Microcirculatory Bed, Microcirculation, and Smoking-Associated Endothelial Dysfunction in Young Adults

Korneeva, N. V.; Сиротин, Б. З.

doi:10.1007/s10517-017-3722-1

Cited by 6 publications

(4 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Central obesity as well as smoking may induce relative increase in BP in SCD patients through direct effect on the kidneys and/or insulin resistance-induced activation of the sympathetic nervous system and renin angiotensin aldosterone system [14] [29] [30]. Microalbuminuria in SCD could be both a cause and a consequence of high blood pressure.…”

Section: Discussionmentioning

confidence: 99%

Blood Pressure Patterns and Factors Associated with Relative Hypertension among Steady State Sickle Cell Disease Patients in Kinshasa, Democratic Republic of the Congo: A Cross-Sectional Study

Mboliasa¹,

Lepira²,

Makulo³

et al. 2018

WJCD

View full text Add to dashboard Cite

Background: Although systemic hypertension is rarely seen in steady state sickle cell disease (SCD), relative hypertension has been reported to be associated with an increased risk of cardiovascular and renal complications. Objective: To determine the prevalence of BP patterns and assess factors associated with relative hypertension in sickle cell anemia (SCA) adult patients. Methods: Clinical data and office BP were obtained from 103 consecutive steady-state SCA adult patients (mean age 26 ± 7.9 years, 66% females, 22.3% on hydroxyurea) attending four healthcare centers providing SCD-specific care in Kinshasa. Seated BP was measured using an automated electronic device. Three consecutive blood pressure measurements were taken with 2 minutes interval between readings and the average of the 2 last readings was considered for the analyses. Normal BP, relative hypertension and systemic hypertension were defined as BP < 120/70 mmHg, 120 -139/70 -89 mmHg and ≥140/90 mmHg, respectively. Results: Normal BP, relative hypertension and systemic hypertension were observed in 56 (54%), 43 (42%) and 4 (4%) of SCA patients, respectively. In multivariate analysis, factors associated with relative hypertension were leg ulcer (aOR 2.05; 95%CI 1.77 -5.18; p = 0.016), central obesity (aOR 3.32; 95%CI 1.28 -6.24; p = 0.001), smoking (aOR 5.02; 95%CI 1.51 -9.50; p = 0.017), and microalbumiuria (aOR 3.44; 95%CI 1.44 -5.76; p = 0.035). Conclusion: Relative hypertension was a common finding in the present case series and associated with traditional cardiovascular risk factor as well as factors specific to SCD highlighting the need for measures to prevent its progression towards systemic hypertension and associated cardiovascular and renal disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Blood Pressure Patterns and Factors Associated with Relative Hypertension among Steady State Sickle Cell Disease Patients in Kinshasa, Democratic Republic of the Congo: A Cross-Sectional Study

Mboliasa¹,

Lepira²,

Makulo³

et al. 2018

WJCD

View full text Add to dashboard Cite

show abstract

“…Finally, the outflow of the aqueous humor through the trabeculectomy and filtering bleb requires a functional vessel network to be drained into the systemic circulation. Previous researchers indicated that tobacco smoking alters the microcirculation of the conjunctiva, causing endothelial dysfunction (28) as well as affecting the episcleral venous pressure increase due to vasoconstriction (13,14) . Another factor in the failure of these cases might be the restriction of the outflow of aqueous humor beyond the trabeculectomy site.…”

Section: Figurementioning

confidence: 99%

Effect of tobacco smoking on outcomes of trabeculectomy

Acosta¹,

Gould²,

Rahman³

et al. 2022

ABO

View full text Add to dashboard Cite

To evaluate the effect of tobacco smoking on trabeculectomy outcomes. Methods: Charts of patients with glaucoma who underwent trabeculectomy performed by a single surgeon between 2007 and 2016 were retrospectively reviewed. Charts were screened for a documented history of smoking status before surgery. Demographic and clinical preoperative variables were recorded. Based on smoking history, subjects were divided into two groups: smokers and nonsmokers. Any bleb-related interventions (e.g., 5-flourouracil injections ± laser suture lysis) or bleb revision performed during the postoperative period were noted. Success was defined as an intraocular pressure >5 mmHg and <21 mm Hg without (complete success) or with (qualified success) the use of ocular hypotensive medications. Failure was identified as a violation of the criteria mentioned above. Results: A total of 98 eyes from 83 subjects were included. The mean age of the subjects was 70.7 ± 11.09 years, and 53% (44/83) were female. The most common diagnosis was primary open-angle glaucoma in 47 cases (47.9%). The smokers Group included 30 eyes from 30 subjects. When compared with nonsmokers, smokers had a significantly worse preoperative best-corrected visual acuity (p=0.038), greater central corneal thickness (p=0.047), and higher preoperative intraocular pressure (p=0.011). The success rate of trabeculectomy surgery at 1 year was 56.7% in the smokers Group compared with 79.4% in the Group nonsmokers (p=0.020). Smoking presented an odds ratio for failure of 2.95 (95% confidence interval, 1.6-7.84). Conclusion: Smokers demonstrated a significantly lower success rate 1 year after trabeculectomy compared with nonsmokers and a higher requirement for bleb-related interventions.

