2019
DOI: 10.1016/j.bone.2019.03.011
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Microcracks in subchondral bone plate is linked to less cartilage damage

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Cited by 24 publications
(28 citation statements)
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“…It was hypothesized that microcracks initiated OA by targeted remodeling, featured by the repair of microcracks in the CCZ ( Goldring, 2009 ). More recently, microcracks have been reported to have a negative correlation with the progression of OA, indicating that microcracks are a necessity in the homeostasis of the cartilage-bone unit ( Zarka et al, 2019 ). Based on previous findings, some researchers attribute the microcracks as the canals for osteoclast-chondrocyte crosstalk, the regulation of chondrocytes by osteoclast in the subchondral bone promotes the loss of cartilage integrity and OA progression ( Hu et al, 2020 ).…”
Section: Structural and Functional Properties Of The Subchondral Bone Platementioning
confidence: 99%
“…It was hypothesized that microcracks initiated OA by targeted remodeling, featured by the repair of microcracks in the CCZ ( Goldring, 2009 ). More recently, microcracks have been reported to have a negative correlation with the progression of OA, indicating that microcracks are a necessity in the homeostasis of the cartilage-bone unit ( Zarka et al, 2019 ). Based on previous findings, some researchers attribute the microcracks as the canals for osteoclast-chondrocyte crosstalk, the regulation of chondrocytes by osteoclast in the subchondral bone promotes the loss of cartilage integrity and OA progression ( Hu et al, 2020 ).…”
Section: Structural and Functional Properties Of The Subchondral Bone Platementioning
confidence: 99%
“…In the early stages of OA, an increased rate of bone remodeling leads to a thinner subchondral bone plate and decreased bone volume in trabecular bone. Increased bone remodeling may be associated with the accumulation of microcracks [ 32 ]. However, in end stage OA, fewer microcracks have been reported, which can be explained by thicker trabeculae and the strengthened architecture of the subchondral trabecular bone [ 33 ].…”
Section: Impact Of Obesity On Joint Pathologymentioning
confidence: 99%
“…In fact, they also have been widely investigated as an endogenous seed cell type in the past three decades [79,80]. Selfrepair of the partial-and full-thickness cartilage defects is rare or even considered to be absent, which might be greatly attributed to the dense subchondral bone plate (SBP) between the cartilage and bone marrow cavity [81,82]. Although SBP is a thin tissue, it can effectively block BMSCs from migrating into cartilage tissue.…”
Section: Bmscsmentioning
confidence: 99%