Microcystic Macular Edema

Abegg, Mathias; Dysli, Muriel; Wolf, Sebastian; Kowal, Jens; Dufour, Pascal; Zinkernagel, Martin S.

doi:10.1016/j.ophtha.2013.08.045

Cited by 126 publications

(72 citation statements)

References 21 publications

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“…This is in contrast to the study of Abegg et al ,13 where they found that younger patients had a significantly higher chance of having microcystic changes then older patients. In our view, it is difficult to attribute this to age alone and future prospective studies addressing this question will need to be careful to avoid an inclusion bias due to the age distribution of various aetiologies.…”

Section: Discussioncontrasting

confidence: 99%

“…It has also been suggested that retrograde axonal degeneration influences the integrity of the retinal organisation and that loss of retinal Müller cell function may play a role in microcyst formation 4 8 10 13 14. Finally, vitreoretinal traction can lead to the formation of microcystic changes,5 7 but does not represent an unifying mechanism because it has conclusively shown to be absent in a number of cases 25.…”

Section: Discussionmentioning

confidence: 99%

“…This has since been confirmed and scanning laser ophthalmoscopy (SLO) was added to the list more recently 8 10 12 13. Taken together these imaging modalities consistently describe the microcysts to be distributed in a circular area or semicircular area around the fovea 8 10–13 16.…”

Section: Introductionmentioning

confidence: 91%

“…As the aetiology of this retinal abnormality remains unknown and the evidence for oedema not conclusively been provided, Kisimbi et al 11 suggested to be careful about the terminology. Therefore, Abegg et al 13 proposed to refer to a ‘retrograde maculopathy’.…”

Section: Introductionmentioning

confidence: 99%

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The prevalence of microcystic macular changes on optical coherence tomography of the macular region in optic nerve atrophy of non-neuritis origin: a prospective study

2015

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

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The prevalence of microcystic macular changes on optical coherence tomography of the macular region in optic nerve atrophy of non-neuritis origin: a prospective study

2015

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“…Image analysis was done as described previously, using a custom-built segmentation software [1, 10]. This resulted in a single thickness value per retinal layer.…”

Section: Methodsmentioning

confidence: 99%

Acetazolamide Reduces Retinal Inner Nuclear Layer Thickness in Microcystic Macular Edema Secondary to Optic Neuropathy

et al. 2018

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Optic neuropathy (ON) is commonly complicated by microcystic macular edema (MME), that is, small vertical cystoid spaces in the inner nuclear layer (INL) of the macula. We performed a retrospective consecutive case series of 14 eyes from 11 patients with ON and MME that were treated with oral acetazolamide, acting on cellular water transport. Contralateral eyes without MME were used as controls. Segmentation of images obtained with OCT was used to determine changes of individual retinal layer thickness during treatment. Retinal INL thickness consistently decreased in all eyes after 2–3 weeks of treatment. Recurrence of MME was observed after treatment cessation. No significant change of retinal thickness was found in contralateral unaffected eyes. Visual function did not change with treatment. Acetazolamide significantly improved the MME in eyes with ON. However, visual function did not. Acetazolamide is a treatment option for MME associated with ON but without an impact on the visual function.

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Artificial intelligence extension of the OSCAR‐IB criteria

Petzold

Albrecht

Balcer

et al. 2021

Ann Clin Transl Neurol

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Artificial intelligence (AI)-based diagnostic algorithms have achieved ambitious aims through automated image pattern recognition. For neurological disorders, this includes neurodegeneration and inflammation. Scalable imaging technology for big data in neurology is optical coherence tomography (OCT). We highlight that OCT changes observed in the retina, as a window to the brain, are small, requiring rigorous quality control pipelines. There are existing tools for this purpose. Firstly, there are human-led validated consensus quality control criteria (OSCAR-IB) for OCT. Secondly, these criteria are embedded into OCT reporting guidelines (APOSTEL). The use of the described annotation of failed OCT scans advances machine learning. This is illustrated through the present review of the advantages and disadvantages of AI-based applications to OCT data. The neurological conditions reviewed here for the use of big data include Alzheimer disease, stroke, multiple sclerosis (MS), Parkinson disease, and epilepsy. It is noted that while big data is relevant for AI, ownership is complex. For this reason, we also reached out to involve representatives from patient organizations and the public domain in addition to clinical and research centers. The evidence reviewed can be grouped in a five-point expansion of the OSCAR-IB criteria to embrace AI (OSCAR-AI). The review concludes by specific recommendations on how this can be achieved practically and in compliance with existing guidelines.

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Microcystic Macular Edema

Cited by 126 publications

References 21 publications

The prevalence of microcystic macular changes on optical coherence tomography of the macular region in optic nerve atrophy of non-neuritis origin: a prospective study

The prevalence of microcystic macular changes on optical coherence tomography of the macular region in optic nerve atrophy of non-neuritis origin: a prospective study

Acetazolamide Reduces Retinal Inner Nuclear Layer Thickness in Microcystic Macular Edema Secondary to Optic Neuropathy

Artificial intelligence extension of the OSCAR‐IB criteria

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