Microbiome dysbiosis in cancer: Exploring therapeutic strategies to counter the disease

Sharma, Var Ruchi; Singh, Manoj; Kumar, Vikas; Yadav, Mukesh; Sehrawat, Nirmala; Sharma, Daljit K.; Sharma, Anil Kumar

doi:10.1016/j.semcancer.2020.07.006

Cited by 32 publications

(23 citation statements)

References 138 publications

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“…In recent years, researchers have focused in assessing the role of microbes in carcinogenesis (Eslami et al, 2020;Sharma et al, 2021). In the year 2018, there were more than 17 million new cases of human cancer, making cancer as one of the main causes of death worldwide (Ferlay et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Periodontitis as a Risk Factor for Breast Cancer – What We Know Till Date?

Issrani

Reddy²,

Prabhu

2021

Asian Pac J Cancer Prev

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Section: Introductionmentioning

confidence: 99%

Periodontitis as a Risk Factor for Breast Cancer – What We Know Till Date?

Issrani

Reddy²,

Prabhu

2021

Asian Pac J Cancer Prev

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“…In summary, it is evident that P. gingivalis harnesses and responds to the entire complement of in-host substrates and metabolites to modulate lifestyle, virulence, and its interaction with the existing microbiota and host cells. The data provide further support for studying dysbiosis in the oral microbiome, which is considered as an important risk factor for the onset of chronic inflammation and a variety of systemic diseases 83 – 85 .…”

Section: Discussionmentioning

confidence: 60%

Metabolic plasticity enables lifestyle transitions of Porphyromonas gingivalis

Moradali

Davey

2021

npj Biofilms Microbiomes

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Our understanding of how the oral anaerobe Porphyromonas gingivalis can persist below the gum line, induce ecological changes, and promote polymicrobial infections remains limited. P. gingivalis has long been described as a highly proteolytic and asaccharolytic pathogen that utilizes protein substrates as the main source for energy production and proliferation. Here, we report that P. gingivalis displays a metabolic plasticity that enables the exploitation of non-proteinaceous substrates, specifically the monocarboxylates pyruvate and lactate, as well as human serum components, for colonization and biofilm formation. We show that anabolism of carbohydrates from pyruvate is powered by catabolism of amino acids. Concomitantly, the expression of fimbrial adhesion is upregulated, leading to the enhancement of biofilm formation, stimulation of multispecies biofilm development, and increase of colonization and invasion of the primary gingival epithelial cells by P. gingivalis. These studies provide the first glimpse into the metabolic plasticity of P. gingivalis and its adaptation to the nutritional condition of the host niche. Our findings support the model that in response to specific nutritional parameters, P. gingivalis has the potential to promote host colonization and development of a pathogenic community.

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“…The complex and bidirectional relationship between gut microbiota and carcinogenesis has received considerable attention in recent years. Intestinal microbes and cancer cells co-evolve in the body's ecosystem, and they may compete with each other for incoming resources necessary to survival and replication 100 . Daily diet, energy or nutrients may influence the growth of both microbial cells and cancer cells.…”

Section: Gut Microbiota and Urogenital System Tumormentioning

confidence: 99%

The Effects and Mechanisms of Flavonoids on Cancer Prevention and Therapy: Focus on Gut Microbiota

Wang¹,

Yu²,

Zhang³

et al. 2022

Int. J. Biol. Sci.

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Flavonoids are a group of polyphenolic compounds which are ubiquitously found in plants and are consumed as part of the human diet in substantial amounts. The verification of flavonoids' cancer chemopreventive benefits has led to a significant interest in this field. Gut microbiota includes a diverse community of microorganisms and has a close relationship with cancer development. Increasing evidence has indicated that flavonoids exert anticarcinogenic effects by reshaping gut microbiota. Gut microbiota can convert flavonoids into bioactive metabolites that possess anticancer activity. Here, we present a brief introduction to gut microbiota and provide an overview of the interplay between gut microbiota and cancer pathogenesis. We also highlight the crucial roles of flavonoids in preventing cancer based on their regulation of gut microbiota. This review would encourage research on the flavonoid-intestinal microbiota interactions and clinical trials to validate the chemotherapeutic potentials of targeting gut microbiota by dietary bioactive compounds.

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Microbiome dysbiosis in cancer: Exploring therapeutic strategies to counter the disease

Cited by 32 publications

References 138 publications

Periodontitis as a Risk Factor for Breast Cancer – What We Know Till Date?

Periodontitis as a Risk Factor for Breast Cancer – What We Know Till Date?

Metabolic plasticity enables lifestyle transitions of Porphyromonas gingivalis

The Effects and Mechanisms of Flavonoids on Cancer Prevention and Therapy: Focus on Gut Microbiota

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