Microbicidal effect of deep ultraviolet light-emitting diode irradiation

Takagi, Tatsuya; Nishikawa, Jun; Yanagihara, Masashi; Fukuda, Soichiro; Kubota, Naoto; Kobayashi, Yuki; Otsuyama, Ken-ichiro; Nojima, Junzo; Tsuneoka, Hidehiro; Sakai, Kohei; Suehiro, Yutaka; Yamasaki, Takahiro; K, Sakurai; Itatani, Kazuki; Sakaida, Isao

doi:10.1007/s10103-020-03143-7

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…In terms of the 275-nm UVC-LED lamp tube itself, in contrast to the 222-nm wavelength, the 275-nm UVC-LED light source has been made commercially available. In addition, it is a relatively inexpensive and high-quality light source which can be accessed from the market ( 40 ). Therefore, it is convenient for the design and mass production of the lamp tubes.…”

Section: Discussionmentioning

confidence: 99%

“…It has not yet attained widespread use. The emergence of the light-emitting diode (LED) light source provides a new option for UVC sterilization and realizes the continuously tunable wavelength ( 40 ). There has been limited research on the 265-nm wavelength ( 34 , 41 – 45 ) and 280-nm wavelength ( 46 – 49 ) for treatment recently.…”

Section: Introductionmentioning

confidence: 99%

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UV C Light from a Light-Emitting Diode at 275 Nanometers Shortens Wound Healing Time in Bacterium- and Fungus-Infected Skin in Mice

et al. 2022

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

UV C Light from a Light-Emitting Diode at 275 Nanometers Shortens Wound Healing Time in Bacterium- and Fungus-Infected Skin in Mice

et al. 2022

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“…LEDs are semiconductor devices that emit light and are ideal for downsizing equipment [ 24 ]. Recently, LEDs that can emit ultraviolet light have been developed [ 25 ], and we have confirmed that DUV-LEDs have various bactericidal effects against bacteria and fungi in vitro [ 26 ]. In the present study, the bactericidal effect of DUV-LEDs on F. nucleatum was examined.…”

Section: Introductionmentioning

confidence: 87%

Deep Ultraviolet Light-Emitting Diode Light Therapy for Fusobacterium nucleatum

et al. 2021

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Background: Fusobacterium nucleatum, which is associated with periodontitis and gingivitis, has been detected in colorectal cancer (CRC). Methods: We evaluated the bactericidal effect of deep ultraviolet (DUV) light-emitting diode (LED) light therapy on F. nucleatum both qualitatively and quantitatively. Two DUV-LEDs with peak wavelengths of 265 and 280-nm were used. DNA damage to F. nucleatum was evaluated by the production of cyclobutane pyrimidine dimers (CPD) and pyrimidine (6–4) pyrimidone photoproducts (6–4PP). Results: DUV-LEDs showed a bactericidal effect on F. nucleatum. No colony growth was observed after 3 min of either 265 nm or 280 nm DUV-LED irradiation. The survival rates of F. nucleatum under 265 nm DUV-LED light irradiation dropped to 0.0014% for 10 s and to 0% for 20 s irradiation. Similarly, the survival rate of F. nucleatum under 280 nm DUV-LED light irradiation dropped to 0.00044% for 10 s and 0% for 20 s irradiation. The irradiance at the distance of 35 mm from the DUV-LED was 0.265 mW/cm2 for the 265 nm LED and 0.415 mW/cm2 for the 280 nm LED. Thus, the radiant energy for lethality was 5.3 mJ/cm2 for the 265 nm LED and 8.3 mJ/cm2 for the 280 nm LED. Amounts of CPD and 6–4PP in F. nucleatum irradiated with 265 nm DUV-LED light were 6.548 ng/µg and 1.333 ng/µg, respectively. Conclusions: DUV-LED light exerted a bactericidal effect on F. nucleatum by causing the formation of pyrimidine dimers indicative of DNA damage. Thus, DUV-LED light therapy may have the potential to prevent CRC.

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Oxidative stress-induced DNA damage and DNA repair mechanisms in mangrove bacteria exposed to climatic and heavy metal stressors

Rath,

Das

2023

Environmental Pollution

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Microbicidal effect of deep ultraviolet light-emitting diode irradiation

Cited by 4 publications

References 12 publications

UV C Light from a Light-Emitting Diode at 275 Nanometers Shortens Wound Healing Time in Bacterium- and Fungus-Infected Skin in Mice

UV C Light from a Light-Emitting Diode at 275 Nanometers Shortens Wound Healing Time in Bacterium- and Fungus-Infected Skin in Mice

Deep Ultraviolet Light-Emitting Diode Light Therapy for Fusobacterium nucleatum

Oxidative stress-induced DNA damage and DNA repair mechanisms in mangrove bacteria exposed to climatic and heavy metal stressors

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