Microbiota modulation and effects on metabolic biomarkers by orange juice: a controlled clinical trial

Fidélix, Melaine; Milenković, Dragan; Sivieri, Kátia; César, Thaís Borges

doi:10.1039/c9fo02623a

Cited by 55 publications

(49 citation statements)

References 43 publications

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“…To the best of our knowledge, this is the first study to assess insulin sensitivity in subjects consuming OJ utilizing an OGTT-derived index. Our results are in contrast to those of previous studies that reported improved insulin sensitivity in subjects consuming OJ when assessed by HOMA-IR [25,54,55]. It is possible that the improved [55] or unaffected [25] HOMA-IR observed in subjects consuming OJ in previous studies may relate to the amount of OJ consumed.…”

Section: Discussioncontrasting

confidence: 99%

“…Our results are in contrast to those of previous studies that reported improved insulin sensitivity in subjects consuming OJ when assessed by HOMA-IR [25,54,55]. It is possible that the improved [55] or unaffected [25] HOMA-IR observed in subjects consuming OJ in previous studies may relate to the amount of OJ consumed. The subjects in our study consumed more than twice the amount of OJ as the subjects in these studies [25,55].…”

Section: Discussioncontrasting

confidence: 99%

“…It is possible that the improved [55] or unaffected [25] HOMA-IR observed in subjects consuming OJ in previous studies may relate to the amount of OJ consumed. The subjects in our study consumed more than twice the amount of OJ as the subjects in these studies [25,55]. However, we [59], and others [60] have previously suggested that HOMA-IR is a less reliable index of insulin sensitivity than the indices generated during hyperinsulinemia euglycemic clamps, OGTT or fast sample intravenous glucose tolerance tests.…”

Section: Discussionmentioning

confidence: 96%

“…We did not observe a significant increase in these risk factors in the subjects consuming OJ. Previous studies showed that consuming OJ at 7% [54,55] or 10% [56] of calories resulted in a lowering of both total cholesterol and LDL in healthy participants. In another study, decreases of LDL were observed in 14 hypercholesteremic subjects consuming 10% of energy as OJ for 8 weeks, but not in 31 normocholesterolemic subjects [57].…”

Section: Discussionmentioning

confidence: 98%

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A Pilot Study Comparing the Effects of Consuming 100% Orange Juice or Sucrose-Sweetened Beverage on Risk Factors for Cardiometabolic Disease in Women

et al. 2021

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Overconsumption of sugar-sweetened beverages increases risk factors associated with cardiometabolic disease, in part due to hepatic fructose overload. However, it is not clear whether consumption of beverages containing fructose as naturally occurring sugar produces equivalent metabolic dysregulation as beverages containing added sugars. We compared the effects of consuming naturally-sweetened orange juice (OJ) or sucrose-sweetened beverages (sucrose-SB) for two weeks on risk factors for cardiometabolic disease. Healthy, overweight women (n = 20) were assigned to consume either 3 servings of 100% orange juice or sucrose-SB/day. We conducted 16-hour serial blood collections and 3-h oral glucose tolerance tests during a 30-h inpatient visit at baseline and after the 2-week diet intervention. The 16-h area under the curve (AUC) for uric acid increased in subjects consuming sucrose-SB compared with subjects consuming OJ. Unlike sucrose-SB, OJ did not significantly increase fasting or postprandial lipoproteins. Consumption of both beverages resulted in reductions in the Matsuda insulin sensitivity index (OJ: −0.40 ± 0.18, p = 0.04 within group; sucrose-SB: −1.0 ± 0.38, p = 0.006 within group; p = 0.53 between groups). Findings from this pilot study suggest that consumption of OJ at levels above the current dietary guidelines for sugar intake does not increase plasma uric acid concentrations compared with sucrose-SB, but appears to lead to comparable decreases of insulin sensitivity.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 98%

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A Pilot Study Comparing the Effects of Consuming 100% Orange Juice or Sucrose-Sweetened Beverage on Risk Factors for Cardiometabolic Disease in Women

et al. 2021

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“…and Ruminococcus spp. according to other authors [168], suggesting that orange juice showed a prebiotic effect, modulating the intestinal microbiota by improving blood sugar and the lipid profile. In a recent review [169], it was highlighted how the beneficial effects of hesperidin on cardiovascular risk factors can be partly attributed to the modulation of the intestinal microbiota.…”

