2018
DOI: 10.1007/s10620-018-5369-9
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Microbiome: An Emerging New Frontier in Graft-Versus-Host Disease

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Cited by 21 publications
(26 citation statements)
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“…The copyright holder for this preprint this version posted February 8, 2021. ; https://doi.org/10.1101/2021.02.04.21251019 doi: medRxiv preprint correlate with lower abundance of regulatory T cells 46 and impaired T-cell mediated local immune suppression 31 . Moreover, the loss of commensal bacteria that produce indole-3-aldehyde (including Clostridia class members), a metabolite that modulates barrier integrity by stimulating intestinal stem cell growth, is also linked to aGVHD development 47 .…”
Section: (Which Was Not Certified By Peer Review)mentioning
confidence: 99%
See 1 more Smart Citation
“…The copyright holder for this preprint this version posted February 8, 2021. ; https://doi.org/10.1101/2021.02.04.21251019 doi: medRxiv preprint correlate with lower abundance of regulatory T cells 46 and impaired T-cell mediated local immune suppression 31 . Moreover, the loss of commensal bacteria that produce indole-3-aldehyde (including Clostridia class members), a metabolite that modulates barrier integrity by stimulating intestinal stem cell growth, is also linked to aGVHD development 47 .…”
Section: (Which Was Not Certified By Peer Review)mentioning
confidence: 99%
“…Indeed, oral bacteria translocation to the gut has been described in allo-HSCT recipients, and the presence of oral Actinobacteria and oral Firmicutes in stool samples of these patients was positively correlated with subsequent aGVHD development 7 . Alternatively, DBM enterococci may have an intestinal origin, since the injury to Goblet cells during conditioning regimen was shown to induce dissemination of dominant intestinal bacteria 31 . Further studies evaluating synchronously IM and DBM are necessary to decipher whether IM and DBM enterococci bloom are linked and which event precedes the other.…”
mentioning
confidence: 99%
“…85 The nature of the bacterial, viral, and/or fungal species, and molecules involved in these spectra of effects, remains to be elucidated, and it is now important to understand both pathogenic and protective components of the microbiome and delineate true cause-and-effect relationships with GVHD. 86,87 Of note, IECs in the ileum can constitutively express MHC-II in mice and humans, 38,88 presumably depending on the nature of commensal microbiota. Likewise, the nature of costimulatory signals delivered by nonhematopoietic APCs or the neighboring cells that are required to stimulate donor T cells within tissue remains to be elucidated.…”
Section: Effects Of the Microbiome On Alloantigen Presentationmentioning
confidence: 99%
“…1,3,6 Understanding the importance of the gastrointestinal microflora in the course of GvHD may contribute to the development of new therapeutic strategies. 7,8 In recent years, attempts have been made to transplant intestinal microflora from healthy donors as a treatment for intestinal GvHD. Therefore, this study presented two cases of patients undergoing allo-HSCT who were selected for fecal microbiota transplantation (FMT).…”
Section: Introductionmentioning
confidence: 99%