Microbial Transformations of Pentacyclic Triterpenes

Azerad, Robert

doi:10.1002/9781118828083.ch28

Cited by 2 publications

(3 citation statements)

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“…Henceforth, the interest in the topic discussed has been increasing and the Active Triterpenoid Biocatalysts List has been expanded every year, as is the number of various bioactive triterpenic derivatives formed via biotransformations [30][31][32]. Now, preparation of biologically active compounds based on pentacyclic triterpenoids is an actual research discussed in plenty of experimental and review publications [8,12,[32][33][34]. However, the reviews are overwhelmingly focused on chemical transformations or describe specific types of biological activities of triterpenoids.…”

Section: Distribution In Naturementioning

confidence: 99%

“…Now, preparation of biologically active compounds based on pentacyclic triterpenoids is an actual research discussed in plenty of experimental and review publications [ 8 , 12 , 32 , 33 , 34 ]. However, the reviews are overwhelmingly focused on chemical transformations or describe specific types of biological activities of triterpenoids.…”

Section: Introductionmentioning

confidence: 99%

“…Less frequently, they deal with biological transformations. The latest of the few reviews on microbial transformations of pentacyclic triterpenoids include literature data up to 2016 [ 12 , 32 , 33 , 35 ]. Our review summarizes the data from 2013 to the present on distribution, microbial biosynthesis, biological activity, and mainly biotransformation of oleanane and ursane pentacyclic triterpenoids to obtain promising biologically active compounds or intermediates of their synthesis.…”

Section: Introductionmentioning

confidence: 99%

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Biotransformation of Oleanane and Ursane Triterpenic Acids

2020

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Oleanane and ursane pentacyclic triterpenoids are secondary metabolites of plants found in various climatic zones and regions. This group of compounds is highly attractive due to their diverse biological properties and possible use as intermediates in the synthesis of new pharmacologically promising substances. By now, their antiviral, anti-inflammatory, antimicrobial, antitumor, and other activities have been confirmed. In the last decade, methods of microbial synthesis of these compounds and their further biotransformation using microorganisms are gaining much popularity. The present review provides clear evidence that industrial microbiology can be a promising way to obtain valuable pharmacologically active compounds in environmentally friendly conditions without processing huge amounts of plant biomass and using hazardous and expensive chemicals. This review summarizes data on distribution, microbial synthesis, and biological activities of native oleanane and ursane triterpenoids. Much emphasis is put on the processes of microbial transformation of selected oleanane and ursane pentacyclic triterpenoids and on the bioactivity assessment of the obtained derivatives.

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