Section: Comorbiditiesmentioning

confidence: 59%

Reappraisal of Dietary Phytochemicals for Coronavirus Infection: Focus on Hesperidin and Quercetin

Bellavite¹

2021

Antioxidants - Benefits, Sources, Mechanisms of Action

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Food polyphenols constitute a large family of substances with beneficial properties in a large group of communicable and non-communicable diseases. These compounds support and improve the body’s defences against oxidative stress and are helpful in the prevention of pathologies related to metabolic syndrome. Furthermore, they exhibit anti-inflammatory, antiviral, and antimicrobial properties. This chapter draws attention to certain nutritional components such as hesperidin and quercetin, which are emerging as good candidates for a complementary beneficial effect in the case of diseases caused by viruses, including COVID-19. These nutraceuticals have a complex mechanism of action, which involves both cellular defence against oxidative stress and the modulation of inflammation, which although normally is a defence, repair and activation mechanism of the immune system, it can elude its controls and become a systemic and destructive pathology (cytokine storm, respiratory distress syndrome). Furthermore, recent in silico simulation tests suggest that both hesperidin and quercetin may interfere with SARS-CoV-2 by binding to cell receptors and the proteolytic enzymes involved in its replication. In addition to the inhibitory effects on the virus at cellular level, the two flavonoids can have indirect effects in respiratory infectious diseases as they prevent or improve metabolic and vascular comorbidities that can complicate the clinical course. This brief review focuses on biochemical and pharmacological mechanisms of action of polyphenols in the context of the revaluation of dietary approaches to the prevention and treatment of infectious diseases caused by viruses, with a special application to COVID-19.

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Therapeutic potential of dietary nutrients and medicinal foods against metabolic disorders: Targeting Akkermansia muciniphila

Xu,

Zhang,

Yang

et al. 2024

Food Frontiers

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As one of the most attractive next‐generation probiotics, mucin‐degrading Akkermansia muciniphila has emerged as an essential and integral factor in maintaining human health and affecting pathological outcomes. Its abundance is inversely associated with various metabolic diseases (e.g., obesity and type 2 diabetes), cardiovascular diseases, and intestinal inflammation. Supplementing A. muciniphila to restore the gut microbiota ecosystem is a promising approach for treating metabolic disorders. However, the direct utilization of this probiotic is limited by technological and regulatory hurdles, such as the in vitro bulk culture of A. muciniphila and the need for expensive animal‐derived materials. Therefore, enrichment of A. muciniphila using nutraceutical supplements is a feasible strategy. Dietary supplements, especially medicinal herbs, offer a vast and valuable resource as potential prebiotics for promoting the growth of A. muciniphila in the gut, ensuring reliable safety and efficacy. In this study, we first systemically reviewed the dietary substances and medicinal foods known to promote A. muciniphila from over 100 literature sources, aiming to establish a candidate basis for future exploration of prebiotics targeting A. muciniphila. Furthermore, we summarized and discussed the major regulatory factors and mechanisms responsible for the beneficial effect of A. muciniphila on metabolic disorders, hoping to open up exciting directions for in‐depth research on the pharmacological mechanism of A. muciniphila and pave the way for its clinical therapeutics.

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Microbiota modulation and effects on metabolic biomarkers by orange juice: a controlled clinical trial

Abstract: Regular consumption of 300 ml of orange juice d−1 for 60 days altered the intestinal microbiota, increasing Akkermansia and Lactobacillus, while Ruminococcus decreased. These changes were inversely correlated with metabolic biomarkers in women.

Cited by 55 publications

References 43 publications

A Pilot Study Comparing the Effects of Consuming 100% Orange Juice or Sucrose-Sweetened Beverage on Risk Factors for Cardiometabolic Disease in Women

A Pilot Study Comparing the Effects of Consuming 100% Orange Juice or Sucrose-Sweetened Beverage on Risk Factors for Cardiometabolic Disease in Women

Reappraisal of Dietary Phytochemicals for Coronavirus Infection: Focus on Hesperidin and Quercetin

Therapeutic potential of dietary nutrients and medicinal foods against metabolic disorders: Targeting Akkermansia muciniphila

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