Microbiota composition in bilateral healthy breast tissue and breast tumors

Klann, Emily; Williamson, Jessica M.; Tagliamonte, Massimiliano S.; Ukhanova, Maria; Asirvatham, Jaya Ruth; Chim, Harvey; Yaghjyan, Lusine; Mai, Volker

doi:10.1007/s10552-020-01338-5

Cited by 32 publications

(46 citation statements)

References 48 publications

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“…Some of our taxonomic findings were similarly noted in previous 16S rRNA studies in the United States 15 ; however, of note, it is possible taxa‐disease associations may differ by geographic location 32 . Intriguingly, some gut taxa associated with breast disease in our study were previously present at higher abundances in breast tumor tissue compared to normal tissue (eg, taxa in family Prevotellaceae and family Ruminococcaceae) 33,34 …”

Section: Discussionsupporting

confidence: 85%

“…32 Intriguingly, some gut taxa associated with breast disease in our study were previously present at higher abundances in breast tumor tissue compared to normal tissue (eg, taxa in family Prevotellaceae and family Ruminococcaceae). 33,34 It is plausible that bacteria may be involved in breast disease through multiple pathways including those related and unrelated to hormonal regulation. Taxa with estrogen-deconjugating enzymatic activity, characterized by the presence of genes for β-glucuronidase or β-galactosidase, 7 are hypothesized to have enzymatic activities that promote reabsorption of unconjugated estrogens into circulation, contributing to estrogenic burden.…”

Section: Resultsmentioning

confidence: 99%

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Associations of fecal microbial profiles with breast cancer and nonmalignant breast disease in the Ghana Breast Health Study

Byrd

Vogtmann

et al. 2021

Intl Journal of Cancer

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The gut microbiota may play a role in breast cancer etiology by regulating hormonal, metabolic and immunologic pathways. We investigated associations of fecal bacteria with breast cancer and nonmalignant breast disease in a case‐control study conducted in Ghana, a country with rising breast cancer incidence and mortality. To do this, we sequenced the V4 region of the 16S rRNA gene to characterize bacteria in fecal samples collected at the time of breast biopsy (N = 379 breast cancer cases, N = 102 nonmalignant breast disease cases, N = 414 population‐based controls). We estimated associations of alpha diversity (observed amplicon sequence variants [ASVs], Shannon index, and Faith's phylogenetic diversity), beta diversity (Bray‐Curtis and unweighted/weighted UniFrac distance), and the presence and relative abundance of select taxa with breast cancer and nonmalignant breast disease using multivariable unconditional polytomous logistic regression. All alpha diversity metrics were strongly, inversely associated with odds of breast cancer and for those in the highest relative to lowest tertile of observed ASVs, the odds ratio (95% confidence interval) was 0.21 (0.13‐0.36; Ptrend < .001). Alpha diversity associations were similar for nonmalignant breast disease and breast cancer grade/molecular subtype. All beta diversity distance matrices and multiple taxa with possible estrogen‐conjugating and immune‐related functions were strongly associated with breast cancer (all Ps < .001). There were no statistically significant differences between breast cancer and nonmalignant breast disease cases in any microbiota metric. In conclusion, fecal bacterial characteristics were strongly and similarly associated with breast cancer and nonmalignant breast disease. Our findings provide novel insight into potential microbially‐mediated mechanisms of breast disease.

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Section: Discussionsupporting

confidence: 85%

Section: Resultsmentioning

confidence: 99%

Associations of fecal microbial profiles with breast cancer and nonmalignant breast disease in the Ghana Breast Health Study

Byrd

Vogtmann

et al. 2021

Intl Journal of Cancer

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“…Alternatively, a notable decrease in symbiotic microbes like Prevotella , Lactococcus , and Sphingomonas have been associated with BD [ 9 , 22 , 25 , 27 , 28 ]. A possible explanation pertains to the interaction between the microorganisms and activation of natural killer cells to inhibit tumour growth [ 27 ].…”

Section: Resultsmentioning

confidence: 99%

“…A study conducted by Urbaniak et al., provides greater insight into the role of skin bacteria in BC. Staphylococcus , a common skin commensal, was among the most abundant genera identified in BC tissue [ 24 , 27 , 28 ] and has further been implicated in BC metastasis [ 30 ]. Further characterisation of the species within the Staphylococcus genus is needed to understand which are involved in the breast oncogenic process.…”

Section: Resultsmentioning

confidence: 99%

Is the skin microbiota a modifiable risk factor for breast disease?: A systematic review

et al. 2021

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…In addition, the bacteria associated with breast cancer shared b-glucuronidase activity and, therefore, the authors suggested that this enzymatic activity may promote breast cancer. Recently, two studies described racial differences in the microbiome of breast tumors (Smith et al, 2019;Thyagarajan et al, 2020) while another study identified differences in diversity and composition not only between tumor and normal tissue but also among women and between the breasts of the same woman (Klann et al, 2020).…”

Section: Microbiota Of the Breast Tissue Of Non-lactating Womenmentioning

confidence: 99%

The Microbiota of the Human Mammary Ecosystem

Fernández

Pannaraj

Rautava

et al. 2020

Front. Cell. Infect. Microbiol.

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Human milk contains a dynamic and complex site-specific microbiome, which is not assembled in an aleatory way, formed by organized microbial consortia and networks. Presence of some genera, such as Staphylococcus, Streptococcus, Corynebacterium, Cutibacterium (formerly known as Propionibacterium), Lactobacillus, Lactococcus and Bifidobacterium, has been detected by both culture-dependent and culture-independent approaches. DNA from some gut-associated strict anaerobes has also been repeatedly found and some studies have revealed the presence of cells and/or nucleic acids from viruses, archaea, fungi and protozoa in human milk. Colostrum and milk microbes are transmitted to the infant and, therefore, they are among the first colonizers of the human gut. Still, the significance of human milk microbes in infant gut colonization remains an open question. Clinical studies trying to elucidate the question are confounded by the profound impact of non-microbial human milk components to intestinal microecology. Modifications in the microbiota of human milk may have biological consequences for infant colonization, metabolism, immune and neuroendocrine development, and for mammary health. However, the factors driving differences in the composition of the human milk microbiome remain poorly known. In addition to colostrum and milk, breast tissue in lactating and non-lactating women may also contain a microbiota, with implications in the pathogenesis of breast cancer and in some of the adverse outcomes associated with breast implants. This and other open issues, such as the origin of the human milk microbiome, and the current limitations and future prospects are addressed in this review.

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Microbiota composition in bilateral healthy breast tissue and breast tumors

Cited by 32 publications

References 48 publications

Associations of fecal microbial profiles with breast cancer and nonmalignant breast disease in the Ghana Breast Health Study

Associations of fecal microbial profiles with breast cancer and nonmalignant breast disease in the Ghana Breast Health Study

Is the skin microbiota a modifiable risk factor for breast disease?: A systematic review

The Microbiota of the Human Mammary Ecosystem

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