometry

Cited by 1 publication

References 39 publications

Gut microbiota and microbial metabolites for osteoporosis

Gut microbiota and microbial metabolites for osteoporosis

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