show abstract

“…Finally, endothelial dysfunction - often defined as impaired NO bioavailability - acts as a common player in most cardiovascular (CV) risk factors ( Rajendran et al, 2013 ), underlining the importance of endothelial NO signaling in CV ageing and disease. Such risk factors include hypertension ( Panza et al, 1990 ; Perticone et al, 2001 ), arterial stiffness ( Leloup et al, 2019 ), smoking ( Korneeva and Sirotin, 2017 ), diabetes ( Calver et al, 1992 ), obesity ( Engin, 2017 ), inflammation ( Yang et al, 2016 ), and oxidative stress ( Cai and Harrison, 2000 ).…”

Section: Introductionmentioning

confidence: 99%

Basal Vascular Smooth Muscle Cell Tone in eNOS Knockout Mice Can Be Reversed by Cyclic Stretch and Is Independent of Age

et al. 2022

View full text Add to dashboard Cite

Introduction and Aims: Endothelial nitric oxide synthase (eNOS) knockout mice develop pronounced cardiovascular disease. In the present study, we describe the alterations in aortic physiology and biomechanics of eNOS knockout and C57Bl/6 control mice at 2–12 months of age, including a thorough physiological investigation of age and cyclic stretch-dependent VSMC contractility and aortic stiffness.Methods and Results: Peripheral blood pressure and aortic pulse wave velocity were measured in vivo, and aortic biomechanical studies and isometric contractions were investigated ex vivo. Age-dependent progression of aortic stiffness, peripheral hypertension, and aortic contractility in eNOS knockout mice was absent, attenuated, or similar to C57Bl/6 control mice. Voltage-gated calcium channel (VGCC)-dependent calcium influx inversely affected isometric contraction and aortic stiffening by α1-adrenergic stimulation in eNOS knockout mice. Baseline aortic stiffness was selectively reduced in eNOS knockout mice after ex vivo cyclic stretch exposure in an amplitude-dependent manner, which prompted us to investigate cyclic stretch dependent regulation of aortic contractility and stiffness. Aortic stiffness, both in baseline conditions and after activation of vascular smooth muscle cell (VSMC) contraction, was reduced with increasing cyclic stretch amplitude. This cyclic stretch dependency was attenuated with age, although aged eNOS knockout mice displayed better preservation of cyclic stretch-dependency compared to C57Bl/6 control mice. Store operated calcium entry-medicated aortic stiffening as induced by inhibiting sarcoplasmic reticulum calcium ATPase pumps with 10 µM CPA was most pronounced in the aorta of aged mice and at low cyclic stretch amplitude, but independent of eNOS. Basal aortic tonus and VSMC depolarization were highly dependent on eNOS, and were most pronounced at low cyclic stretch, with attenuation at increasing cyclic stretch amplitude.Conclusion: eNOS knockout mice display attenuated progression of arterial disease as compared to C57Bl/6 control mice. Basal VSMC tone in eNOS knockout mice could be reduced by ex vivo exposure to cyclic stretch through stretch-dependent regulation of cytosolic calcium. Both baseline and active aortic stiffness were highly dependent on cyclic stretch regulation, which was more pronounced in young versus aged mice. Other mediators of VSMC contraction and calcium handling were dependent on cyclic stretch mechanotransduction, but independent of eNOS.

show abstract

Microcirculatory Bed, Microcirculation, and Smoking-Associated Endothelial Dysfunction in Young Adults

Cited by 6 publications

References 10 publications

Blood Pressure Patterns and Factors Associated with Relative Hypertension among Steady State Sickle Cell Disease Patients in Kinshasa, Democratic Republic of the Congo: A Cross-Sectional Study

Blood Pressure Patterns and Factors Associated with Relative Hypertension among Steady State Sickle Cell Disease Patients in Kinshasa, Democratic Republic of the Congo: A Cross-Sectional Study

Effect of tobacco smoking on outcomes of trabeculectomy

Basal Vascular Smooth Muscle Cell Tone in eNOS Knockout Mice Can Be Reversed by Cyclic Stretch and Is Independent of Age

Contact Info

Product

Resources

About